MIDWEST PROGENITOR CELL CONSORTIUM

中西部祖细胞联盟

• 批准号: 8173156
• 负责人: James Alexander Thomson
• 金额: $ 4.13万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173156
• 关键词: Cardiac; Cells; Cellular biology; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic Programming; Goals; Grant; Hematopoietic stem cells; Human; Institution; Minnesota; Research; Research Personnel; Resources; Somatic Cell; Source; Stem cells; United States National Institutes of Health; Universities; progenitor; programs; self-renewal; stem

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells. The Midwest Progenitor Cell Consortium is a collaboration between the UW-Madison and the University of Minnesota, which will serve as a research hub within the NHLBI's Progenitor Cell Biology Consortium. The goal is to develop new strategies to convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells through identification of genetic program leading to formation of pre-HSCs and cardiac progenitors and activation of self-renewal program in lineage restricted cells. Dr. Slukvin's involvement in the consortium relies on WNPRC Stem Cell Resources.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：将人多能干细胞和体细胞转化为造血干细胞(HSCs)和自我更新的心脏祖细胞。 中西部先祖细胞联盟是威斯康星大学麦迪逊分校和明尼苏达大学的合作项目，将成为NHLBI先祖细胞生物学联盟的研究中心。其目标是通过鉴定导致前造血干细胞和心脏祖细胞形成的遗传程序和激活谱系限制细胞中的自我更新程序，开发将人类多能干细胞和体细胞转化为造血干细胞和自我更新心脏前体细胞的新策略。 Slukvin博士在该财团的参与依赖于WNPRC干细胞资源。