Cellular and Molecular Biology of Aging

衰老的细胞和分子生物学

• 批准号: 7913489
• 负责人: RICHARD A MILLER
• 金额: $ 12.48万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7913489
• 关键词: Cellular; Molecular; Biology; Aging

DESCRIPTION (provided by applicant): The specific Aims of the Nathan Shock Center (NSC) at the University of Michigan (UM) are to: (i) facilitate and stimulate research programs in the cellular and molecular biology of aging; (ii) encourage the career development of biogerontologists, particularly junior faculty, and enrich the training environment for trainees; (iii) attract established UM faculty who are not working in biogerontology to initiate studies in this area; and (iv) utilize resources to develop collaborative relationships with other NSC's and with other universities world-wide. These aims will be achieved through the following initiatives: (i) an Administration/Enrichment Core (Faulkner) with an Internal Advisory & Core Directors' Committees; (ii) Research Development Core (Carlson) that supports workshops, pilot grants, and transitional salary support for junior faculty; (iii) five research resource cores; Transgenic Animal Models Core Camper), Aging Transgenic Rodent/Pathology Core (Keller), In Vivo Functionality Core (Metzger), and Contractility Core (Faulkner); (iv) an annual meeting of 15 senior NSC investigators to provide input to the Director and the two Committees; and (v) an External Advisory Committee. During the 9 years of NIA support, the NSC has done much to facilitate and stimulate research on aging since the participants have grown from 22 to 62 scientists at the UM and include 25 scientists at USA and foreign universities. The NSC at UM has also developed collaborative programs with the NSC at UTHSC at San Antonio and -other universities in the US and world-wide. The 62 NSC scientists investigate the molecular and cellular mechanisms of aging through multidisciplinary research in a dozen or more diverse research themes. The 15 senior scientists provide leadership to the NSC through directing cores, serving on committees, directing workshops, mentoring junior faculty and trainees, and organizing multidisciplinary collaborative research groups. The NSC has enhanced the quality and quantity of research on aging for scientists and trainees at UM and at universities world-wide.

描述（申请人提供）：密歇根大学内森休克中心（NSC）的具体目标是：（i）促进和刺激衰老细胞和分子生物学的研究计划;（ii）鼓励老年医学家，特别是初级教师的职业发展，并丰富学员的培训环境;（iii）吸引非从事生物学研究的澳大资深教职员，从事这方面的研究;及（iv）善用资源，与其他国家科学院及世界各地的大学发展合作关系。这些目标将通过以下举措实现：（i）行政/强化核心（福克纳）与内部咨询和核心董事委员会;（ii）研究发展核心（卡尔森），支持研讨会，试点赠款和初级教师的过渡性工资支持;（iii）五个研究资源核心;转基因动物模型核心Camper）、老化转基因啮齿动物/病理学核心（Keller）、体内功能性核心（Metzger）和收缩性核心（福克纳）;（iv）15名国家安全委员会高级调查员的年度会议，向主任和两个委员会提供投入;（v）外部咨询委员会。在NIA支持的9年中，NSC做了很多工作来促进和刺激老龄化研究，因为参与者从UM的22名科学家增加到62名科学家，其中包括美国和外国大学的25名科学家。澳大的国家安全委员会还与圣安东尼奥的UTHSC的国家安全委员会以及美国和世界各地的其他大学开展了合作项目。62名NSC科学家通过十几个或更多不同研究主题的多学科研究来调查衰老的分子和细胞机制。这15名资深科学家通过指导核心、在委员会任职、指导研讨会、指导初级教师和 学员，并组织多学科合作研究小组。国家安全委员会加强了 为澳大和世界各地大学的科学家和受训人员提供老龄问题研究的质量和数量。