STOPPED FLOW TIME RESOLVED SAXS DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 时间分辨SAXS是BiOCAT提案中的主要核心项目之一。在前一报告期，我们的初步数据显示，Pilatus 100k像素阵列探测器是获取时间分辨SAXS数据的优越解决方案。在本报告所述期间，努力将我们自己的Pilatus探测器与新购置的停流仪进行系统集成，其标称死区时间为亚毫秒(0.45毫秒)。我们现在已经证实，使用我们为此购买的UV-VIS附件，它确实可以获得亚毫秒的分辨率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Time resolved SAXS is one of the major core projects in the BiOCAT proposal. In the previous reporting period we showed preliminary data that the Pilatus 100k pixel array detector was a superior solution for acquiring time-resolved SAXS data. In the current reporting period efforts were directed towards system integration of our own Pilatus detector with a newly acquired stopped-flow instrument with a nominal dead time of sub-ms (0.45ms). We now have verified that it can indeed obtain submillsecond time resolution with the UV-vis attachment that we bought for this purpose.