Genomics

基因组学共享资源（GSR）是一个最先进的基因组学设施，致力于提供 最新的低成本基因组研究工具。GSR的主要目标是促进高影响力 斯坦福大学癌症中心成员的基因组癌症研究。这一目标是通过以下方式实现的 为癌症中心成员提供尖端技术和服务， 专业知识和利用这些基因组工具所需的科学支持。技术和服务 目前由GSR提供的包括：高通量测序（Illumina Genome Analyzer II，ABI SOLID、Roche Genome Sequencer FLX和Helicos HeliScope），微阵列服务利用 Affytechnic、Agilent、Illumina、Nimblegen、斯坦福大学和其他平台，基因分型服务利用 Affytek和Illumina平台，实时定量PCR。基因组试剂，如克隆， 微阵列和加标对照。专家协助使用这些 技术也贯穿于整个实验过程。实验指导 设计、数据分析、数据存档和出版是GSR的主要组成部分。的资源 斯坦福大学功能基因组学研究中心（SFGF）、蛋白质和核酸研究中心（PAN），以及 斯坦福大学微阵列数据库（SMD）已经结合起来，提供全方位的服务， Genomics共享资源，总运营预算为280万美元。John Coiler，博士 （SFGF），是共享资源的主任，凯瑟琳球，博士（SMD）和迈克尔埃卡特，博士 (PAN)共同指挥枪击残留物帕特里克布朗，医学博士，博士和加文夏洛克，博士是教师顾问。那里 目前有96名癌症中心成员使用共享资源，代表所有项目附属机构。 未来的目标是增加高通量测序技术的使用， 实施最新一代基因组学工具所需的生物信息学支持和基础设施。

The Genomics Shared Resource (GSR) is a state-of-the-art genomics facility dedicated to providing the latest genomic research tools at low-cost. The primary goal of the GSR is to facilitate high-impact genomic-based cancer research by Stanford Cancer Center members. This goal is accomplished by providing Cancer Center members with access to cutting-edge technologies and providing the services, expertise, and scientific support necessary for utilizing these genomic tools. Technologies and services currently provided by the GSR include: high-throughput sequencing (Illumina Genome Analyzer II, ABI SOLID, Roche Genome Sequencer FLX, and Helicos HeliScope), microarray services utilizing Affymetrix, Agilent, Illumina, Nimblegen, Stanford, and other platforms, genotyping services utilizing the Affymetrix and Illumina platforms, real-time quantitative PCR. Genomic reagents, such as clones, microarrays, and spike-in controls are also provided. Expert assistance with the use of these technologies is also provided throughout the entire experimental process. Guidance with experimental design, data analysis, data archiving and publication is a major component of the GSR. The resources of the Stanford Functional Genomics Facility (SFGF), Protein and Nucleic Acid Facility (PAN), and Stanford Microarray Database (SMD) have combined to provide the full spectrum of services offered by the Genomics Shared Resource and has a total combined operating budget of $2.8M. John Coiler, PhD (SFGF), is the Director of the shared resource, and Catherine Ball, PhD (SMD) and Michael Eckart, PhD (PAN) co-direct the GSR. Patrick Brown, MD, PhD and Gavin Sherlock, PhD are faculty advisors. There are currently 96 Cancer Center members using the shared resource, representing all program affiliations. Future goals are to increase access to high-throughput sequencing technologies and improve bioinformatics support and infrastructure required to implement the latest generation of genomics tools.