DEVELOPING A MODEL OF STRESS-INDUCED OBESITY

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 这项研究的目的是开发程序，以更好地了解舒适食物摄入的神经机制。 摄入高热量的舒适食品以缓解社会环境压力导致肥胖流行的观点正在得到认可。 猴子是社会性圈养的，那些处于从属社会地位的猴子表现出行为和内分泌压力指数。 雌猴的手腕皮下植入了一个电脑芯片，当它把手伸进自动喂食器时，就会识别出猴子，并提供一粒食物。 通过这种方式，每周7天，每天24小时监测食物摄入量。 在该项目的最后一年，我们发现，当在典型的低脂肪，高纤维猴子饮食（LCD）和高脂肪和糖饮食（HCD）之间进行选择时，占主导地位的女性更喜欢HCD，但也继续吃LCD。 从属动物也更喜欢HCD，但在选择条件下消耗的卡路里几乎是主导动物的两倍。 当选择被删除，下属继续来显着更多的热量的不太喜欢的液晶显示器。 行为研究表明，在删除HCD数据后，焦虑样行为显著增加。 最后，HCD的消耗实际上增加而不是减少应激激素的反应。 这些研究为社会环境变量如何导致人类过度食物消费和肥胖提供了见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This study is designed to develop procedures to better understand the neural mechanisms for the ingestion of comfort foods. The notion that the ingestion of calorically dense comfort foods to relieve socio-environmental stressors contributes to the obesity epidemic is gaining acceptance. Monkeys are housed socially and those of subordinate social status show behavioral and endocrine indices of stress. Females had a computer chip implanted subcutaneously in the wrist that, when reaching into an automated feeding dispenser would identify the monkey and deliver one pellet of food. In this way, food intake was monitored 24 hours per day, seven days a week. In the final year of the project, we showed that when given a choice between the typical low fat, high fiber monkey diet (LCD) and a diet high in fat and sugar (HCD), dominant females prefer the HCD but continue to eat the LCD as well. Subordinates too preferred the HCD but consumed nearly twice as many calories during the choice condition as did the dominant animals. When the choice was removed, subordinates continued to come significantly more calories of the less preferred LCD. Behavioral studies indicated that upon the removal of the HCD data, anxiety-like behavior increased significantly. Finally, consumption of the HCD actually increases rather decreases stress hormone responsiveness. These studies are providing insights into how socio-environmental variable may contribute to excess food consumption and obesity in humans.