CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 早产极低出生体重（VLBW）婴儿由于其 调节脑血流（CBF）的能力不成熟。两种最常见的脑损伤 影响该患者组的是脑室内出血（IVH）和脑室周围出血（IVH）。 白质软化症（PVL）。IVH和PVL的发病高度依赖于CBF的变化。 例如，在IVH的情况下，血流量的减少可导致未成熟毛细血管的损伤， 血管在germ矩阵。如果血流增加，这种损伤可能导致出血。 未来本研究旨在探讨扩散相关光谱（DCS）是否可以 用来测量这个脆弱人群的血流变化。因为这些婴儿的脆弱 但目前尚缺乏评价脑血流的方法。这些技术都不能 在床边持续监测。DCS是在我们实验室开发的， 针对其他血流方法（如动脉自旋标记灌注MRI）进行了验证。它 是便携式的，非侵入性的，相对便宜，使其成为研究这一点的理想方法。 患者人群。使用混合扩散光学光谱（DOS）和DCS仪器来 确定头部变化期间的相对脑血流量（rCBF）和氧合变化， 离床位置。随后的验证测量也在床头进行 通过多普勒头部超声检查，并比较两种模式的结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside. DCS was developed in our lab, and it has been well validated against other blood flow methodalities such as arterial spin labelling perfusion MRI. It is portable, non-invasive, and relatively inexpensive, making it an ideal method to study this patient population. A hybrid diffuse optical spectroscopy (DOS) and DCS instrument is used to determine relative cerebral blood flow (rCBF) and oxygenation changes during changes in head- of-bed position. Subsequent validation measurements are also performed during head-of-bed changes by Doppler head ultrasound, and the results from the two modalities were compared.