DIFFUSION IN THE C ELEGANS GERM LINE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 线虫生殖系形成合胞体，使调节蛋白有可能从一个细胞扩散到另一个细胞。我们正在使用单点荧光相关光谱和成对相关来量化扩散特性。这些定量数据将被用来建立数学模型，解释生殖系干细胞如何做出自我更新或分化的决定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The C. elegans germ line forms a syncytium, making it possible for regulatory proteins to diffuse from one cell to another. We are quantifying diffusion properties using single-point fluorescent correlation spectroscopy and pair-correlation. Those quantitative data will be used to formulate mathematical models explaining how germline stem cells make a decision to self-renew or to differentiate.