Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

• 批准号: 10394160
• 负责人: JANE M CARLTON
• 金额: $ 105.55万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394160
• 关键词: Adult; Age; Antibodies; Antiparasitic Agents; Area; Binding; Biological; Biological Markers; Biology; Biostatistics Core; Brain; Brain Edema; Brain Pathology; CD4 Positive T Lymphocytes; Censuses; Cerebral Malaria; Cerebrum; Childhood; Clinic; Clinical; Cohort Studies; Complex; Country; Cross-Sectional Studies; Data; Democracy; Detection; Development; Diagnosis; Disease; Effectiveness; Epidemiology; Genetic; Genomics; Genotype; Geography; Goals; Human; Hypoxia; Imaging Techniques; Immune; Immune response; Immunity; Incidence; India; Individual; Infection; Integration Host Factors; Intervention; Knowledge; Link; Location; Magnetic Resonance; Magnetic Resonance Imaging; Malaria; Malawi; Methods; MicroRNAs; Molecular; Morbidity - disease rate; Natural Selections; Organ; Outcome; Parasites; Pathogenesis; Pathology; Patients; Pattern Recognition; Perfusion; Persons; Phenotype; Plasmodium; Plasmodium vivax; Population; Process; Public Health; Relapse; Research; Research Institute; Research Project Grants; Retina; Retinal Diseases; Role; Sampling; Serology; Severities; Signal Transduction; Site; Spectrum Analysis; Surveys; Symptoms; Time; Tissues; Variant; activated protein C receptor; age related; base; biomarker identification; cohort; comparative; data management; density; differential expression; disease transmission; effectiveness evaluation; evidence base; genetic signature; high risk; improved; insight; international center; malaria infection; male; mortality; outcome prediction; primary outcome; programs; regional difference; serological marker; tool; vector mosquito

OVERALL SUMMARY In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. Malaria in India is 'complex'; two predominant species of parasite may be present serially or concurrently in one person. Each species also has multiple strains (genotypes) that can serially or concurrently infect. Indian malaria complexity, its variation by location, and its consequences for malaria immunity and severity, are the research focus of the CSCMi. The aims of the Center are to develop the knowledge, tools, and evidence-based strategies needed to support Indian intervention and control programs, and to build research capacity in India. CSCMi research comprises three projects: Project 1: Epidemiology of malaria and infection dynamics, Project 2: P. vivax diagnosis, genomics and biology, and Project 3: Pathogenesis of cerebral malaria. Project 1 will undertake census, cross-sectional surveys, survey-cohorts, and clinic-based cohort studies for malaria baseline epidemiology and identification of asymptomatic n=and relapse individuals at our three ecologically and epidemiologically diverse field sites in Sundergarh District, Odisha, West Garo Hills in Meghalaya, and Jaintia Hills in Meghalaya. It will use biological samples collected during these studies to assess how infection complexity impacts seroepidemiology and CD4+ immune signatures in asymptomatic versus clinical malaria. Project 2 will investigate biomarkers of P. vivax hypnozoite infection, and deploy real-time genomics methods of diagnosis and for population genomics. Project 3 will use magnetic resonance imaging techniques to study cerebral malaria pathogenesis in an unprecedented and comprehensive comparative analysis between patients in India and Malawi, and investigate molecular pathogenetic mechanisms of disease. The CSCMi projects will be supported by an Administrative Core and Data Management and Biostatistics Core, and advised by a team of consultants and a Scientific Advisory Group.

总体汇总 在印度这个世界上最大的民主国家和人口第二多的国家，疟疾仍然是一个巨大的威胁。 公共卫生问题。印度的疟疾是“复杂的”;可能存在两种主要的寄生虫 连续地或同时地在一个人身上。每个物种也有多个菌株（基因型），可以连续或 同时感染。印度疟疾的复杂性，其位置的变化及其对疟疾的影响 免疫性和严重性是CSCMi的研究重点。该中心的目标是发展 支持印度干预和控制项目所需的知识、工具和循证战略， 并在印度建立研究能力。CSCMi研究包括三个项目：项目1： 疟疾和感染动力学，项目2：间日疟原虫诊断、基因组学和生物学，项目3： 脑型疟疾的发病机制。项目1将进行人口普查、跨部门调查、同期调查， 疟疾基线流行病学和确定无症状疟疾病例的基于临床的队列研究 我们在Sundergarh区的三个生态和流行病学多样化的实地调查点， 奥里萨邦、梅加拉亚的西加罗山和梅加拉亚的杰恩蒂亚山。它将使用收集到的生物样本 在这些研究中，评估感染复杂性如何影响血清流行病学和CD 4+免疫 无症状疟疾与临床疟疾的特征。项目2将研究间日疟原虫催眠子的生物标志物 感染，并部署实时基因组学诊断方法和人口基因组学。项目3将使用 磁共振成像技术，研究脑疟疾发病机制，在一个前所未有的， 印度和马拉维患者之间的全面比较分析，并研究分子 疾病的发病机制。CSCMi项目将得到行政核心的支持， 数据管理和生物统计学核心，并由顾问团队和科学顾问提供咨询 组