CDP-Choline and Working Memory after Traumatic Brain Injury: A Neuroimaging Study

CDP-胆碱与脑外伤后的工作记忆：一项神经影像学研究

• 批准号: 8119702
• 负责人: PATRICIA M ARENTH
• 金额: $ 10.2万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119702
• 关键词: Aftercare; Area; Behavioral; Cerebrum; Cognition; Cognitive; Cognitive Therapy; Consensus; Control Groups; Cytidine Diphosphate Choline; Data; Effectiveness; Emotional; Functional Magnetic Resonance Imaging; Goals; Human; Image; Imaging Techniques; Individual; Intervention; Measures; Memory; Memory impairment; Methods; Neurobiology; Neuropsychological Tests; Patients; Pattern; Performance; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Placebo Control; Placebos; Positron-Emission Tomography; Pre-Post Tests; Prefrontal Cortex; Prevalence; Problem Solving; Process; Rehabilitation Research; Rehabilitation therapy; Research; Research Personnel; Research Priority; Sampling Studies; Short-Term Memory; Test Result; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; base; career development; cognitive function; comparison group; disability; functional disability; functional outcomes; hemodynamics; improved; indexing; information processing; neuroimaging; neurophysiology; neuropsychological; performance tests; programs; relating to nervous system; response; treatment effect

DESCRIPTION (provided by the applicant): Despite the prevalence of working memory deficits following traumatic brain injury (TBI), the scientific data regarding pharmacological treatment of this problem is limited. As deficits in working memory are known to have a significant impact on functional outcomes for individuals with TBI, further research in this area is essential. The primary goal of the proposed project is to examine the efficacy of CDP Choline in the treatment of working memory deficits following TBI. The study sample will consist of 48 subjects including a group of 24 individuals who have sustained moderate to severe TBI and a group of 24 healthy controls. Each group will be divided into a placebo and treatment group. The project will utilize functional Magnetic Resonance Imaging (fMRI) to investigate the cerebral neurophysiological effects of treatment with the drug of choice. A working memory task will be employed during the fMRI sessions. The effects of treatment with CDP Choline will be evaluated on neuropsychological testing performance also and correlations between behavioral performance and neuroimaging results will be observed. Results will be compared pre and post test or one month after treatment. The study postulates the following assumptions: 1) Baseline fMRI results will show altered patterns of cerebral activation for persons with TBI compared to normals; 2)With treatment, TBI subjects will display fMRI patterns that more resemble healthy controls; 3) Improvements in behavioral performance on both neuropsychological tests and the working memory task will be associated with treatment, with greater changes in the TBI group comparisons.; 4) correlations between neuropsychological tests and neuroimaging results will be stronger for persons with TBI as compared to placebo/control groups.

描述（由申请人提供）：尽管创伤性脑损伤（TBI）后工作记忆缺陷普遍存在，但有关该问题药物治疗的科学数据仍然有限。由于已知工作记忆缺陷会对 TBI 患者的功能结果产生重大影响，因此该领域的进一步研究至关重要。该项目的主要目标是检查 CDP 胆碱治疗 TBI 后工作记忆缺陷的功效。研究样本将由 48 名受试者组成，其中包括 24 名患有中度至重度 TBI 的个体和 24 名健康对照者。每组将分为安慰剂组和治疗组。该项目将利用功能磁共振成像（fMRI）来研究所选药物治疗对脑神经生理学的影响。在功能磁共振成像会议期间将采用工作记忆任务。 CDP 胆碱治疗的效果还将根据神经心理学测试表现进行评估，并观察行为表现和神经影像结果之间的相关性。将在测试前和测试后或治疗后一个月对结果进行比较。该研究假设以下假设：1）基线功能磁共振成像结果将显示，与正常人相比，TBI 患者的大脑激活模式发生了改变； 2）通过治疗，TBI受试者将表现出更类似于健康对照的fMRI模式； 3) 神经心理学测试和工作记忆任务的行为表现的改善将与治疗相关，TBI 组比较的变化更大； 4) 与安慰剂/对照组相比，TBI 患者的神经心理学测试和神经影像学结果之间的相关性更强。