Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

• 批准号: 10599992
• 负责人: JANE M CARLTON
• 金额: $ 32.37万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10599992
• 关键词: Address; Anti-malarial drug resistance; Biology; Blood Volume; Blood specimen; Clinic; Cohort Studies; Complex; Country; Detection; Development; Genes; Genome; Genomics; Haplotypes; India; Individual; Infection; Knowledge; Malaria; Maps; Measures; Methods; Parasites; Patients; Plasmodium vivax; Population; Relapse; Research; Site; Technology; Time; biomarker identification; detection method; genetic signature; genome sequencing; genomic platform; improved; nanopore; primary outcome; recurrent infection; relapse patients; screening; serological marker; tool; whole genome

PROJECT 2 SUMMARY In this project, we address key gaps in our knowledge of P. vivax hypnozoite biology through screening relapse patients for serological markers associated with the carriage of hypnozoites. We also plan to develop the Oxford Nanopore Technologies MinION genomics platform for use at our field sites in India. Finally, we will continue our development of a P. vivax haplotype map to identify India-specific selective sweeps and hot- spots, and sequence the genomes of P. vivax parasites from relapse patients. Our focus on P. vivax biology in this project is concordant with the recent announcement of an Indian National Framework for Malaria Elimination, which outlines a “Special strategy for P. vivax elimination” since “more than 80% of the global P. vivax burden is contributed by 3 countries including India”.

项目2概要 在这个项目中，我们通过筛查复发来解决我们对间日疟原虫催眠子生物学知识的关键空白 患者的血清学标志物与携带催眠虫。我们亦计划发展 Oxford Nanopore Technologies MinION基因组学平台用于我们在印度的现场。最后我们将 继续开发间日疟原虫单倍型图谱，以确定印度特异性选择性扫描和热- 斑点，并对复发患者的间日疟原虫寄生虫的基因组进行测序。我们对间日疟原虫生物学的关注 该项目与最近宣布的印度国家疟疾框架相一致 消除，其中概述了“消除间日疟原虫的特殊策略”，因为“全球80%以上的间日疟原虫都是在全球范围内消灭的。 间日疟负担由包括印度在内的3个国家造成”。