NEUROENDOCRINE MEDIATION OF SOCIALLY INDUCED ANOVULATION

社会诱发的无排卵的神经内分泌调节

• 批准号: 8357427
• 负责人: Mark E Wilson
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357427
• 关键词: Adult; Alleles; Animals; Anovulation; Behavioral; Brain region; Data; Diet; Eating; Energy Metabolism; Estradiol; Fatty acid glycerol esters; Feedback; Female; Fiber; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Housing; Individual; Infertility; Intake; Length; Macaca mulatta; Measures; Mediation; Metabolic; Monkeys; National Center for Research Resources; Neurosecretory Systems; Outcome; Positron-Emission Tomography; Primates; Principal Investigator; Psychosocial Stress; Research; Research Infrastructure; Resources; Serotonin; Source; Stress; Testing; United States National Institutes of Health; Variant; Woman; adverse outcome; cost; experience; insight; neuroimaging; promoter; receptor; reproductive; reuptake; social; treatment strategy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Studies were completed assessing the consequences of psychosocial stress, resulting from social subordination, on metabolic, reproductive, and behavioral outcomes in adult female rhesus monkeys. In addition, the contribution of polymorphisms in the gene that encodes the serotonin reuptake transporter (5HTT) was evaluated as studies show individuals with one or both alleles of the short promoter length variant (s-variant) are more vulnerable to the adverse consequences of psychosocial stress than those homozygous for the long promoter length (l/l). During the final year, studies show that the reproductive compromise experienced by subordinate females is due to enhanced estradiol negative feedback inhibition of LH secretion but that this can be alleviated by access to a high caloric diet. Other studies use PET neuroimaging tested the hypotheses that GABAergic receptor subtype A would be diminished in subordinate s-variant females in brain regions associated with stress reactivity. All PET scans were completed in October 2010 and analyses are underway. Additional studies used automated feeders to quantify intake of standard low fat, high fiber monkey chow in socially housed females to better understand the metabolic deficits observed in subordinates. Activity levels, as a surrogate measure of energy expenditure were measured as well. Data indicate that subordinates, regardless of genotype, eat less of this diet than dominant animals but show similar amounts of activity. These studies provide insights into possible treatment strategies for women suffering from stress-induced infertility.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 研究完成了评估的后果，心理社会压力，导致社会从属地位，代谢，生殖和行为的结果在成年雌性恒河猴。 此外，评价了编码5-羟色胺再摄取转运蛋白（5 HTT）的基因多态性的贡献，因为研究表明，具有短启动子长度变体（s-变体）的一个或两个等位基因的个体比长启动子长度（l/l）纯合子的个体更容易受到心理社会压力的不良后果的影响。 在最后一年，研究表明，生殖妥协所经历的下属女性是由于增强雌二醇的LH分泌的负反馈抑制，但这可以减轻获得高热量的饮食。 其他研究使用PET神经成像测试假设，GABA能受体亚型A将减少在从属S-变异女性与应激反应相关的大脑区域。 所有PET扫描均于2010年10月完成，分析正在进行中。 另外的研究使用自动喂食器来量化社会圈养雌性中标准低脂肪、高纤维猴子食物的摄入量，以更好地了解在下属中观察到的代谢缺陷。 还测量了活动水平，作为能量消耗的替代测量。 数据表明，下属，无论基因型，吃这种饮食比占主导地位的动物少，但表现出类似的活动量。这些研究为患有压力诱发的不孕症的妇女提供了可能的治疗策略。