DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 漫反射光学作为血液流动的床边监测器有很大的应用前景， 大脑中的血氧饱和度和氧代谢。近红外光谱(NIRS) 用于测量血氧饱和度和总血红蛋白浓度 经过一段时间的发展，已经取得了重大进展。我们的实验室已经进行了 处于这一子领域前沿的领军人物。最近，我们引进了一项新技术 这一技术被称为漫相关光谱学，它使我们能够测量组织的血流量。通过 将这两种方法结合在一种混合技术中，我们现在可以获得更好的 大脑基本生理学的图像，甚至可以估计大脑的氧代谢作为 大脑健康的替代标记物。漫反射光学方法的主要特点是其 有可能作为床边的连续、非侵入性、定量监测。我们期待着它 将在未来应用于其他大脑疾病，但因为清楚的理论基础和 中风对公共卫生的巨大意义，我们最近选择将努力集中在 急性皮质卒中的治疗。通过开发这种床边监护仪，我们希望 可以利用通常侧重于优化脑血流的患者管理 并根据每个患者的基本病理生理学进行个性化。我们现在有了 演示了它们在完整人脑和患者的功能激活研究中的应用 急性中风。进一步的理论、算法和技术发展是必要的。 以提高数据的保真度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds a great deal of promise for implementation as a bedside monitor of blood flow, blood oxygen saturation and oxygen metabolism in the brain. Near-infrared spectroscopy (NIRS) for measuring blood oxygen saturation and total hemoglobin concentration has been under development for some time, and significant progress has been made. Our laboratory has played a leading role at the forefront of this subfield. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) that permits us to measure tissue blood flow. By combining these two methodologies together in a hybrid technology, we can now obtain a better picture of the underlying brain physiology and can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, non-invasive, quantitative monitor at the bedside. We expect that it will have future applications to other brain disorders, but because of the clear rationale and immense public health significance of stroke, we have recently elected to focus effort on the management of acute, cortical strokes. By developing this bedside monitor, we hope that patient management that often focuses on optimization of cerebral blood flow can be utilized and individualized based on the underlying pathophysiology of each patient. We have now demonstrated their use in functional activation studies of intact human brain and patients with acute stroke. Further theoretical, algorithmic, and technological developments are necessary to improve the fidelity of the data.