Comparative Biogerontology Core

比较生物老年学核心

• 批准号: 8122848
• 负责人: RICHARD A MILLER
• 金额: $ 9.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122848
• 关键词: Age; Aging; Archives; Biochemical; Birds; Breeding; Canis familiaris; Cell Line; Cells; Cryopreserved Cell; Gerontology; Goals; Institution; Learning; Life; Lipids; Longevity; Mammals; Metals; Natural Selections; Property; Proteins; Resistance; Scientist; Stress; Sulfur Amino Acids; chelation; comparative; oxidation

Comparative Biogerontology Core: Richard Miller, Director The goal of the Comparative Biogerontology Core is to establish cryopreserved cell lines from multiple species of long-lived and short-lived birds and mammals, including long-lived and short-lived breeds of dogs, and to use these to learn more about the biochemical, biophysical, and cellular properties that are associated with exceptionally long lifespans as these have evolved under natural selection. The CBC cell archives are already being exploited by scientists at UM and at other institutions in studies of stress resistance, protein oxidation, lipid profiles, metal chelation, and sulfur amino acid metabolites as these relate to species and breed differences in aging rate and longevity.

比较生物老年学核心：理查德米勒，主任 比较生物老年学核心的目标是从多个物种的长寿和短命的鸟类和哺乳动物，包括长寿和短命的狗品种，建立冷冻保存的细胞系，并使用这些来了解更多关于生物化学，生物物理学和细胞特性，这些特性与特别长的寿命相关，因为它们在自然选择下进化。CBC细胞档案已经被UM和其他机构的科学家利用，用于研究与物种和品种相关的抗应激性，蛋白质氧化，脂质分布，金属螯合和含硫氨基酸代谢物 老化率和寿命的差异。