Adipocytes and Botanicals/Jacequeline M. Stephens
脂肪细胞和植物药/Jacequeline M. Stephens
基本信息
- 批准号:8006956
- 负责人:
- 金额:$ 18.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-04-01 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In preliminary studies we have identified botanicals that have favorable (selected Artemisia species) and unfavorable (St. John's Wort) effects on adipocyte development and function. The overall goal of project 2 is to study these specific botanicals to investigate the cellular mechanisms by which these botanicals regulate adipocyte function and influence whole body, insulin action. This goal is in harmony with the overall goal ofthe Center to provide a comprehensive evaluation of botanicals in addressing the pathophysiologic mechanisms that lead to the development of insulin resistance and the metabolic syndrome. Our studies will focus on adipocj/te development, adipokines, and insulin action. We will also fulfill the aims ofthe center by continuing active collaborations with project leaders and core participants. Additionally, we will perform studies to identify the bioactive constituents of Artemisia and SJW extracts, and to elucidate how these compounds effect adipocyte development and insulin
action.
在初步研究中,我们已经确定了对脂肪细胞发育和功能具有有利(选定的蒿属物种)和不利(圣约翰草)作用的植物。项目2的总体目标是研究这些特定的植物药,以调查这些植物药调节脂肪细胞功能和影响全身胰岛素作用的细胞机制。这一目标与该中心的总体目标是一致的,即提供一个全面的植物药评价,以解决导致胰岛素抵抗和代谢综合征发展的病理生理机制。我们的研究将集中在脂肪发育,脂肪因子和胰岛素的作用。我们还将继续与项目负责人和核心参与者积极合作,实现中心的目标。此外,我们将进行研究,以确定蒿属和SJW提取物的生物活性成分,并阐明这些化合物如何影响脂肪细胞发育和胰岛素
行动上
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
William T. Cefalu其他文献
Canagliflozin Demonstrates Durable Glycemic Improvements Over 104 Weeks Compared with Glimepiride in Subjects with Type 2 Diabetes Mellitus on Metformin
- DOI:
10.1016/j.jcjd.2013.08.081 - 发表时间:
2013-10-01 - 期刊:
- 影响因子:
- 作者:
Lawrence A. Leiter;Gisle Langslet;William T. Cefalu;Kun Ho Yoon;Pablo Arias;John Xie;Dainus Balis;Dawn Millington;Frank Vercruysse;William Canovatchel;Gary Meininger - 通讯作者:
Gary Meininger
Insulin Sensitizers Versus Secretagogues as First‐Line Therapy for Diabetes: Rationale for Clinical Choice
胰岛素增敏剂与促泌剂作为糖尿病一线治疗:临床选择的理由
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Robert J. Richards;L. Yvonne Melendez;William T. Cefalu - 通讯作者:
William T. Cefalu
Clinical validation of a second-generation fructosamine assay.
第二代果糖胺测定的临床验证。
- DOI:
- 发表时间:
1991 - 期刊:
- 影响因子:9.3
- 作者:
William T. Cefalu;William T. Cefalu;A. Bell;A. Bell;Marie Petty;Marie Petty;Camille Izlar;Camille Izlar;Jeffrey A. Smith;Jeffrey A. Smith - 通讯作者:
Jeffrey A. Smith
The new diabetes inhalers: New tools for the clinician
- DOI:
10.1007/s11892-007-0026-2 - 发表时间:
2007-06-01 - 期刊:
- 影响因子:6.400
- 作者:
William T. Cefalu - 通讯作者:
William T. Cefalu
Correlation of Serum Fructosamine Activity in Type i Diabetic Children
- DOI:
10.1097/00000441-198904000-00009 - 发表时间:
1989-04-01 - 期刊:
- 影响因子:
- 作者:
William T. Cefalu;Etienne Mejia;George R. Puente;Debbie Fleishhacker;Kathryn Macaulay - 通讯作者:
Kathryn Macaulay
William T. Cefalu的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('William T. Cefalu', 18)}}的其他基金
HRT TO AUGMENT LOSS OF VISCERAL FAT AND IMPROVE INSULIN SENSITIVITY
激素替代疗法可增加内脏脂肪的减少并提高胰岛素敏感性
- 批准号:
7206931 - 财政年份:2005
- 资助金额:
$ 18.95万 - 项目类别:
Artemisia SP and Insulin Action/William T. Cefalu
蒿 SP 和胰岛素作用/William T. Cefalu
- 批准号:
8006899 - 财政年份:2005
- 资助金额:
$ 18.95万 - 项目类别:
Integrative Biology Core/Thomas W. Gettys
综合生物学核心/Thomas W. Gettys
- 批准号:
8339167 - 财政年份:2005
- 资助金额:
$ 18.95万 - 项目类别:
Botanical Research Core/David M. Ribnicky
植物研究核心/David M. Ribnicky
- 批准号:
8006962 - 财政年份:2005
- 资助金额:
$ 18.95万 - 项目类别:
Chromium, Cellular Energy Status, Whole Body Energy Bala
铬、细胞能量状态、全身能量巴拉
- 批准号:
6963437 - 财政年份:2005
- 资助金额:
$ 18.95万 - 项目类别:
相似国自然基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制
- 批准号:81970721
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
相似海外基金
New development of cellular regeneration therapy in jaw bone using stem cells derived from adipocytes jaw bone
利用颌骨脂肪细胞来源的干细胞进行颌骨细胞再生治疗的新进展
- 批准号:
23K16058 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
A novel mechanism of insulin resistance mediated by uric acid metabolism in adipocytes
脂肪细胞尿酸代谢介导胰岛素抵抗的新机制
- 批准号:
23K10969 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Hypertrophic adipocytes as biophysical mediators of breast cancer progression
肥大脂肪细胞作为乳腺癌进展的生物物理介质
- 批准号:
10751284 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Elucidation of mechanisms for conversion of adipocytes to cancer-associated fibroblasts in osteosarcoma microenvironment
阐明骨肉瘤微环境中脂肪细胞转化为癌症相关成纤维细胞的机制
- 批准号:
23K19518 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Study on UCP-1 independent metabolic regulation by brown adipocytes
棕色脂肪细胞对UCP-1独立代谢调节的研究
- 批准号:
23K18303 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Development of adipocytes for gene therapy that avoids cellular stress due to overexpression of therapeutic proteins
开发用于基因治疗的脂肪细胞,避免因治疗蛋白过度表达而造成的细胞应激
- 批准号:
23H03065 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional analysis of bitter taste receptors in adipocytes and hepatocytes
脂肪细胞和肝细胞中苦味受体的功能分析
- 批准号:
23K05107 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
NKA/CD36 signaling in adipocytes promotes oxidative stress and drives chronic inflammation in atherosclerosis
脂肪细胞中的 NKA/CD36 信号传导促进氧化应激并驱动动脉粥样硬化的慢性炎症
- 批准号:
10655793 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
The mechanisms of the signal transduction from brown adipocytes to afferent neurons and its significance.
棕色脂肪细胞向传入神经元的信号转导机制及其意义。
- 批准号:
23K05594 - 财政年份:2023
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
NKT cell activation depend on lipid accumulation in adipocytes
NKT 细胞的激活取决于脂肪细胞中的脂质积累
- 批准号:
22K08679 - 财政年份:2022
- 资助金额:
$ 18.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)