GESTATIONAL DIABETES IN RHESUS MONKEYS

恒河猴的妊娠期糖尿病

• 批准号: 8357503
• 负责人: Mark E Wilson
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357503
• 关键词: American; Cell Nucleus; Clinical Research; Cohort Studies; Data; Development; Diabetes Mellitus; Experimental Animal Model; Female; Foundations; Funding; Gestational Diabetes; Glucose; Grant; Health; Human; Hyperglycemia; Incidence; Insulin Resistance; Macaca mulatta; Modeling; Monkeys; National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Pilot Projects; Population; Pregnancy; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Risk; Serum; Source; United States National Institutes of Health; blood glucose regulation; cardiovascular disorder risk; cost; glucose tolerance; offspring; pregnant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Gestational diabetes mellitus (GDM) is an increasingly prevalent problem with important health and societal impact, yet controversies continue in the most elementary issues related to GDM. While clinical studies are assessing the effects of maternal hyperglycemia on subsequent development of obesity, insulin resistance, diabetes, and cardiovascular disease risk in the offspring, progress is hampered by the absence of a good experimental animal model. While clinicians report that frank gestational diabetes is rare in the monkey population at Yerkes, they are presented with only the most advanced cases. No systematic studies of glucose tolerance have been done in the captive population. During the year, we initiated a pilot project to identify pregnant female rhesus monkeys at risk for gestational diabetes. Of 10 females studied during pregnancy, three have serum glucose in excess of 160 mg/dl, clearly indicative of potential problems with glucose regulation. Data are being collected on a large number of rhesus females to better understand the incidence in our population The data generated in these studies will serve as the nucleus for grants submitted to the NIH (e.g. NICHD, NIDDK, NHLBI) and foundations, such as the American Diabetes Association and March of Dimes. The rhesus monkey model blends well with our concurrent study of human gestational diabetes and a two-species approach will provide a unique edge in national competitions.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 妊娠期糖尿病（GDM）是一个日益普遍的问题，具有重要的健康和社会影响，但仍有争议的最基本的问题，与GDM。 虽然临床研究正在评估母体高血糖对后代肥胖、胰岛素抵抗、糖尿病和心血管疾病风险的后续发展的影响，但由于缺乏良好的实验动物模型，进展受到阻碍。虽然临床医生报告说，坦率的妊娠糖尿病是罕见的猴子人口在耶基斯，他们提出的只有最先进的情况。 在圈养种群中没有进行系统的葡萄糖耐量研究。 年内，我们开展了一项试验计划，以识别有患妊娠期糖尿病风险的妊娠雌性恒河猴。 在妊娠期间研究的10名女性中，3名的血清葡萄糖超过160 mg/dl，这清楚地表明葡萄糖调节存在潜在问题。 正在收集大量雌性恒河猴的数据，以更好地了解我们人群的发病率。这些研究产生的数据将作为提交给NIH（例如NICHD，NIDDK，NHLBI）和基金会（如美国糖尿病协会和March of Dimes）的赠款的核心。 恒河猴模型与我们同时进行的人类妊娠期糖尿病研究很好地融合在一起，两种方法将在国家比赛中提供独特的优势。