FASEB SRC on Glucose transport:Gateway to Metabolic Systems Biology

FASEB SRC 关于葡萄糖转运：代谢系统生物学的门户

• 批准号: 8977103
• 负责人: CHRISTOPHER B NEWGARD
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-19 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8977103
• 关键词: Academia; American; Area; Award; Biology; Cardiovascular Diseases; Cell physiology; Cells; Chronic Disease; Cloning; Collaborations; Communication; Data; Databases; Development; Diabetes Mellitus; Disabled Persons; Disease; Ensure; Event; Faculty; Functional disorder; Funding; Glucose; Glucose Transporter; Goals; Growth; Health; Hour; Industry; Institution; Lead; Life; Link; Maintenance; Malignant Neoplasms; Metabolic; Metabolic Control; Metabolic Diseases; Metabolism; Methods; Minority; Montana; Muscle; Myocardium; National Institute of Diabetes and Digestive and Kidney Diseases; Nutrient; Obesity; Participant; Pathogenesis; Performance; Pharmacologic Substance; Physiology; Protein Isoforms; Recording of previous events; Regulation; Research; Research Personnel; Running; Scheme; Scientist; Series; Signal Transduction; Skeletal Muscle; Societies; Staging; Students; Systems Biology; Technology; Testing; United States National Institutes of Health; Woman; abstracting; career; combat; forging; glucose transport; glucose uptake; high standard; lectures; meetings; muscle metabolism; new therapeutic target; posters; public health relevance; symposium; tool; uptake; volunteer

 DESCRIPTION (provided by applicant): Glucose uptake into cells is a central component of metabolism and energetics. The mechanisms by which glucose-derived energy is used for specific cellular functions such as growth, proliferation and maintenance, and how altered regulation can contribute to development of cardiometabolic diseases and cancer are critically important questions. It is necessary to explore these questions with a broad perspective, in which whole body and cellular mechanisms of cell signaling, nutrient uptake, and metabolism are integrated. Major advances in technology for investigating metabolism-driven chronic diseases have occurred in the past years, including advent of sophisticated platforms for systems biology. These developments facilitate approaches to understanding metabolic complexity that can include hypothesis-driven and database-driven discovery, but also requiring tools to enable hypothesis testing. In the face of these rapid changes, the proposed FASEB summer conference on "Glucose Transport: Gateway to Metabolic Systems Biology" seems particularly timely and important for maximizing communication among groups, forging collaborations, and facilitating progress in the field. Funding from NIDDK will ensure that this series, among the most long-lived in FASEB conference history, will continue to contribute to our understanding of metabolic physiology and its links to disease pathophysiology, while also serving as a vehicle to encourage and nurture young and emerging scientists in the field.

 描述（由申请人提供）： 葡萄糖吸收对细胞是代谢和能量的核心成分。葡萄糖衍生能量用于特定细胞功能（例如生长，增殖和维持）以及调节改变如何有助于心脏代谢疾病和癌症的发展是至关重要的问题，这是至关重要的问题。有必要以广泛的视角探索这些问题，在这些问题中，整个身体和细胞信号，养分摄取和代谢的机制都是整合的。在过去几年中，研究了代谢驱动的慢性疾病的技术的重大进展，包括系统生物学的复杂平台的发展。这些发展促进了理解代谢复杂性的方法，其中可能包括假设驱动和数据库驱动的发现，还需要工具来实现假设检验。面对这些快速变化，拟议的FASEB夏季会议“葡萄糖运输：代谢系统生物学的门户”似乎对于最大程度地且重要，对于最大程度地提高了群体之间的沟通，锻造合作和支持该领域的进步。 NIDDK的资金将确保该系列在FaseB会议历史上最长期以来，将继续为我们对代谢生理学的理解及其与疾病病理生理学的联系做出贡献，同时也是鼓励和护理该领域的年轻和新兴科学家的工具。