DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 漫射光学器件作为床旁监测器具有很大的前景，可以监测血液流动、组织 血氧饱和度和大脑中的氧代谢。 近红外光谱 （NIRS）和成像技术已经开发了一段时间，并且取得了重大进展。 被制造了。我们的实验室在这一子领域的前沿发挥了主导作用。 最近， 我们引入了一种新技术，称为扩散相关光谱（DCS）， 允许我们测量组织血流以及血氧饱和度和总血红蛋白 浓度.通过在混合技术中将这些方法组合在一起，我们现在可以 我们可以更好地了解大脑的基本生理状况， 代谢作为大脑健康的替代标志。漫射光学的关键特征 这种方法是一种潜在的连续，非侵入性，定量监测床旁。 我们 预计它将在未来应用于其他大脑疾病，但由于明确的 中风的基本原理和巨大的公共卫生意义，我们最近选择关注 致力于急性皮层中风的治疗通过开发中风监测器，我们希望 通常侧重于优化脑血流的医疗管理可以 基于每个患者的潜在病理生理学进行优化和个性化。 我们有 现在证明了它们在完整人脑和患者的功能激活研究中的用途 急性中风进一步的理论、算法和技术发展是必要的 以提高这些数据的保真度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds a great of promise as a bed-side monitor as a monitor of blood flow, tissue blood oxygen saturation and oxygen metabolism in the brain. Near-Infrared spectroscopy (NIRS) and imaging has been under development for some time, and significant progress has been made. Our laboratory has played a leading role at the forefront of this subfield. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) which permits us to measure tissue blood flow as well as blood oxygen saturation and total hemoglobin concentration. By combining these methodologies together in a hybrid technology, we can now obtain a better picture of the underlying brain physiology and we can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, noninvasive, quantitative monitor at the bedside. We expect that it will have future applications to other brain disorders, but because of the clear rationale and immense public health significance of stroke, we have recently elected to focus effort on the management of acute, cortical strokes. By developing a stroke monitor, we hope that the medical management which often focuses on optimization of cerebral blood flow can be optimized and individualized based on the underlying pathophysiology of each patient. We have now demonstrated their use in functional activation studies of intact human brain and patients with acute stroke. Further theoretical, algorithmic and technological developments are necessary to improve the fidelity of these data.