CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

极低出生体重早产儿的大脑自动调节

• 批准号: 8169051
• 负责人: Turgut Durduran
• 金额: $ 1.73万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169051
• 关键词: Affect; Blood capillaries; Blood flow; Brain Injuries; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Diffuse; Funding; Future; Grant; Hemorrhage; Homeostasis; Infant; Injury; Institution; Lead; Low Birth Weight Infant; Measures; Methods; Monitor; Patients; Periventricular Leukomalacia; Population; Premature Infant; Research; Research Personnel; Resources; Risk; Source; Spectrum Analysis; Techniques; United States National Institutes of Health; Very Low Birth Weight Infant; capillary; intraventricular hemorrhage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 早产非常低血压（VLBW）婴儿因其脑部损伤而受到重大风险 调节脑血流（CBF）的不成熟能力。最常见的两个脑损伤 影响该患者组的是脑室内出血（IVH）和脑室周围 白细胞（PVL）。 IVH和PVL的攻击高度取决于CBF的变化。 例如，在IVH的情况下，血流减少会导致未成熟毛细管的伤害 生发基质中的血管。如果将来流动增加，这种损害可能会导致出血。 这项研究旨在研究弥散相关光谱（DC）是否可以用来用于 测量这种细腻的人群中的血流变化。由于这些婴儿的脆弱状况， 很少有评估其CBF的方法。这些技术都无法监视 连续在床边。