SODIUM MRI OF ARTICULAR CARTILAGE OF HUMAN KNEE AT 7T

7T 人膝关节软骨的钠 MRI

• 批准号: 8169070
• 负责人: VICTOR KASSEY
• 金额: $ 1.73万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169070
• 关键词: Affect; Arthritis; Cartilage; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Diagnostic; Disease; Funding; Future; Goals; Grant; Histology; Human; Image; Institution; Knee; Magnetic Resonance Imaging; Maps; Mechanical Stress; Pain; Patients; Proteoglycan; Relaxation; Research; Research Personnel; Resolution; Resources; Shock; Signal Transduction; Sodium; Source; Spatial Distribution; Specificity; Stress; Tissues; United States National Institutes of Health; articular cartilage; bone; disability; experience; in vivo; insight; knee replacement arthroplasty; pressure; prevent; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The function of articular cartilage is to withstand high pressure, absorb shock and prevent the transmission of stress to the underlying bone. Osteoarthritis is a very common disease characterized by progressive degeneration of articular cartilage experienced as pain and disability. Early arthritis is typified by loss of the proteoglycan (PG) "springs" that allow for cartilage to absorb everyday mechanical stress. In the past, it has been shown that both T1¿ relaxation and sodium concentration mapping by magnetic resonance imaging is sensitive to the concentration of proteoglycan in tissue. The purpose of this study is to correlate T1¿ relaxometry with sodium concentrations in arthritic cartilage removed during knee replacements. These results will enable us to determine the specificity of T1¿ MRI towards PG. Sodium MRI, with extensive signal averaging in ex vivo tissue, gives us the ability to generate high resolution, sameslice maps that are impossible to generate in vivo. These results are then compared with histology to make a clear correlation between MRI and histological findings. With these studies we hope to gain additional insight into the spatial distribution and progressive loss of PG in arthritis. These insights will be useful for the tracking of osteoarthritis and its treatments in affected patients. Future goal is to get co-registered sodium and T1¿ In vivo images for detecting early Osteoarthritis for increased diagnostic reliability.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 关节软骨的功能是承受高压，吸收冲击和防止关节软骨损伤。 应力传递到下面的骨头。骨关节炎是一种非常常见的疾病 以关节软骨的进行性退化为特征，表现为疼痛和残疾。 早期关节炎的典型特征是蛋白聚糖（PG）“弹簧”的丢失， 来吸收日常的机械压力在过去，已经表明，T1和T2都是 磁共振成像的弛豫和钠浓度绘图对 组织中蛋白聚糖的浓度。本研究的目的是将T1 <$relaxometry 关节炎软骨中的钠浓度在膝关节置换术中被去除。这些 结果将使我们能够确定T1 <$MRI对PG.钠MRI的特异性， 在离体组织中广泛的信号平均，使我们能够产生高分辨率， 不可能在体内生成的相同切片图。然后将这些结果与 组织学检查以明确MRI和组织学结果之间的相关性。通过这些研究 我们希望获得更多关于关节炎中PG的空间分布和进行性丢失的信息。 这些见解将有助于跟踪骨关节炎及其治疗的影响， 患者未来的目标是获得钠和T1共配准的体内图像，用于早期检测 骨关节炎以提高诊断可靠性。