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North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

基本信息

批准号：
10609100
负责人：
CHRISTOPHER B NEWGARD
金额：
$ 18.53万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-07 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10609100
关键词：
Address Bioinformatics Biological Biological Assay Blood Body Fluids Cardiometabolic Disease Chemicals Collaborations Computational Biology Computer Analysis Data Analyses Dedications Development Diabetes Mellitus Disease Educational workshop Elements Ensure Faculty Feces Genomics Human Resources Incidence Infrastructure Institution Insulin Resistance Investments Knowledge Laboratories Letters Light Measurement Measures Metabolic Methods Mission Molecular North Carolina Obesity Organism Phenotype Physiological Physiology Process Proteomics Recording of previous events Reproducibility Research Research Design Research Personnel Research Support Science Seminal Services Severities Skeletal Muscle Students Surveys Technology Tissue Extracts Tissues Urine Work biomarker discovery cardiovascular risk factor chemical property diabetes pathogenesis experience forest genomic platform instrument insulin secretion medical schools member metabolome metabolomics muscle physiology nanomolar outreach predictive marker programs sample collection transcriptomics

项目摘要

PROJECT SUMMARY/ABSTRACT – METABOLOMICS CORE Comprehensive metabolic analysis, or “metabolomics”, is a technology that defines the chemical phenotype of living systems. Given that metabolic fluxes and metabolite levels are downstream of genomic, transcriptomic, and proteomic variability, metabolomics provides a highly integrated profile of biological status. As such, it has unique potential for discovery of biomarkers that predict disease incidence, severity, and progression, and for casting new light on underlying mechanistic abnormalities. Metabolomic analyses are challenging, however, due to the complexity inherent in measuring large numbers of intermediary metabolites with diverse chemical properties in a quantitatively rigorous and reproducible fashion. The DMPI Metabolomics Core Lab has a long history of collaborative research and has established a strong and reliable infrastructure for conducting measurements for investigators at Duke and at outside institutions. Thus, it is well poised to become the NCDRC Metabolomics Core. While Duke has world-renowned facilities for metabolomics, its use by diabetes investigators outside of Duke (such as WF and UNC researchers) has been limited by bottlenecks, particularly in the analysis and interpretation of data, which the NCDRC seeks to address by establishing the NCDRC Metabolomics Core with support from Research Navigators.

项目总结/摘要-代谢组学核心综合代谢分析，或“代谢组学”，是一种定义代谢产物的化学表型的技术。生活系统鉴于代谢通量和代谢物水平是基因组、转录组、和蛋白质组变异性，代谢组学提供了一个高度整合的生物学状态的概况。因此，发现预测疾病发生率、严重程度和进展的生物标志物的独特潜力，为潜在的机械异常提供了新的线索代谢组学分析具有挑战性，然而，由于测量大量具有不同化学物质的中间代谢物的固有复杂性以定量的严格和可重复的方式来测量性能。DMPI代谢组学核心实验室有一个长期的合作研究的历史，并建立了强大而可靠的基础设施，为杜克和外部机构的研究人员提供测量。因此，它已做好充分准备，成为全国儿童权利委员会代谢组学核心。虽然杜克大学拥有世界知名的代谢组学设施，但糖尿病患者杜克以外的研究人员（如WF和EMBA研究人员）受到瓶颈的限制，特别是在数据的分析和解释方面，国家疾病预防和控制委员会试图通过建立国家疾病预防和控制委员会来解决这一问题。代谢组学核心与研究导航的支持。