GESTATIONAL DIABETES IN RHESUS MONKEYS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 妊娠期糖尿病(GDM)是一个日益普遍的问题，具有重要的健康和社会影响，但在与GDM相关的最基本问题上仍存在争议。虽然临床研究正在评估母亲高血糖对后代肥胖、胰岛素抵抗、糖尿病和心血管疾病风险的影响，但由于缺乏良好的实验动物模型，进展受到阻碍。虽然临床医生报告说，坦率的妊娠期糖尿病在耶尔克斯的猴子群体中很少见，但他们只看到了最晚期的病例。目前还没有关于圈养种群葡萄糖耐量的系统研究。 年内，我们启动了一项试点项目，以确定怀孕的雌性恒河猴有患妊娠期糖尿病的风险。在怀孕期间研究的10名女性中，有3名的血糖水平超过160毫克/分升，这清楚地表明了血糖调节方面的潜在问题。目前正在收集大量雌性恒河猴的数据，以更好地了解我们人群中的发病率。这些研究产生的数据将作为向NIH(如NICHD、NIDDK、NHLBI)和基金会(如美国糖尿病协会和DIMES三月)提交的拨款的核心。恒河猴模型与我们同时进行的人类妊娠期糖尿病研究很好地融合在一起，两个物种的方法将在国家竞争中提供独特的优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Gestational diabetes mellitus (GDM) is an increasingly prevalent problem with important health and societal impact, yet controversies continue in the most elementary issues related to GDM. While clinical studies are assessing the effects of maternal hyperglycemia on subsequent development of obesity, insulin resistance, diabetes, and cardiovascular disease risk in the offspring, progress is hampered by the absence of a good experimental animal model. While clinicians report that frank gestational diabetes is rare in the monkey population at Yerkes, they are presented with only the most advanced cases. No systematic studies of glucose tolerance have been done in the captive population. During the year, we initiated a pilot project to identify pregnant female rhesus monkeys at risk for gestational diabetes. Of 10 females studied during pregnancy, three have serum glucose in excess of 160 mg/dl, clearly indicative of potential problems with glucose regulation. Data are being collected on a large number of rhesus females to better understand the incidence in our population The data generated in these studies will serve as the nucleus for grants submitted to the NIH (e.g. NICHD, NIDDK, NHLBI) and foundations, such as the American Diabetes Association and March of Dimes. The rhesus monkey model blends well with our concurrent study of human gestational diabetes and a two-species approach will provide a unique edge in national competitions.