INCORPORATION OF SPIN-LABELED ORGANIC MOLECULES INTO CARBON NANOTUBES

将自旋标记有机分子掺入碳纳米管

• 批准号: 8364060
• 负责人: BORIS G DZIKOVSKI
• 金额: $ 0.08万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364060
• 关键词: Attention; Biodegradable microsphere; Blood Circulation; Blood Vessels; Cancerous; Carbon; Carbon Nanotubes; Drug Controls; Drug Delivery Systems; Electron Spin Resonance Spectroscopy; Electronics; Funding; Grant; Mechanics; Microscopy; Nanotechnology; National Center for Research Resources; Optics; Pharmaceutical Preparations; Principal Investigator; Publishing; Research; Research Infrastructure; Resolution; Resources; Science; Source; Spin Labels; Techniques; Technology; Tissues; United States National Institutes of Health; cancer therapy; cost; design; electrical property; nanomaterials; nanoparticle; new technology; prospective; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Carbon nanotubes (CNT) are allotropes of carbon. They are extremely thin hollow cylinders made of carbon atoms. Unique mechanical and electrical properties of CNT make them potentially useful in many applications in nanotechnology, electronics, optics and other fields of material science. Recently, they have attracted attention as prospective drug delivery agents, especially in cancer treatment. Leaky blood vessels in tumors cause accumulation of nanoparticles introduced into the bloodstream in the cancerous tissue. Understanding incorporation of organic molecules in carbon nanotubes and delivery of the former can help in designing new drugs and treatment techniques. ACERT published a successful study on control drug release from micro-scale biodegradable microspheres. Studying drug release from nano-materials will be a further implementation of unique opportunities provided by ESR spectroscopy in general and novel technologies being developed in ACERT, such as high resolution ESR microscopy.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 碳纳米管（CNT）是碳的同素异形体。它们是由碳原子组成的极薄的空心圆柱体。碳纳米管独特的机械和电学性能使其在纳米技术、电子学、光学和其他材料科学领域的许多应用中具有潜在的用途。近年来，它们作为有前景的药物递送剂，特别是在癌症治疗中，引起了人们的关注。肿瘤中的血管渗漏导致引入到癌组织中的血流中的纳米颗粒的积累。了解有机分子在碳纳米管中的结合和前者的递送可以帮助设计新的药物和治疗技术。ACERT发表了一项成功的研究，控制药物释放的微尺度生物降解微球。研究纳米材料的药物释放将进一步实现ESR光谱学提供的独特机会，以及ACERT正在开发的新技术，如高分辨率ESR显微镜。