CORE-- FACILITY FOR AGED RODENTS

CFAR，老年啮齿动物的核心设施，自1989年成立以来一直是密歇根大学克劳德佩珀中心的主要特色。CFAR将通过四个具体目标继续满足胡椒中心研究人员的需求。(1) CFAR将为所有OAIC研究者提供建议，从学生到教师，在使用啮齿动物研究衰老生物学及其在晚年疾病中的作用方面。(2) CFAR将支持特别适合研究衰老生物学及其与老年疾病关系的特殊小鼠菌落。这些包括(a) UM-HET3小鼠的遗传异质性；(b)热量限制的UM-HET3小鼠；(c)携带Pitl dw突变的长寿命Snell矮子（dw/dw）小鼠。来自这些群体的小鼠将提供给从事PESC和RCDC研究项目的教职员工，以及愿意这样做的老年医学中心教职员工

CFAR, the Core Facility for Aged Rodents, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR will continue to serve the needs of Pepper Center investigators through four Specific Aims. (1) CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease. (2) CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock; (b) calorically restricted UM-HET3 mice; and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pitl dw mutation. Mice from these colonies will be provided to faculty members working on PESC and RCDC research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds. (3) CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new fourway cross suitable for studies of late-life hearing loss, and a CAG-repeat knock-in mouse to study the timing of age-dependent motor neuron disease. (4) To nurture new rodent-based research initiatives through Core Development Projects. In the first year two such projects will be supported, one to develop instrumentation for assessment of age-dependent changes in balance and vestibular function, and the other to use calorically restricted and dwarf mice to evaluate the role of aging and anti-aging interventions in skin cell proliferation and pro-neoplastic transformation. The CFAR director will also play a role in helping to develop and design RCDC and PESC projects that make use of rodent models.