Nathan Shock Centers of Excellence in Basic Biology of Aging

内森休克衰老基础生物学卓越中心

• 批准号: 8005897
• 负责人: ARLAN G. RICHARDSON
• 金额: $ 106.71万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005897
• 关键词: Nathan; Shock; Centers; Excellence; Basic

DESCRIPTION (provided by applicant): The central premise underlying the San Antonio Nathan Shock Aging Center described in this proposal is that identifying the biological mechanisms underlying aging can best be achieved by studying animal models that show enhanced longevity. Our Center will focus its effort on providing investigators with State-of-the-art scientific infrastructure, resources, services, and unique animal models that are required in studying pertinent questions to the basic biology of aging in mammalian models of enhanced longevity. The Specific Objectives of the San Antonio Nathan Shock Aging Center are as follows: 1. To provide mammalian models of interest to investigators studying aging. The Aging Animal and Longevity Assessment Core will provide investigators with various rodent models of interest to aging, e.g., transgenic/nutritional/pharmacological manipulations, and the Comparative Biology of Aging Core will provide investigators with mammalian species with exceptionally long lifespans. 2. To provide services/resources that will allow investigators to study various molecular and physiological processes believed to play a role in aging in rodents. The Pathology, Oxidative Damage and Mitochondrial Function, Healthspan and Functional Assessment, and Research Development Cores will provide investigators with unique resources/services used to characterize the effect of the various manipulations on aging in whole animals, tissues, or cells. In addition, the Administrative/ Program Enrichment Core will provide investigators with support for data management and statistical analyses. 3. To provide assistance to faculty for developing research programs in aging. The Research Development Core will provide investigators new to aging with pilot grants and mentors to develop research programs in aging that can successfully compete for research grants from federal and private sources. 4. The Administrative/Program Enrichment Core will provide the administrative support necessary to enhance the research environment in San Antonio and to encourage collaborative research on aging among investigators at San Antonio as well as other Nathan Shock Centers and institutions. Over the past 5 years, the San Antonio Nathan Shock Aging Center has provided services to 103 investigators, and 30% of these investigators are from other research institutions.

描述（由申请人提供）：本提案中描述的圣安东尼奥内森冲击衰老中心的中心前提是，通过研究显示寿命延长的动物模型，可以最好地确定衰老的生物学机制。我们的中心将致力于为研究人员提供最先进的科学基础设施、资源、服务和独特的动物模型，这些都是研究哺乳动物长寿模型中衰老的基本生物学相关问题所必需的。