Genomics

基因组学共享资源(GSR)是一种最先进的基因组学设施，致力于提供 最新的基因组研究工具，价格低廉。GSR的主要目标是促进高影响力 斯坦福癌症中心成员的基于基因组的癌症研究。这一目标通过以下方式实现 为癌症中心成员提供接触尖端技术和提供服务的机会， 利用这些基因组工具所需的专业知识和科学支持。技术和服务 目前由GSR提供的包括：高通量测序(Illumina Genome Analyzer II，ABI Solid、Roche Genome Sequencer Flx和Helicos HeliScope)、微阵列服务利用 Affymetrix、Agilent、Illumina、NimbleGen、Stanford等平台，利用基因分型服务 Affymetrix和Illumina平台，实时定量PCR。基因组试剂，如克隆， 还提供了微阵列和尖峰控制。通过使用这些工具提供专家帮助 在整个实验过程中还提供了技术。以实验为指导 设计、数据分析、数据存档和出版是GSR的一个主要组成部分。的资源 斯坦福大学功能基因组学设施(SFGF)、蛋白质和核酸设施(PAN)以及 斯坦福微阵列数据库(SMD)已联合起来，提供由 基因组学共享资源，总运营预算为280万美元。约翰·科勒，博士 (SFGF)，是共享资源的主任，凯瑟琳·鲍尔博士(SMD)和迈克尔·埃卡尔博士 (PAN)共同指导GSR。帕特里克·布朗，医学博士和加文·夏洛克博士是教职员工顾问。那里 目前有96名癌症中心成员使用共享资源，代表所有项目附属机构。 未来的目标是增加获得高通量测序技术的机会，并改进 实施最新一代基因组学工具所需的生物信息学支持和基础设施。

The Genomics Shared Resource (GSR) is a state-of-the-art genomics facility dedicated to providing the latest genomic research tools at low-cost. The primary goal of the GSR is to facilitate high-impact genomic-based cancer research by Stanford Cancer Center members. This goal is accomplished by providing Cancer Center members with access to cutting-edge technologies and providing the services, expertise, and scientific support necessary for utilizing these genomic tools. Technologies and services currently provided by the GSR include: high-throughput sequencing (Illumina Genome Analyzer II, ABI SOLID, Roche Genome Sequencer FLX, and Helicos HeliScope), microarray services utilizing Affymetrix, Agilent, Illumina, Nimblegen, Stanford, and other platforms, genotyping services utilizing the Affymetrix and Illumina platforms, real-time quantitative PCR. Genomic reagents, such as clones, microarrays, and spike-in controls are also provided. Expert assistance with the use of these technologies is also provided throughout the entire experimental process. Guidance with experimental design, data analysis, data archiving and publication is a major component of the GSR. The resources of the Stanford Functional Genomics Facility (SFGF), Protein and Nucleic Acid Facility (PAN), and Stanford Microarray Database (SMD) have combined to provide the full spectrum of services offered by the Genomics Shared Resource and has a total combined operating budget of $2.8M. John Coiler, PhD (SFGF), is the Director of the shared resource, and Catherine Ball, PhD (SMD) and Michael Eckart, PhD (PAN) co-direct the GSR. Patrick Brown, MD, PhD and Gavin Sherlock, PhD are faculty advisors. There are currently 96 Cancer Center members using the shared resource, representing all program affiliations. Future goals are to increase access to high-throughput sequencing technologies and improve bioinformatics support and infrastructure required to implement the latest generation of genomics tools.