Cellular and Molecular Biology of Aging

描述（由申请人提供）：密歇根大学（UM）内森休克中心（NSC）的具体目标是：(i)促进和刺激衰老细胞和分子生物学的研究项目；（ii）鼓励生物老年学家，特别是初级教员的职业发展，并丰富受训人员的培训环境；（iii）吸引澳大非生物老年学领域的知名教员来开展该领域的研究；（四）利用资源发展与其他国家安全委员会和世界各地其他大学的合作关系。这些目标将通过以下举措实现：(i)管理/浓缩核心（福克纳）与内部咨询和核心董事委员会；（ii）研究发展核心（Carlson），为初级教师提供研讨会、试点补助金和过渡性工资支持；（三）五个研究资源核心；转基因动物模型核心（Camper），衰老转基因啮齿动物/病理核心（Keller），体内功能核心（Metzger）和收缩性核心（Faulkner）；（iv）由15名高级国家安全委员会调查员组成的年度会议，向主任和两个委员会提供投入；(v)外部咨询委员会。在NIA支持的9年里，NSC为促进和促进衰老研究做了很多工作，因为参与研究的科学家从22名增加到62名，其中包括25名来自美国和外国大学的科学家。UM的NSC还与圣安东尼奥UTHSC的NSC以及美国和世界各地的其他大学开展了合作项目。62名国家安全委员会的科学家通过十几个或更多不同研究主题的多学科研究来调查衰老的分子和细胞机制。这15名资深科学家通过指导核心、在委员会任职、指导研讨会、指导初级教员和其他方式为国家安全委员会提供领导

DESCRIPTION (provided by applicant): The specific Aims of the Nathan Shock Center (NSC) at the University of Michigan (UM) are to: (i) facilitate and stimulate research programs in the cellular and molecular biology of aging; (ii) encourage the career development of biogerontologists, particularly junior faculty, and enrich the training environment for trainees; (iii) attract established UM faculty who are not working in biogerontology to initiate studies in this area; and (iv) utilize resources to develop collaborative relationships with other NSC's and with other universities world-wide. These aims will be achieved through the following initiatives: (i) an Administration/Enrichment Core (Faulkner) with an Internal Advisory & Core Directors' Committees; (ii) Research Development Core (Carlson) that supports workshops, pilot grants, and transitional salary support for junior faculty; (iii) five research resource cores; Transgenic Animal Models Core Camper), Aging Transgenic Rodent/Pathology Core (Keller), In Vivo Functionality Core (Metzger), and Contractility Core (Faulkner); (iv) an annual meeting of 15 senior NSC investigators to provide input to the Director and the two Committees; and (v) an External Advisory Committee. During the 9 years of NIA support, the NSC has done much to facilitate and stimulate research on aging since the participants have grown from 22 to 62 scientists at the UM and include 25 scientists at USA and foreign universities. The NSC at UM has also developed collaborative programs with the NSC at UTHSC at San Antonio and -other universities in the US and world-wide. The 62 NSC scientists investigate the molecular and cellular mechanisms of aging through multidisciplinary research in a dozen or more diverse research themes. The 15 senior scientists provide leadership to the NSC through directing cores, serving on committees, directing workshops, mentoring junior faculty and trainees, and organizing multidisciplinary collaborative research groups. The NSC has enhanced the quality and quantity of research on aging for scientists and trainees at UM and at universities world-wide.