BETA CELL METABOLISM

β细胞代谢

• 批准号: 8171637
• 负责人: CHRISTOPHER B NEWGARD
• 金额: $ 1.05万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171637
• 关键词: Academic Medical Centers; Area; Beta Cell; Biochemical; Biology; Cell model; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Disease; Funding; Genetic Engineering; Glucose; Goals; Grant; Institution; Islets of Langerhans; Laboratories; Medical center; Metabolism; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Program Research Project Grants; Research; Research Personnel; Resources; Source; Technology; Texas; United States National Institutes of Health; Universities; gene discovery; insulin secretion; interdisciplinary approach; new technology; novel; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Newgard laboratory uses interdisciplinary approaches for the study of the biochemical and molecular mechanisms involved in glucose-stimulated insulin secretion, including development of novel cellular models, gene discovery and genetic engineering. The overarching goal of this program project grant (PPG) continues to be the development of novel therapies for type 2 diabetes. The program has evolved from its genesis in 1999 as a collaboration between three research Centers within the University of Texas Southwestern Medical Center in Dallas (UTSWMC) to its current format, involving collaboration of four Centers located at UTSWMC and Duke University Medical Center. The program will continue with its unique format of melding projects on diabetes mechanisms with projects focused on development of new technologies for studying and treating the disease. In the past funding cycle, the most compelling advances have occurred in the area of pancreatic islet biology and related technologies.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 纽加德实验室使用跨学科方法研究葡萄糖刺激的胰岛素分泌所涉及的生化和分子机制，包括开发新的细胞模型、基因发现和基因工程。该计划项目赠款(PPG)的首要目标仍然是开发治疗2型糖尿病的新疗法。该计划从1999年作为德克萨斯大学达拉斯西南医学中心(UTSWMC)内三个研究中心之间的合作发展到目前的形式，包括位于UTSWMC的四个中心和杜克大学医学中心的合作。该计划将继续其独特的形式，将糖尿病机制项目与专注于研究和治疗这种疾病的新技术开发的项目融合在一起。在过去的供资周期中，最引人注目的进展出现在胰岛生物学和相关技术领域。