Laboratory for Anti-Geric Testing, Evaluation and Research
Laboratory for Anti-Geric Testing, Evaluation and Research
批准号:
9899403
负责人:
RICHARD A MILLER
金额:
$78.0万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-04-15 至 2019-09-29
关键词:
AcarboseAgeAgingAspirinCollaborationsCommunitiesDevelopmentDiseaseDoseDrug effect disorderElderlyEstradiolEvaluation ResearchHealthInterventionLaboratoriesLongevityMeasuresMediatingMeta-AnalysisMichiganMusPathologyPharmaceutical PreparationsPharmacologic SubstancePharmacologyPhysiologicalProtocols documentationResearchScientistSirolimusSiteStandardizationStatistical Data InterpretationTestingTexasThe Jackson LaboratoryUniversitiesexperimental studyimprovedmiddle ageprogramssextraittranslational research program
中文摘要
摘要
英文摘要
Abstract
The NIA Interventions Testing Program represents a multi-site translational research program to evaluate
agents hypothesized to extend mouse lifespan by retardation of aging or postponement of late life diseases.
Interventions proposed by multiple collaborating scientists from the research community are initially tested, in
parallel, at three sites (Jackson Laboratories, Michigan and Texas), using identical, standardized protocols,
and using sufficient numbers of genetically heterogeneous mice to provide 80% power for detecting changes in
lifespan of 10%, for either sex, after pooling data from any two of the test sites. Forty such lifespan
experiments, involving various doses of 25 distinct agents, have been initiated in the first nine years of the ITP.
Significant effects on longevity, in one or both sexes, have been documented for 5 of the tested agents:
aspirin, NDGA, rapamycin, Acarbose, and 17-α-estradiol. Initial lifespan trials are now underway for 8 agents,
as well as comprehensive analyses of the effects of rapamycin, Acarbose, and NDGA on health and on cellular
and physiological traits thought likely to mediate the beneficial effects seen. Plans for the next five year period
include additional lifespan ("Stage I") trials, detailed analyses ("Stage II") of agents found to increase lifespan,
and some increased emphasis on collaborations with other scientists skilled at evaluating traits related to
health and disease or at testing ideas about mechanisms of drug action on aging. Each of the three ITP
laboratories will bring special expertise to the effort: measures of age-sensitive traits at the Jackson
Laboratory, pathology and statistical analysis at Michigan, and pharmacology at the University of Texas.
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会议论文
Integrative Omics to enhance therapeutics development for healthy aging
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批准号:10693877
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项目类别:
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资助金额:$87.83万
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财政年份:2019
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负责人:RICHARD A MILLER
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依托单位:
Integrative Omics to enhance therapeutics development for healthy aging
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批准号:10475902
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项目类别:
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资助金额:$21.65万
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财政年份:2019
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负责人:RICHARD A MILLER
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依托单位:
Integrative Omics to enhance therapeutics development for healthy aging
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批准号:10452793
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项目类别:
-
资助金额:$89.01万
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财政年份:2019
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负责人:RICHARD A MILLER
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依托单位:
Integrative Omics to enhance therapeutics development for healthy aging
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批准号:10017120
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项目类别:
-
资助金额:$60.33万
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财政年份:2019
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负责人:RICHARD A MILLER
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依托单位:
Comparative Biogerontology Core
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批准号:8122848
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项目类别:
-
资助金额:$9.34万
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财政年份:2010
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负责人:RICHARD A MILLER
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依托单位:
Admin Core
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批准号:8122825
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项目类别:
-
资助金额:$12.92万
-
财政年份:2010
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负责人:RICHARD A MILLER
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依托单位:
CORE FACILITY FOR AGED RODENTS
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批准号:7802706
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项目类别:
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资助金额:$21.13万
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财政年份:2009
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负责人:RICHARD A MILLER
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依托单位:
Cellular and Molecular Biology of Aging
-
批准号:7913489
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项目类别:
-
资助金额:$12.48万
-
财政年份:2009
-
负责人:RICHARD A MILLER
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依托单位:
GENETIC ANALYSIS OF STRESS RESISITANCE /LOSS OF HEARING
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批准号:6966784
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项目类别:
-
资助金额:$27.49万
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财政年份:2005
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负责人:RICHARD A MILLER
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依托单位:
Long-lived mice and species as test beds for drug and pathway discovery
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批准号:10210339
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项目类别:
-
资助金额:$52.07万
-
财政年份:2004
-
负责人:RICHARD A MILLER
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依托单位:
Core Facility for Aged Rodents
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批准号:10448480
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项目类别:
-
资助金额:$13.76万
-
财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
Core Facility for Aged Rodents
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批准号:10221528
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项目类别:
-
资助金额:$16.98万
-
财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
Core Facility for Aged Rodents
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批准号:10668413
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项目类别:
-
资助金额:$14.34万
-
财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
CORE--PILOT AND EXPLORATORY STUDIES
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批准号:6847286
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项目类别:
-
资助金额:$25.12万
-
财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
Core Facility for Aged Rodents
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批准号:8877055
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项目类别:
-
资助金额:$12.94万
-
财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
Long-lived mice and species as test beds for drug and pathway discovery
-
批准号:10448348
-
项目类别:
-
资助金额:$118.66万
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财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
CORE-- FACILITY FOR AGED RODENTS
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批准号:6847281
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项目类别:
-
资助金额:$17.89万
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财政年份:2004
-
负责人:RICHARD A MILLER
-
依托单位:
Laboratory for Anti-Geric Testing, Evaluation and Resea*
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批准号:6900966
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项目类别:
-
资助金额:$52.14万
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财政年份:2003
-
负责人:RICHARD A MILLER
-
依托单位:
Laboratory for Anti-Geric Testing, Evaluation and Resea*
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批准号:7668231
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项目类别:
-
资助金额:$58.57万
-
财政年份:2003
-
负责人:RICHARD A MILLER
-
依托单位:
Laboratory for Anti-Geric Testing, Evaluation and Research
-
批准号:9063022
-
项目类别:
-
资助金额:$148.19万
-
财政年份:2003
-
负责人:RICHARD A MILLER
-
依托单位:
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