Northern Manhattan Initiative for Minority Involvement in Clinical Trials

描述(由申请人提供)：在临床研究，特别是临床试验中，对少数群体的招募和留住不佳，仍然是缩小健康差距的一个重大障碍。尽管我们取得了成功，但我们认识到，很少有最佳做法准则系统地概述了促进和维持成功招募和留住少数群体的成功战略。本申请是根据RFA-MD-11-005编写的。NIMHD与资源相关的少数民族健康和健康差距研究(U24)。该提案将具体涉及重点“(A)生物伦理研究基础设施倡议”。我们的目标是整合和扩展现有资源，以完善和支持一个全面的多学科计划，以加强少数族裔个人的临床试验、招募和保留。该计划将由欧文临床转化研究所社区参与核心资源(IICTR；UL1 RR024156)和曼哈顿北部少数民族健康和健康差距卓越中心(NOCEMHD；P60 MD000206)之间的合作伙伴关系领导。NOCEMHD还包括曼哈顿北部比较有效性研究卓越中心(CER)，以消除差异(NOCERED；P60 MD000206PI-08S1)。CECR、NOCEMHD和NOCERED目前正在进行和支持招募少数族裔进行临床试验，并且是曼哈顿北部研究中招募少数族裔的核心资源。我们将把这项拟议的计划称为曼哈顿北部少数民族参与临床试验倡议(NIMICT)。NIMICT的具体目标(SA)是：1)开发、试验和评估“最佳做法”工具包(工具和程序)，以便在临床试验中成功招募和保留少数族裔；2)扩大和完善 最近在CUMC实施了创新的招募战略，用于临床试验中招募和保留少数族裔的一般研究，包括社区卫生工作者计划和健康素养计划；3)借鉴SAS 1，2的经验，并与相关利益攸关方、NIMHD和其他国家中心合作，传播我们倡议的经验，并寻求共识，以制定地方和国家关于在临床试验中招募和保留少数族裔的指导方针。作为合作协议的一部分，我们希望与NIMHD以及该国具有类似重点的其他项目进行重大合作。 与公共卫生的相关性：相关性(见说明)：在临床研究和临床试验中，特别是在临床研究和临床试验中，少数群体的招募和留存不力仍然是缩小健康差距的重大障碍。我们的目标是与NIMHD和其他国家项目合作，开发和测试工具、程序和指南，以改善临床试验中少数族裔的招募和保留，并在当地和全国范围内实施。

DESCRIPTION (provided by applicant): Poor recruitment and retention of minority populations in clinical research, and clinical trials in particular, continues to be a significant barrier in te reduction of health disparities. Although we have been successful we realize that there are few best-practice guidelines which have systematically outlined successful strategies to promote and sustain successful recruitment and retention of minority populations. This application was prepared in response to RFA-MD-11-005. NIMHD Resource-Related Minority Health and Health Disparities Research (U24). This proposal will specifically address focus "(a) Bioethics Research Infrastructure Initiative". Our goal is to integrate and expand existing resources to refine and support a comprehensive multidisciplinary program to enhance clinical trial recruitment and retention of minority individuals. This program will be lead by a partnership between the Community Engagement Core Resource ofthe Irving Institute for Clinical Translational Research (IICTR; UL1 RR024156) and the Northern Manhattan Center of Excellence in Minority Health and Health Disparities (NOCEMHD; P60 MD000206). NOCEMHD also includes the Northern Manhattan Center of Excellence for Comparative Effectiveness Research (CER) to Eliminate Disparities (NOCERED; P60 MD000206PI-08S1). The CECR, NOCEMHD, and NOCERED currently conduct and support recruitment of minorities for clinical trials, and are central resources for minority recruitment in research in Northern Manhattan. We will call this proposed program the Northern Manhattan Initiative for Minority involvement in Clinical Trials (NIMICT). The specific aims (SA) of NIMICT are: 1) Develop, pilot, and evaluate a toolkit of "Best Practices" (instruments and procedures) for the conduct of successful recruitment and retention of racial and ethnic minorities in clinical trials; 2) Expand and refine innovative recruitment strategies recently implemented at CUMC for general research for use in minority recruitment and retention in clinical trials, including a community health worker program and a health literacy program; 3) Building on the experience from SAs 1,2 and in collaboration with relevant stakeholders, NIMHD, and other national centers, disseminate the experience of our initiative and seek consensus to develop local and national guidelines for recruitment and retention of minorities in clinical trials. As part of the cooperative agreement, we expect significant collaboration with NIMHD and with other programs in the country with a similar focus. PUBLIC HEALTH RELEVANCE: RELEVANCE (See instructions): Poor recruitment and retention of minority populations in clinical research and clinical trials in particular continues o be significant barrier in the reduction of health disparities. Our goal is to develop and test tool, procedures and guidelines to improve minority recruitment and retention in clinical trials in collaboration with NIMHD and other national programs to be implemented locally and nationally.