MIDWEST PROGENITOR CELL CONSORTIUM

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：将人多能干细胞和体细胞转化为造血干细胞(HSCs)和自我更新的心脏祖细胞。 中西部先祖细胞联盟是威斯康星大学麦迪逊分校和明尼苏达大学的合作项目，将成为NHLBI先祖细胞生物学联盟的研究中心。其目标是通过鉴定导致前造血干细胞和心脏祖细胞形成的遗传程序和激活谱系限制细胞中的自我更新程序，开发将人类多能干细胞和体细胞转化为造血干细胞和自我更新心脏前体细胞的新策略。 该项目使用WNPRC干细胞资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells. The Midwest Progenitor Cell Consortium is a collaboration between the UW-Madison and the University of Minnesota, which will serve as a research hub within the NHLBI's Progenitor Cell Biology Consortium. The goal is to develop new strategies to convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells through identification of genetic program leading to formation of pre-HSCs and cardiac progenitors and activation of self-renewal program in lineage restricted cells. This project uses WNPRC Stem Cell Resources.