CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 早产极低出生体重（VLBW）婴儿由于其 调节脑血流（CBF）的能力不成熟。两种最常见的脑损伤 影响该患者组的是脑室内出血（IVH）和脑室周围出血（IVH）。 白质软化症（PVL）。IVH和PVL的发病高度依赖于CBF的变化。 例如，在IVH的情况下，血流量的减少可导致未成熟毛细血管的损伤， 血管在germ矩阵。如果将来血流增加，这种损伤可能导致出血。 本研究旨在探讨扩散相关光谱（DCS）是否可用于 测量这个脆弱人群的血流变化由于这些婴儿的脆弱状况， 目前还没有几种方法来评估他们的CBF。这些技术都不能监测 一直在床边。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside.