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Comparative Biogerontology Core

Comparative Biogerontology Core
比较生物老年学核心
批准号：
8122848
负责人：
RICHARD A MILLER
金额：
$9.34万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-01 至 2015-06-30
来源：
https://reporter.nih.gov/project-details/8122848
关键词：
AgeAgingArchivesBiochemicalBirdsBreedingCanis familiarisCell LineCellsCryopreserved CellGerontologyGoalsInstitutionLearningLifeLipidsLongevityMammalsMetalsNatural SelectionsPropertyProteinsResistanceScientistStressSulfur Amino Acidschelationcomparativeoxidation

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中文摘要
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英文摘要
Comparative Biogerontology Core: Richard Miller, Director The goal of the Comparative Biogerontology Core is to establish cryopreserved cell lines from multiple species of long-lived and short-lived birds and mammals, including long-lived and short-lived breeds of dogs, and to use these to learn more about the biochemical, biophysical, and cellular properties that are associated with exceptionally long lifespans as these have evolved under natural selection. The CBC cell archives are already being exploited by scientists at UM and at other institutions in studies of stress resistance, protein oxidation, lipid profiles, metal chelation, and sulfur amino acid metabolites as these relate to species and breed differences in aging rate and longevity.
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