TRANSCRIPT ANALYSIS OF LUNG CANCER CELL LINES

肺癌细胞系的转录分析

• 批准号: 8170795
• 负责人: KELLEY W. MOREMEN
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170795
• 关键词: Cancer cell line; Computer Retrieval of Information on Scientific Projects Database; Funding; Genes; Grant; Institution; Lead; Link; Malignant neoplasm of lung; Pathway interactions; Research; Research Personnel; Resources; Source; Transcript; United States National Institutes of Health; glycosylation; high throughput screening; inhibitor/antagonist; lipooligosaccharide

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project involves evaluating the transcript abundance for genes involved in N-linked glycosylation, specifically the Lipid-linked Oligosaccharide (LLO) pathway genes, in lung cancer cell lines. Dr. Contessa has generated a high throughput screen for inhibitors of N-linked glycosylation and pairing his functional analysis with the transcript analysis will lead to a better understanding of the effects of the inhibitors on transcript abundance levels.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目涉及评估肺癌细胞系中参与N-连接糖基化的基因的转录丰度，特别是脂质连接寡糖（LLO）途径基因。 Contessa博士对N-连接糖基化抑制剂进行了高通量筛选，并将其功能分析与转录分析相结合，将有助于更好地了解抑制剂对转录丰度水平的影响。