DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING
DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING
批准号:
7955322
负责人:
Turgut Durduran
金额:
$3.34万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-06-01 至 2010-05-31
关键词:
AcuteBedsBloodBlood flowBrainBrain DiseasesCerebrovascular CirculationCerebrumComputer Retrieval of Information on Scientific Projects DatabaseDataDevelopmentDiffuseFunctional disorderFundingFutureGrantHemoglobinHumanHybridsInstitutionLaboratoriesMagnetic ResonanceMeasuresMetabolismMethodologyMonitorNear-Infrared SpectroscopyOpticsOxygenPatientsPersonal SatisfactionPhysiologyPlayPublic HealthResearchResearch PersonnelResourcesRoleSideSourceSpectrum AnalysisStrokeSurrogate MarkersTechnologyTimeTissuesUnited States National Institutes of Healthacute strokebaseimprovednew technologyoptical imaging
中文摘要
该子项目是利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得主要资金,
因此可以在其他CRISP条目中表示。列出的机构是
中心,不一定是研究者的机构。
漫射光学器件作为血流的床旁监测器具有很大的应用前景,
血氧饱和度和大脑中的氧代谢。 近红外光谱(NIRS)
用于测量血氧饱和度和总血红蛋白浓度的方法
发展了一段时间,取得了重大进展。 我们的实验室已经
在这一子领域的前沿发挥主导作用。 最近我们引进了一项新技术
称为扩散相关光谱(DCS),它允许我们测量组织血流。 通过
在混合技术中将这两种方法结合在一起,我们现在可以获得更好的
基本的大脑生理学的图片,甚至可以估计脑氧代谢作为一个
大脑健康的替代标志物。 漫射光学方法的关键特征是其
作为一个连续的,非侵入性的,定量监测床旁的潜力。 我们预计,
将有未来的应用到其他大脑疾病,但由于明确的理由,
中风的巨大公共卫生意义,我们最近选择把重点放在
急性皮质卒中的管理。 通过开发这个床边监护仪,我们希望,
可以利用通常集中于脑血流优化的患者管理
并基于每个患者的潜在病理生理学进行个体化。 我们现在已经
证明了它们在完整人脑和患有脑梗死的患者的功能激活研究中的用途。
急性中风 进一步的理论、算法和技术发展是必要的
以提高数据的保真度。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Diffuse optics holds a great deal of promise for implementation as a bedside monitor of blood flow,
blood oxygen saturation and oxygen metabolism in the brain. Near-infrared spectroscopy (NIRS)
for measuring blood oxygen saturation and total hemoglobin concentration has been under
development for some time, and significant progress has been made. Our laboratory has played
a leading role at the forefront of this subfield. Recently, we have introduced a new technology
called diffuse correlation spectroscopy (DCS) that permits us to measure tissue blood flow. By
combining these two methodologies together in a hybrid technology, we can now obtain a better
picture of the underlying brain physiology and can even estimate brain oxygen metabolism as a
surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its
potential as a continuous, non-invasive, quantitative monitor at the bedside. We expect that it
will have future applications to other brain disorders, but because of the clear rationale and
immense public health significance of stroke, we have recently elected to focus effort on the
management of acute, cortical strokes. By developing this bedside monitor, we hope that
patient management that often focuses on optimization of cerebral blood flow can be utilized
and individualized based on the underlying pathophysiology of each patient. We have now
demonstrated their use in functional activation studies of intact human brain and patients with
acute stroke. Further theoretical, algorithmic, and technological developments are necessary
to improve the fidelity of the data.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS
-
批准号:8361964
-
项目类别:
-
资助金额:$1.54万
-
财政年份:2011
-
负责人:Turgut Durduran
-
依托单位:
DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING
-
批准号:8361959
-
项目类别:
-
资助金额:$2.31万
-
财政年份:2011
-
负责人:Turgut Durduran
-
依托单位:
CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS
-
批准号:8169051
-
项目类别:
-
资助金额:$1.73万
-
财政年份:2010
-
负责人:Turgut Durduran
-
依托单位:
DEVELOPMENT OF DIFFUSE OPTICS FOR BREAST CANCER IMAGING AND MONITORING
-
批准号:8169046
-
项目类别:
-
资助金额:$3.47万
-
财政年份:2010
-
负责人:Turgut Durduran
-
依托单位:
DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING
-
批准号:8169045
-
项目类别:
-
资助金额:$4.34万
-
财政年份:2010
-
负责人:Turgut Durduran
-
依托单位:
TECHNOLOGY TRANSFER-OPTICS
-
批准号:7955327
-
项目类别:
-
资助金额:$1.11万
-
财政年份:2009
-
负责人:Turgut Durduran
-
依托单位:
CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS
-
批准号:7955329
-
项目类别:
-
资助金额:$1.11万
-
财政年份:2009
-
负责人:Turgut Durduran
-
依托单位:
DEVELOPMENT OF DIFFUSE OPTICS FOR BREAST CANCER IMAGING AND MONITORING
-
批准号:7955323
-
项目类别:
-
资助金额:$3.34万
-
财政年份:2009
-
负责人:Turgut Durduran
-
依托单位:
DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING
-
批准号:7723823
-
项目类别:
-
资助金额:$3.26万
-
财政年份:2008
-
负责人:Turgut Durduran
-
依托单位:
CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS
-
批准号:7723830
-
项目类别:
-
资助金额:$1.09万
-
财政年份:2008
-
负责人:Turgut Durduran
-
依托单位:
BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE
-
批准号:7723829
-
项目类别:
-
资助金额:$1.63万
-
财政年份:2008
-
负责人:Turgut Durduran
-
依托单位:
TECHNOLOGY TRANSFER-OPTICS
-
批准号:7723828
-
项目类别:
-
资助金额:$1.09万
-
财政年份:2008
-
负责人:Turgut Durduran
-
依托单位:
DEVELOPMENT OF DIFFUSE OPTICS FOR BREAST CANCER IMAGING AND MONITORING
-
批准号:7723824
-
项目类别:
-
资助金额:$3.26万
-
财政年份:2008
-
负责人:Turgut Durduran
-
依托单位:
CEREBRAL AUTOREGULATION OF HEALTHY AND DISEASED BRAIN
-
批准号:7600818
-
项目类别:
-
资助金额:$3.3万
-
财政年份:2007
-
负责人:Turgut Durduran
-
依托单位:
Absolute Measurement of Cerebral Blood Flow Using Diffuse Optics
-
批准号:7477238
-
项目类别:
-
资助金额:$22.36万
-
财政年份:2007
-
负责人:Turgut Durduran
-
依托单位:
Absolute Measurement of Cerebral Blood Flow Using Diffuse Optics
-
批准号:7295902
-
项目类别:
-
资助金额:$18.9万
-
财政年份:2007
-
负责人:Turgut Durduran
-
依托单位:
海外基金