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Comparative Biogerontology Core

Comparative Biogerontology Core
比较生物老年学核心
批准号：
8122848
负责人：
RICHARD A MILLER
金额：
$9.34万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-01 至 2015-06-30
来源：
https://reporter.nih.gov/project-details/8122848
关键词：
AgeAgingArchivesBiochemicalBirdsBreedingCanis familiarisCell LineCellsCryopreserved CellGerontologyGoalsInstitutionLearningLifeLipidsLongevityMammalsMetalsNatural SelectionsPropertyProteinsResistanceScientistStressSulfur Amino Acidschelationcomparativeoxidation

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中文摘要
翻译
比较生物老年学核心：理查德·米勒，主任 比较生物老年学核心的目标是从多种长寿和短寿的鸟类和哺乳动物，包括长寿和短寿的狗品种中建立冷冻保存的细胞系，并利用这些细胞系来更多地了解与超长寿命相关的生化、生物物理和细胞特性，因为这些特性是在自然选择下进化的。密歇根大学和其他机构的科学家已经在利用CBC细胞档案进行抗逆性、蛋白质氧化、脂谱、金属络合和含硫氨基酸代谢产物的研究，因为这些与物种和品种有关 衰老速度和寿命的差异。
英文摘要
Comparative Biogerontology Core: Richard Miller, Director The goal of the Comparative Biogerontology Core is to establish cryopreserved cell lines from multiple species of long-lived and short-lived birds and mammals, including long-lived and short-lived breeds of dogs, and to use these to learn more about the biochemical, biophysical, and cellular properties that are associated with exceptionally long lifespans as these have evolved under natural selection. The CBC cell archives are already being exploited by scientists at UM and at other institutions in studies of stress resistance, protein oxidation, lipid profiles, metal chelation, and sulfur amino acid metabolites as these relate to species and breed differences in aging rate and longevity.
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