GENETIC ANALYSIS WORKSHOP 15

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 每两年举行一次遗传分析研讨会(GAW)，国际知名的遗传流行病学家在会上分析真实和模拟的数据集，以演示新的遗传分析方法。2006年开始了分析工作，有两个真实数据集和一个模拟数据集。第一个真正的数据集包括有基因组扫描数据的14个3代CEPH犹他州家系(每个兄弟姐妹有8个后代，每个家庭大约有14个人)的3,554个基因的表达。第二个真正的数据集包括来自四个研究类风湿性关节炎遗传学的国际中心的家庭和病例对照数据。模拟数据集包括总计180万个同胞对的数据，是一个丰富的数据集，旨在模拟类风湿性关节炎，具有许多特殊功能，使数据分析师能够进行广泛的实验可能性。这次研讨会的论文现已发表。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Every two years a Genetic Analysis Workshop (GAW) is held at which internationally reputed genetic epidemiologists analyze real and simulated data sets in order to demonstrate new methods of genetic analysis. For 2006, on which analytical work was started, there were two real datasets and one simulated dataset. The first real dataset comprised the expression of 3,554 genes on 14 3-generation CEPH Utah families (s8 offspring per sibship, ~ 14 individuals per family) for which genome-scan data are available. The second real dataset comprised family and case-control data from four international centers studying the genetics of rheumatoid arthritis. The simulated dataset, comprising data on a total of 1.8 million sib-pairs, is a rich dataset designed to simulate rheumatoid arthritis with many special features to allow the data analyst a wide range of experimental possibilities. Papers from this workshop are now published.