Laboratory for Anti-Geric Testing, Evaluation and Research

摘要 NIA干预测试计划代表了一项多地点转换研究计划，以评估 假想通过延缓衰老或延缓晚年疾病来延长小鼠寿命的药物。 来自研究界的多名合作科学家提出的干预措施在 同时，在三个地点(杰克逊实验室、密歇根和德克萨斯)，使用相同的标准化方案， 并使用足够数量的遗传异质小鼠来提供80%的能量来检测 在汇集了任何两个测试地点的数据后，男女的寿命都为10%。四十个这样的寿命 实验涉及25种不同剂量的不同试剂，已在ITP的前九年启动。 在被测试的5种药物中，有5种对寿命有显著影响，无论是在一种性别还是在两种性别中： 阿司匹林、脱氧核糖核酸、雷帕霉素、阿卡波糖和17-α-雌二醇。8种药物的初步寿命试验目前正在进行中， 以及综合分析雷帕霉素、阿卡波糖和NDGA对健康和细胞的影响 以及被认为可能调解所看到的有益影响的生理特征。下一个五年计划 包括额外寿命(阶段I)试验、对被发现延长寿命的制剂的详细分析(阶段II)， 一些人更加强调与其他擅长评估与以下特征相关的特征的科学家的合作 健康和疾病，或测试药物对衰老作用机制的想法。三个ITP中的每一个 实验室将为这项工作带来特殊的专业知识：杰克逊医院对年龄敏感特征的测量 密歇根大学的实验室、病理学和统计分析，以及德克萨斯大学的药理学。

Abstract The NIA Interventions Testing Program represents a multi-site translational research program to evaluate agents hypothesized to extend mouse lifespan by retardation of aging or postponement of late life diseases. Interventions proposed by multiple collaborating scientists from the research community are initially tested, in parallel, at three sites (Jackson Laboratories, Michigan and Texas), using identical, standardized protocols, and using sufficient numbers of genetically heterogeneous mice to provide 80% power for detecting changes in lifespan of 10%, for either sex, after pooling data from any two of the test sites. Forty such lifespan experiments, involving various doses of 25 distinct agents, have been initiated in the first nine years of the ITP. Significant effects on longevity, in one or both sexes, have been documented for 5 of the tested agents: aspirin, NDGA, rapamycin, Acarbose, and 17-α-estradiol. Initial lifespan trials are now underway for 8 agents, as well as comprehensive analyses of the effects of rapamycin, Acarbose, and NDGA on health and on cellular and physiological traits thought likely to mediate the beneficial effects seen. Plans for the next five year period include additional lifespan ("Stage I") trials, detailed analyses ("Stage II") of agents found to increase lifespan, and some increased emphasis on collaborations with other scientists skilled at evaluating traits related to health and disease or at testing ideas about mechanisms of drug action on aging. Each of the three ITP laboratories will bring special expertise to the effort: measures of age-sensitive traits at the Jackson Laboratory, pathology and statistical analysis at Michigan, and pharmacology at the University of Texas.