THE ULTASTRUCTURAL LOCALIZATION OF MINERAL WITHIN THE COLLAGEN FIBRIL

胶原纤维内矿物质的超结构定位

• 批准号: 8169612
• 负责人: PAUL ARMS PRICE
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169612
• 关键词: Calcified; Collagen Fibril; Collagen Type I; Computer Retrieval of Information on Scientific Projects Database; Deposition; Funding; Grant; Incubated; Institution; Location; Minerals; Rattus; Research; Research Personnel; Resources; Serum; Source; Staging; Tendon structure; United States National Institutes of Health; Work; bone; in vivo; mineralization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously shown that tendon and demineralized bone re-calcify rapidly when incubated at 37C in rat serum (1). The objective of the present study is to examine the ultrastructural location of the initial mineral deposited into these type 1 collagen matrices during incubation in serum. Our working hypothesis is that the initial mineral will be deposited within the hole region of the collagen fibril, as has been seen in the initial stages of mineralization in vivo.

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