DEVELOPMENT OF DIFFUSE OPTICS FOR BED-SIDE MONITORING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 漫射光学器件有望作为血流、血氧的床边监测器 饱和度和大脑中的氧代谢。漫射光谱（DOS），用于测量 血氧饱和度和总血红蛋白浓度，一直在开发中， 已经取得了一些时间和重大进展。我们的实验室在全球范围内发挥了主导作用。 这项活动的最前沿。最近，我们引入了一种新的技术，称为扩散相关 光谱学（DCS）允许光学测量深层组织血流。通过组合这些 两种方法（DOS/DCS）在一个单一的混合设备，我们可以得到一个更好的图片 甚至可以估算脑氧代谢作为替代 大脑健康的标志漫射光学方法的关键特征是其作为一种 在床旁进行连续、无创、定量监测。我们希望未来的应用 关于其他大脑疾病将实现，但由于明确的理由和巨大的 中风的公共卫生意义，我们选择集中大量的精力在管理 急性皮层中风有了这款床旁监护仪，患者管理通常侧重于 脑血流的优化可以基于潜在的病理生理学而个体化 每一个病人。到目前为止，用于完整人脑和患者的功能激活研究 急性中风的症状进一步的算法和技术发展是 必须提高数据的保真度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diffuse optics holds promise for implementation as a bedside monitor of blood flow, blood oxygen saturation and oxygen metabolism in the brain. Diffuse optical spectroscopy (DOS), for measuring blood oxygen saturation and total hemoglobin concentration, has been under development for some time and significant progress has been made. Our laboratory has played a leading role at the forefront of this activity. Recently, we have introduced a new technology called diffuse correlation spectroscopy (DCS) that permits optical measurement deep tissue blood flow. By combining these two methodologies (DOS/DCS) in a single hybrid device, we can obtain a better picture of the underlying brain physiology and can even estimate brain oxygen metabolism as a surrogate marker of cerebral well-being. The key feature of the diffuse optical approach is its potential as a continuous, non-invasive, quantitative monitor at the bedside. We expect that future applications pertaining to other brain disorders will be realized, but because of the clear rationale and immense public health significance of stroke, we have elected to focus substantial effort on the management of acute, cortical strokes. With this bedside monitor, patient management that often focuses on optimization of cerebral blood flow can be individualized based on the underlying patho-physiology of each patient. Thus far, use in functional activation studies of intact human brain and in patients with acute stroke has been demonstrated. Further algorithmic and technological developments are necessary to improve the fidelity of the data.