UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations (UC END-DISPARITIES)

加州大学洛杉矶分校-UCI 消除多种族人群心脏代谢差异中心 (UC END-DISPARITIES)

• 批准号: 10494277
• 负责人: BERNADETTE Marie BODEN-ALBALA
• 金额: $ 350.24万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494277
• 关键词: Address; Affect; Aging; American Indians; Asian Pacific Islander; Atherosclerosis; Award; Biometry; Black race; California; Cardiometabolic Disease; Cardiovascular system; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical Research; Clinical Sciences; Communication; Communities; Community Health Systems; Complications of Diabetes Mellitus; County; Data Set; Development; Diabetes Mellitus; Disadvantaged; Discrimination; Disease Clusterings; Ethnic group; Evaluation; Family; Funding; Future; Goals; Health; Health Policy; Health system; Hypertension; Individual; Infrastructure; Institutes; Intervention; Latino; Link; Los Angeles; Low income; Measurement; Measures; Mentors; Mentorship; Methodology; Minority; Minority Groups; Minority Health Research; Minority-Serving Institution; Morbidity - disease rate; National Institute of General Medical Sciences; National Institute on Minority Health and Health Disparities; Oranges; Outcome; Outcome Measure; Outcomes Research; Pacific Island Americans; Participant; PhenX Toolkit; Pilot Projects; Population; Postdoctoral Fellow; Public Health; Reduce health disparities; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Risk Factors; Stress; Training; Training Programs; Translational Research; United States National Institutes of Health; Work; allostatic load; behavioral economics; cardiometabolic risk; cardiometabolism; care outcomes; career; catalyst; community engagement; data harmonization; data sharing; design; disease disparity; disorder prevention; flexibility; health disparity; health equity; health information technology; implementation science; improved; inflammatory marker; innovation; marginalized population; meetings; minority communities; mortality; multi-ethnic; patient population; premature; prevent; programs; social; social genomics; social health determinants; synergism; therapy design; tool; vulnerable community

Project Summary/Abstract P50 UC END-DISPARITIES UC END-DISPARITIES will address the inequitable multilevel factors that promote cardiometabolic disease, including hypertension, diabetes, and complications such as atherosclerotic vascular disease and chronic kidney disease. These conditions are highly influenced by structural disadvantage and disproportionately affect low-income, minoritized, and other marginalized groups in the highly diverse and contiguous region of Los Angeles County (LAC) and Orange County (OC) (combined population over 13M; > 46 states). The Center will fill a gap in the current efforts to advance health equity via a multilevel community-academic partnered approach to improve cardiometabolic related health outcomes in targeted LAC and OC Latino, Black, Asian, Pacific Islander, and American Indian communities, which have some of the highest rates of cardiometabolic risk factors and premature cardiovascular morbidity and mortality in the nation. UC END-DISPARITIES will function through three highly integrated cores and three inaugural center research projects across southern California, all supporting Pilot Awards and Community Catalyst Awards, while leveraging synergies with key community-academic networks, community, public health, and health system stakeholders, regional networks of minority-serving institutions, centers at UCLA and UCI for clinical and translational science, and methodologic leaders with expertise in health equity research, biostatistics, implementation science, and health information technology. The Administrative Core, Investigator Development Core, and Community Engagement Core will implement the following Center objectives: 1) Provide administrative and operational support for all activities and collaborate with the NIMHD Chronic Disease Disparities Coordinating Center; 2) Develop the requisite community-academic research infrastructure to improve the health of the diverse multiethnic communities of LAC and OC through multilevel interventions; 3) Broaden/enhance existing and new partnerships with communities to expand the pool of diverse participants in research and recipients of findings for UC END DISPARITIES and related funded entities; 4) Promote successful training and academic advancement of underrepresented post-doctoral and early career investigators through mentorship, opportunities to participate in community engaged health interventions, and support of pilot projects and subsequent independent cardiometabolic disparities research; 5) Conduct rigorous analyses and partner with community stakeholders to identify community, health system, family, and individual-level correlates of health disparities to inform research methods, health policy, and the design of community and health system partnered interventions to mitigate cardiometabolic disparities; and 6) Contribute to the development, evaluation, and dissemination of valid, reliable, and generalizable tools that can measure and track health outcomes and the social, behavioral, and economic predictors relevant to multiethnic communities at risk for cardiometabolic disease.

项目摘要/摘要 P50 UC终端-差异 UC End-Difference将解决促进心脏代谢性疾病的不公平多水平因素， 包括高血压、糖尿病以及动脉粥样硬化性血管疾病和慢性疾病等并发症 肾脏疾病。这些情况受结构性不利因素的影响很大，而且影响不成比例。 洛杉矶高度多样化和毗邻地区的低收入、小型化和其他边缘化群体 洛杉矶县(LAC)和橙县(OC)(总人口超过1300万；&GT；46个州)。该中心将 填补当前通过多层次社区-学术合作伙伴推进卫生公平的努力中的空白 改善目标LAC和OC的心脏代谢相关健康结局的方法拉美裔、黑人、亚洲人、 太平洋岛民和美洲印第安人社区，他们的心脏代谢率最高 风险因素和过早的心血管发病率和死亡率。统一通信终端差异将 通过三个高度集成的核心和三个首创中心研究项目发挥作用 南加州，所有支持飞行员奖和社区催化剂奖，同时利用 与关键的社区-学术网络、社区、公共卫生和卫生系统利益攸关方协同增效， 少数族裔服务机构的区域网络，加州大学洛杉矶分校和加州大学洛杉矶分校的临床和翻译中心 在卫生公平研究、生物统计学、实施方面具有专业知识的科学和方法论领导者 科学和卫生信息技术。行政核心、调查员开发核心和 社区参与核心将实施以下中心目标：1)提供管理 为所有活动提供业务支持，并与NIMHD慢性病差异中心合作 协调中心；2)开发必要的社区-学术研究基础设施，以改善 通过多层次的干预措施促进拉丁美洲和加勒比地区和奥委会不同多族裔社区的健康；3) 扩大/加强与社区的现有和新的伙伴关系，以扩大多样化的 UC End Difference和相关资助实体研究的参与者和结果接受者； 4)促进代表不足的博士后和早期研究人员的成功培训和学术进步 通过导师指导职业调查员，有机会参与社区参与的健康 对试点项目的干预和支持以及随后的心脏代谢独立差异 研究；5)进行严格的分析并与社区利益相关者合作，以确定社区， 卫生系统、家庭和个人层面的健康差距的相关性，以提供研究方法， 卫生政策，以及社区和卫生系统的设计配合干预措施，以减轻 心脏代谢的差异；以及6)有助于发展、评估和传播有效、 可靠的、可推广的工具，可以测量和跟踪健康结果以及社会、行为和 以及与心脏代谢性疾病风险的多民族社区相关的经济预测因素。