Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

• 批准号: 8101216
• 负责人: JANE M CARLTON
• 金额: $ 149.96万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8101216
• 关键词: Center; Study; Complex; Malaria; India

DESCRIPTION (provided by applicant): In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. The National Institute of Malaria Research (NIMR) in New Delhi is the only institute in India dedicated to finding short- and long-term solutions to the problem of malaria through basic, applied, and operational field research. The Center for the Study of Complex Malaria in India (CSCMi) will bring together a group of leading US experts in the fields of malaria parasite research to work in tandem with faculty at the NIMR. Malaria in India is 'complex'; two predominant species of parasite infect almost equal numbers of people, and may be present serially or concurrently in one person. Each species also has multiple strains (genotypes) that can serially or concurrently infect. Indian malaria complexity, its variation by location, and its consequences for malaria severity and transmission, are the research focus of the CSCMi, which aims to develop the knowledge, tools, and evidence-based strategies needed to support the intervention and control programs of Indian government organizations, and to build research capacity in India and help train its next generation of malaria and mosquito vector biologists. CSCMi research comprises three Projects: 1) Epidemiology, 2) Transmission, and 3) Pathology and Diagnosis. Project 1 will rely on multiple blood samples from 3000 (1000 x 3) longitudinally-tracked individuals, both symptomatic and asymptomatic for different malarias, recruited at three ecologically and epidemiologically diverse NIMR field sites. It will assess how infection complexity, parasite diversity, and transmission rate impact immunity. Project 2 will investigate ecological and evolutionary determinants of malaria transmission, and the efficacy of novel evolution-proof bio-insecticides for disrupting transmission of simple and complex malaria. Project 3 will deploy next-generation genomics to study multiplicity of infection and the rise of antimalarial drug-resistant clones, and to develop a diagnostic test for drug-resistant parasites. CSCMi projects will be supported by Administrative, Data Management, and Genomics Cores to be located at the NIMR's new facility in Dwarka, New Delhi.

描述（由申请人提供）：在印度，世界上最大的民主国家和人口第二多的国家，疟疾仍然是一个巨大的公共卫生问题。位于新德里的国家疟疾研究所（NIMR）是印度唯一一个致力于通过基础、应用和业务实地研究寻找疟疾问题短期和长期解决方案的研究所。印度复杂疟疾研究中心（CSCMi）将汇集一批美国疟疾寄生虫研究领域的领先专家，与NIMR的教师合作。印度的疟疾是“复杂的”;两种主要的寄生虫感染几乎相同数量的人，并且可能连续或同时出现在一个人身上。每个物种也有多个菌株（基因型），可以连续或同时感染。印度疟疾的复杂性，其因地点而异，以及其对疟疾严重程度和传播的影响，是CSCMi的研究重点，其目的是开发支持印度政府组织的干预和控制计划所需的知识，工具和循证策略，并建立印度的研究能力，并帮助培训下一代疟疾和蚊媒生物学家。CSCMi研究包括三个项目：1）流行病学，2）传播，3）病理学和诊断。项目1将依赖于来自3000（1000 x 3）个经循证追踪的个体的多个血液样本，这些个体包括不同疟疾的症状性和无症状性个体，这些个体是在三个生态学和流行病学上不同的NIMR现场招募的。它将评估感染复杂性、寄生虫多样性和传播率如何影响免疫力。项目2将调查疟疾传播的生态和进化决定因素，以及新型抗进化生物杀虫剂在阻断简单和复杂疟疾传播方面的功效。项目3将部署下一代基因组学，研究感染的多重性和抗疟药物耐药性克隆的增加，并开发耐药性寄生虫的诊断测试。CSCMi项目将得到位于新德里Dwarka的NIMR新设施的行政、数据管理和基因组核心的支持。