EFFECTIVE DETECTION OF PCOS IN OLD WORLD MONKEYS

有效检测旧世界猴子中的多囊卵巢综合症

• 批准号: 8357533
• 负责人: Mark E Wilson
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357533
• 关键词: Adult; Biological Assay; Cardiovascular Diseases; Cercopithecidae; Child; Clinical; Detection; Disease; Endometrial Carcinoma; Etiology; Female; Funding; Grant; Human; Infertility; Intervention; Macaca mulatta; Metabolic Diseases; Modeling; National Center for Research Resources; Nature; Non-Insulin-Dependent Diabetes Mellitus; Phenotype; Pilot Projects; Polycystic Ovary Syndrome; Population; Primates; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Risk; Sampling; Services; Shipping; Ships; Source; Syndrome; United States National Institutes of Health; Wisconsin; Woman; cost; falls; lifetime risk; nonhuman primate; novel; prevent; reproductive; sample collection; stem

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is a translational multi-center project to initiate novel studies into the pathophysiological origins of a highly prevalent reproductive and metabolic disorder in women, namely polycystic ovary syndrome (PCOS). This hyperandrogenic syndrome increases a woman's lifetime risk of type 2 diabetes, cardiovascular disease, endometrial cancer and infertility. Our focus on PCOS stems from the highly pervasive, but heterogeneous nature of the disease, and our incomplete understanding of its etiology in women. We now need a naturally-occurring phenotype in a nonhuman primate model as well as an ability to target children at risk of PCOS to develop novel clinical interventions to prevent or diminish the adult PCOS phenotype. In this pilot project begun in late Fall 2009, we are establishing the efficacy of both nonhuman primate and human approaches with a consortium of multiple Primate Centers and the Wisconsin CTSA. The PI is David Abbott at the WNPRC. Our targeted use of appropriate nonhuman primate populations and expertise at three Primate Centers minimizes redundancies in resources available nationally and our utilization of Assay Services within the WCTSA demonstrates our sharing of a single core resource. The Yerkes investigators have completed sample collection on 150 adult female rhesus monkeys. All samples have been shipped to Dr Abbott at the WNPRC for analysis.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这是一个转化多中心项目，旨在启动对女性中高度流行的生殖和代谢疾病（即多囊卵巢综合征（PCOS））的病理生理起源的新研究。这种高雄激素综合征会增加女性一生中患2型糖尿病、心血管疾病、子宫内膜癌和不孕症的风险。 我们对PCOS的关注源于这种疾病的高度普遍性，但异质性，以及我们对其女性病因的不完全理解。我们现在需要在非人灵长类动物模型中自然发生的表型，以及针对有PCOS风险的儿童的能力，以开发新的临床干预措施来预防或减少成人PCOS表型。在2009年秋末开始的这个试点项目中，我们正在与多个灵长类中心和威斯康星州CTSA的联盟建立非人灵长类动物和人类方法的有效性。 PI是WNPRC的大卫雅培。 我们在三个灵长类动物中心有针对性地使用适当的非人灵长类动物种群和专业知识，最大限度地减少了全国可用资源的冗余，我们在WCTSA内使用分析服务，表明我们共享单一核心资源。 耶基斯的研究人员已经完成了对150只成年雌性恒河猴的样本采集。 所有样本均已运送至WNPRC的Abbott博士处进行分析。