DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 漫射光学器件作为血流的床旁监测器具有很大的应用前景， 血氧饱和度和大脑中的氧代谢。 近红外光谱（NIRS） 用于测量血氧饱和度和总血红蛋白浓度的方法 发展了一段时间，取得了重大进展。 我们的实验室已经 在这一子领域的前沿发挥主导作用。 最近我们引进了一项新技术 称为扩散相关光谱（DCS），它允许我们测量组织血流。 通过 在混合技术中将这两种方法结合在一起，我们现在可以获得更好的 基本的大脑生理学的图片，甚至可以估计脑氧代谢作为一个 大脑健康的替代标志物。 漫射光学方法的关键特征是其 作为一个连续的，非侵入性的，定量监测床旁的潜力。 我们预计， 将有未来的应用到其他大脑疾病，但由于明确的理由， 中风的巨大公共卫生意义，我们最近选择把重点放在 急性皮质卒中的管理。 通过开发这个床边监护仪，我们希望， 可以利用通常集中于脑血流优化的患者管理 并基于每个患者的潜在病理生理学进行个体化。 我们现在已经 证明了它们在完整人脑和患有脑梗死的患者的功能激活研究中的用途。 急性中风 进一步的理论、算法和技术发展是必要的 以提高数据的保真度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds a great deal of promise for implementation as a bedside monitor of blood flow, blood oxygen saturation and oxygen metabolism in the brain. Near-infrared spectroscopy (NIRS) for measuring blood oxygen saturation and total hemoglobin concentration has been under development for some time, and significant progress has been made. Our laboratory has played a leading role at the forefront of this subfield. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) that permits us to measure tissue blood flow. By combining these two methodologies together in a hybrid technology, we can now obtain a better picture of the underlying brain physiology and can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, non-invasive, quantitative monitor at the bedside. We expect that it will have future applications to other brain disorders, but because of the clear rationale and immense public health significance of stroke, we have recently elected to focus effort on the management of acute, cortical strokes. By developing this bedside monitor, we hope that patient management that often focuses on optimization of cerebral blood flow can be utilized and individualized based on the underlying pathophysiology of each patient. We have now demonstrated their use in functional activation studies of intact human brain and patients with acute stroke. Further theoretical, algorithmic, and technological developments are necessary to improve the fidelity of the data.