Adipocytes and Botanicals/Jacequeline M. Stephens

在初步研究中，我们已经确定了对脂肪细胞发育和功能有有利影响(选定的蒿属植物)和不利影响(圣约翰草)的植物药物。项目2的总体目标是研究这些特定的植物药物，以探讨这些植物药物调节脂肪细胞功能和影响全身胰岛素作用的细胞机制。这一目标与该中心的总体目标是一致的，即在解决导致胰岛素抵抗和代谢综合征发展的病理生理机制方面提供植物药物的全面评估。我们的研究将集中在脂肪发育、脂肪因子和胰岛素的作用上。我们还将通过继续与项目负责人和核心参与者积极合作来实现中心的目标。此外，我们将进行研究，以确定蒿属和生姜提取物的生物活性成分，并阐明这些化合物如何影响脂肪细胞发育和胰岛素。 行动。

In preliminary studies we have identified botanicals that have favorable (selected Artemisia species) and unfavorable (St. John's Wort) effects on adipocyte development and function. The overall goal of project 2 is to study these specific botanicals to investigate the cellular mechanisms by which these botanicals regulate adipocyte function and influence whole body, insulin action. This goal is in harmony with the overall goal ofthe Center to provide a comprehensive evaluation of botanicals in addressing the pathophysiologic mechanisms that lead to the development of insulin resistance and the metabolic syndrome. Our studies will focus on adipocj/te development, adipokines, and insulin action. We will also fulfill the aims ofthe center by continuing active collaborations with project leaders and core participants. Additionally, we will perform studies to identify the bioactive constituents of Artemisia and SJW extracts, and to elucidate how these compounds effect adipocyte development and insulin action.