CEST AND T1? IMAGING OF HUMAN KNEE CARTILAGE AT 7T

CEST 和 T1？

• 批准号: 8361976
• 负责人: VICTOR KASSEY
• 金额: $ 3.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361976
• 关键词: Affect; Arthritis; Cartilage; Chemicals; Degenerative polyarthritis; Diagnostic; Disease; Funding; Future; Goals; Grant; Human; Image; Imaging Techniques; Knee; Magnetic Resonance; Magnetic Resonance Imaging; Mechanical Stress; National Center for Research Resources; Pain; Patients; Principal Investigator; Proteoglycan; Research; Research Infrastructure; Resources; Shock; Sodium; Source; Spatial Distribution; Specificity; Stress; Techniques; Tissues; United States National Institutes of Health; articular cartilage; bone; cost; disability; experience; in vivo; insight; optical imaging; pressure; prevent; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The function of articular cartilage is to withstand high pressure, absorb shock and prevent the transmission of stress to the underlying bone. Osteoarthritis is a very common disease characterized by progressive degeneration of articular cartilage experienced as pain and disability. Early arthritis is typified by loss of the proteoglycan (PG) "springs" that allow for cartilage to absorb everyday mechanical stress. In the past, T1¿ and sodium magnetic resonance imaging techniques have been used to study articular cartilage, which is sensitive to the concentration of proteoglycan in tissue. The purpose of the present study is to exploit inherent contrast with chemical exchange saturation transfer (CEST) technique and correlate with T1¿ relaxometry in arthritic cartilage of human knees. These results will enable us to determine specificity of T1¿ MRI towards PG in different conditions. With these studies, we hope to gain additional insight into the spatial distribution and progressive loss of PG in arthritis. These insights will be useful for the tracking of osteoarthritis and its treatments in affected patients. Future goal is to get co-registered CEST and T1¿ In vivo images for detecting early Osteoarthritis for increased diagnostic reliability.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 关节软骨的功能是承受高压、吸收冲击、防止关节变形。 将压力传递到下面的骨骼。骨关节炎是一种非常常见的疾病 其特征是关节软骨进行性退化，表现为疼痛和 残疾。早期关节炎的典型特征是蛋白多糖 (PG)“泉源”的丧失 软骨吸收日常机械应力。过去，T1¿和钠磁 共振成像技术已用于研究关节软骨， 对组织中蛋白多糖的浓度敏感。本研究的目的 是利用与化学交换饱和转移（CEST）技术的固有对比 并与人类膝盖关节炎软骨中的 T1¿ 松弛测量相关。这些结果将 使我们能够确定不同条件下 T1¿ MRI 对 PG 的特异性。有了这些 研究中，我们希望对空间分布和渐进损失有更多的了解 PG 在关节炎中的作用。这些见解将有助于追踪骨关节炎及其相关疾病 受影响患者的治疗。未来的目标是在体内获得CEST和T1的共同注册 用于检测早期骨关节炎的图像以提高诊断可靠性。