Northern Manhattan Initiative for Minority Involvement in Clinical Trials

描述（由申请人提供）：在临床研究中，特别是在临床试验中招募和保留少数民族人数不足，仍然是减少健康差距的一个重大障碍。虽然我们取得了成功，但我们认识到，很少有最佳做法准则系统地概述了促进和维持成功征聘和保留少数民族人口的成功战略。本申请是根据RFA-MD-11-005编写的。NIMHD资源相关少数民族健康和健康差异研究（U24）。该提案将特别关注“(a)生物伦理研究基础设施倡议”。我们的目标是整合和扩大现有资源，以完善和支持一个全面的多学科项目，以加强临床试验的招募和少数民族个体的保留。该项目将由欧文临床转化研究所社区参与核心资源（IICTR; UL1 RR024156）和北曼哈顿少数民族健康和健康差异卓越中心（NOCEMHD; P60 MD000206）之间的合作伙伴关系领导。NOCEMHD还包括北曼哈顿对比有效性研究卓越中心（CER）以消除差异（NOCERED; P60 MD000206PI-08S1）。CECR、NOCEMHD和NOCERED目前负责并支持招募少数族裔进行临床试验，是曼哈顿北部研究中招募少数族裔的核心资源。我们将这个提议的项目称为“北曼哈顿少数族裔参与临床试验倡议”（NIMICT）。NIMICT的具体目标是：1)开发、试点和评估一套“最佳实践”（工具和程序），以便在临床试验中成功招募和保留少数种族和族裔；2)拓展和细化

DESCRIPTION (provided by applicant): Poor recruitment and retention of minority populations in clinical research, and clinical trials in particular, continues to be a significant barrier in te reduction of health disparities. Although we have been successful we realize that there are few best-practice guidelines which have systematically outlined successful strategies to promote and sustain successful recruitment and retention of minority populations. This application was prepared in response to RFA-MD-11-005. NIMHD Resource-Related Minority Health and Health Disparities Research (U24). This proposal will specifically address focus "(a) Bioethics Research Infrastructure Initiative". Our goal is to integrate and expand existing resources to refine and support a comprehensive multidisciplinary program to enhance clinical trial recruitment and retention of minority individuals. This program will be lead by a partnership between the Community Engagement Core Resource ofthe Irving Institute for Clinical Translational Research (IICTR; UL1 RR024156) and the Northern Manhattan Center of Excellence in Minority Health and Health Disparities (NOCEMHD; P60 MD000206). NOCEMHD also includes the Northern Manhattan Center of Excellence for Comparative Effectiveness Research (CER) to Eliminate Disparities (NOCERED; P60 MD000206PI-08S1). The CECR, NOCEMHD, and NOCERED currently conduct and support recruitment of minorities for clinical trials, and are central resources for minority recruitment in research in Northern Manhattan. We will call this proposed program the Northern Manhattan Initiative for Minority involvement in Clinical Trials (NIMICT). The specific aims (SA) of NIMICT are: 1) Develop, pilot, and evaluate a toolkit of "Best Practices" (instruments and procedures) for the conduct of successful recruitment and retention of racial and ethnic minorities in clinical trials; 2) Expand and refine innovative recruitment strategies recently implemented at CUMC for general research for use in minority recruitment and retention in clinical trials, including a community health worker program and a health literacy program; 3) Building on the experience from SAs 1,2 and in collaboration with relevant stakeholders, NIMHD, and other national centers, disseminate the experience of our initiative and seek consensus to develop local and national guidelines for recruitment and retention of minorities in clinical trials. As part of the cooperative agreement, we expect significant collaboration with NIMHD and with other programs in the country with a similar focus. PUBLIC HEALTH RELEVANCE: RELEVANCE (See instructions): Poor recruitment and retention of minority populations in clinical research and clinical trials in particular continues o be significant barrier in the reduction of health disparities. Our goal is to develop and test tool, procedures and guidelines to improve minority recruitment and retention in clinical trials in collaboration with NIMHD and other national programs to be implemented locally and nationally.