DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS

用于人类遗传分析的便携式计算机程序的开发

• 批准号: 7723433
• 负责人: Robert C. Elston
• 金额: $ 46.37万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723433
• 关键词: Address; Code; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Computers; Data; Development; Family; Funding; Grant; Human; Institution; Java; Learning; Linux; Modeling; Operating System; Phenotype; Research; Research Personnel; Resources; Running; Source; Time; United States National Institutes of Health; base; computer program; design; genetic analysis; genetic epidemiology; graphical user interface; programs; simulation; syntax; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The S.A.G.E. (Statistical Analysis for Genetic Epidemiology) computer program package provides researchers with the tools necessary for various types of statistical genetic analysis of human family data. Prior to the funding of this resource, few such computer programs were available, and those in existence were usually poorly documented and not easily transportable from one type of computer to another. This subproject has addressed these problems by developing computer programs for genetic analysis that are well documented and portable between different computers and operating systems. S.A.G.E. version 5.4 was released in July, 2007 and new releases of the software are posted, on average, twice per year. The program is constructed from compiled C++ code and runs on Windows, Unix/Linux, Solaris and MacOS platforms. The software includes a Java-based graphical user interface (GUI) designed to eliminate the need for new users to learn the complex syntax for program configuration. At the same time, advanced users may still create and analyze very sophisticated models using either the GUI or the more traditional command line version of the software. The next major release (version 6.0) is expected to include a new utility for managing high-throughput marker phenotypes, a restored and enhanced version of RELPAL, significant improvements to ASSOC, and an efficient, generalized simulation program.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 特别行动小组遗传流行病学统计分析（Statistical Analysis for Genetic Epidemiology）计算机程序包为研究人员提供了对人类家族数据进行各种类型的统计遗传分析所必需的工具。 在为这一资源提供资金之前，几乎没有这样的计算机程序，现有的计算机程序通常记录不全，而且不容易从一种计算机转移到另一种计算机。 该子项目通过开发用于遗传分析的计算机程序来解决这些问题，这些程序有很好的文档记录，并且可以在不同的计算机和操作系统之间移植。 SAGE 5.4版于2007年7月发布，平均每年发布两次新版本。 该程序由编译的C++代码构建，可在Windows、Unix/Linux、Solaris和MacOS平台上运行。 该软件包括一个基于Java的图形用户界面（GUI），旨在消除新用户学习程序配置的复杂语法的需要。 同时，高级用户仍然可以使用GUI或更传统的命令行版本的软件创建和分析非常复杂的模型。 下一个主要版本（6.0版）预计将包括一个新的实用程序，用于管理高通量标记表型，恢复和增强版本的ASPPAL，ASSOC的显着改进，以及一个有效的，通用的模拟程序。