CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 早产儿极低出生体重(VLBW)婴儿因其 不成熟的脑血流调节能力(CBF)。两种最常见的脑损伤 影响这一组患者的是脑室内出血(IVH)和脑室周围 白质软化症(PVL)。IVH和PVL的起始点高度依赖于CBF的变化。 例如，在IVH的情况下，血流量的减少可能会导致未成熟的毛细血管损伤。 生发基质中的血管。如果血液中的流量增加，这种损伤可能会导致出血 未来。本研究旨在探讨漫相关光谱分析是否可以 用来测量这一脆弱人群的血流变化。因为这些婴儿的脆弱 在这种情况下，评估其CBF的方法很少。这些技术都不能 在床边持续监测。本实验室自行开发了集散控制系统，并取得了良好的效果 与动脉自旋标记灌注MRI等其他血流方法对比验证。它 是便携的，非侵入性的，相对便宜的，使其成为研究这一问题的理想方法 病人群体。利用漫反射光谱(DOS)和集散控制系统(DCS)相结合的方法 测定头颅改变时的相对脑血流量(RCBF)和氧合变化。 卧床姿势。随后的验证测量也在床头期间执行 并对两种方法的检测结果进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside. DCS was developed in our lab, and it has been well validated against other blood flow methodalities such as arterial spin labelling perfusion MRI. It is portable, non-invasive, and relatively inexpensive, making it an ideal method to study this patient population. A hybrid diffuse optical spectroscopy (DOS) and DCS instrument is used to determine relative cerebral blood flow (rCBF) and oxygenation changes during changes in head- of-bed position. Subsequent validation measurements are also performed during head-of-bed changes by Doppler head ultrasound, and the results from the two modalities were compared.