DEVELOPING A MODEL OF STRESS-INDUCED OBESITY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项研究旨在开发程序，以更好地了解摄入舒适食物的神经机制。摄入高热量的舒适食品以缓解社会环境压力是肥胖流行的原因，这一观点正在被人们接受。 猴子在社会上被安置，而那些处于从属社会地位的猴子会显示出压力的行为和内分泌指数。雌性猴子的手腕皮下植入了一个计算机芯片，当伸手进入自动喂食器时，它会识别猴子的身份，并分发一粒食物。通过这种方式，一周七天、每天24小时监测食物摄入量。 在该项目的最后一年，我们发现，在典型的低脂肪、高纤维猴子饮食(LCD)和高脂肪高糖饮食(HCD)之间进行选择时，占主导地位的雌性更喜欢HCD，但也会继续吃LCD。从属动物也喜欢HCD，但在选择条件下消耗的卡路里几乎是优势动物的两倍。当选择被移除时，下属继续摄入较不受欢迎的LCD的明显更多的卡路里。行为研究表明，删除HCD数据后，焦虑样行为显著增加。 最后，HCD的摄入实际上增加而不是降低了应激激素的反应性。这些研究正在为社会环境变量如何导致人类过度食物消费和肥胖提供洞察力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This study is designed to develop procedures to better understand the neural mechanisms for the ingestion of comfort foods. The notion that the ingestion of calorically dense comfort foods to relieve socio-environmental stressors contributes to the obesity epidemic is gaining acceptance. Monkeys are housed socially and those of subordinate social status show behavioral and endocrine indices of stress. Females had a computer chip implanted subcutaneously in the wrist that, when reaching into an automated feeding dispenser would identify the monkey and deliver one pellet of food. In this way, food intake was monitored 24 hours per day, seven days a week. In the final year of the project, we showed that when given a choice between the typical low fat, high fiber monkey diet (LCD) and a diet high in fat and sugar (HCD), dominant females prefer the HCD but continue to eat the LCD as well. Subordinates too preferred the HCD but consumed nearly twice as many calories during the choice condition as did the dominant animals. When the choice was removed, subordinates continued to come significantly more calories of the less preferred LCD. Behavioral studies indicated that upon the removal of the HCD data, anxiety-like behavior increased significantly. Finally, consumption of the HCD actually increases rather decreases stress hormone responsiveness. These studies are providing insights into how socio-environmental variable may contribute to excess food consumption and obesity in humans.