UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations (UC END-DISPARITIES)

加州大学洛杉矶分校-UCI 消除多种族人群心脏代谢差异中心 (UC END-DISPARITIES)

• 批准号: 10659227
• 负责人: BERNADETTE Marie BODEN-ALBALA
• 金额: $ 348.96万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659227
• 关键词: Acceleration; Affect; Aging; American Indians; Asian; Atherosclerosis; Award; Behavioral; Biometry; Black race; California; Cardiometabolic Disease; Cardiovascular system; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; County; Data Set; Development; Diabetes Mellitus; Disadvantaged; Discrimination; Disparity; Economics; Equity; Ethnic Population; Evaluation; Family; Funding; Future; Goals; Health; Health Policy; Health system; Hypertension; Individual; Inequity; Infrastructure; Institution; Intervention; Latino; Link; Los Angeles; Low income; Measurement; Measures; Mentors; Mentorship; Methodology; Minority; Minority Groups; Minority Health Research; Minority-Serving Institution; Morbidity - disease rate; National Institute of General Medical Sciences; National Institute on Minority Health and Health Disparities; Oranges; Outcome; Outcomes Research; Pacific Islander; Participant; PhenX Toolkit; Pilot Projects; Population; Postdoctoral Fellow; Public Health; Reduce health disparities; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Risk Factors; Stress; Training; Training Programs; Translational Research; United States National Institutes of Health; Work; allostatic load; cardiometabolic risk; cardiometabolism; care outcomes; career; catalyst; community engagement; data harmonization; data sharing; design; disease disparity; disorder prevention; flexibility; health disparity; health equity; health information technology; implementation science; improved; inflammatory marker; innovation; marginalized population; meetings; minority communities; mortality; multi-ethnic; patient population; premature; prevent; programs; social; social genomics; social health determinants; structural determinants; synergism; therapy design; tool; vulnerable community

Project Summary/Abstract P50 UC END-DISPARITIES UC END-DISPARITIES will address the inequitable multilevel factors that promote cardiometabolic disease, including hypertension, diabetes, and complications such as atherosclerotic vascular disease and chronic kidney disease. These conditions are highly influenced by structural disadvantage and disproportionately affect low-income, minoritized, and other marginalized groups in the highly diverse and contiguous region of Los Angeles County (LAC) and Orange County (OC) (combined population over 13M; > 46 states). The Center will fill a gap in the current efforts to advance health equity via a multilevel community-academic partnered approach to improve cardiometabolic related health outcomes in targeted LAC and OC Latino, Black, Asian, Pacific Islander, and American Indian communities, which have some of the highest rates of cardiometabolic risk factors and premature cardiovascular morbidity and mortality in the nation. UC END-DISPARITIES will function through three highly integrated cores and three inaugural center research projects across southern California, all supporting Pilot Awards and Community Catalyst Awards, while leveraging synergies with key community-academic networks, community, public health, and health system stakeholders, regional networks of minority-serving institutions, centers at UCLA and UCI for clinical and translational science, and methodologic leaders with expertise in health equity research, biostatistics, implementation science, and health information technology. The Administrative Core, Investigator Development Core, and Community Engagement Core will implement the following Center objectives: 1) Provide administrative and operational support for all activities and collaborate with the NIMHD Chronic Disease Disparities Coordinating Center; 2) Develop the requisite community-academic research infrastructure to improve the health of the diverse multiethnic communities of LAC and OC through multilevel interventions; 3) Broaden/enhance existing and new partnerships with communities to expand the pool of diverse participants in research and recipients of findings for UC END DISPARITIES and related funded entities; 4) Promote successful training and academic advancement of underrepresented post-doctoral and early career investigators through mentorship, opportunities to participate in community engaged health interventions, and support of pilot projects and subsequent independent cardiometabolic disparities research; 5) Conduct rigorous analyses and partner with community stakeholders to identify community, health system, family, and individual-level correlates of health disparities to inform research methods, health policy, and the design of community and health system partnered interventions to mitigate cardiometabolic disparities; and 6) Contribute to the development, evaluation, and dissemination of valid, reliable, and generalizable tools that can measure and track health outcomes and the social, behavioral, and economic predictors relevant to multiethnic communities at risk for cardiometabolic disease.

项目总结/摘要 P50 UC末端差异 UC末端差异将解决促进心脏代谢疾病的不公平多层次因素， 包括高血压、糖尿病和并发症，如动脉粥样硬化性血管疾病和慢性 肾病这些条件受到结构性不利因素的严重影响， 低收入，少数民族，和其他边缘化群体在高度多样化和毗邻地区的洛杉矶 洛杉矶县（LAC）和橙子县（OC）（总人口超过1300万;超过46个州）。该中心将 通过多层次的社区-学术合作，填补目前推进卫生公平努力的空白 改善目标LAC和OC拉丁裔、黑人、亚裔 太平洋岛民和美洲印第安人社区，这些社区的心脏代谢率最高， 危险因素和过早心血管发病率和死亡率在全国。UC结束差异将 通过三个高度集成的核心和三个开创性的中心研究项目， 南加州，所有支持试点奖和社区催化剂奖，同时利用 与主要社区学术网络、社区、公共卫生和卫生系统利益攸关方的协同作用， 少数民族服务机构的区域网络，加州大学洛杉矶分校和加州大学CI的临床和翻译中心 在健康公平研究、生物统计、实施方面具有专业知识的科学和方法学领导者 科学和卫生信息技术。管理核心、研究者发展核心和 社区参与核心将实现以下中心目标：1）提供行政管理 为所有活动提供业务支持，并与NIMHD慢性病差异合作 协调中心; 2）发展必要的社区-学术研究基础设施，以改善 通过多层次干预措施，改善拉丁美洲和加勒比地区和大洋洲不同多族裔社区的健康状况; 3） 扩大/加强与社区的现有和新的伙伴关系， 研究参与者和UC END DISPARITIES和相关资助实体的研究结果接受者; 4)促进代表性不足的博士后和早期研究生的成功培训和学术进步 职业调查员通过指导，机会参与社区参与健康 干预措施和支持试点项目以及随后的独立心脏代谢差异 研究; 5）进行严格的分析，并与社区利益相关者合作，以确定社区， 卫生系统、家庭和个人层面的健康差异相关性为研究方法提供信息， 卫生政策，以及社区和卫生系统合作干预措施的设计， 心脏代谢差异; 6）促进有效的， 可靠的，可推广的工具，可以测量和跟踪健康结果和社会，行为， 以及与多种族社区心脏代谢疾病风险相关的经济预测因素。

项目成果

Economic Modeling Analysis of an Intensive GDMT Optimization Program in Hospitalized Heart Failure Patients.

住院心力衰竭患者强化 GDMT 优化计划的经济模型分析。

• DOI: 10.1161/circheartfailure.123.011218
• 发表时间: 2023
• 期刊: Circulation. Heart failure
• 作者: Dixit,NealM;Parikh,NeilU;Ziaeian,Boback;Fonarow,GreggC
• 通讯作者: Fonarow,GreggC

Effects of System-Level Factors on Race/Ethnic Differences in In-Hospital Mortality after Acute Ischemic Stroke.

系统级因素对急性缺血性中风后院内死亡率种族/民族差异的影响。

• DOI: 10.1101/2023.10.20.23297343
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Sun,Philip;Markovic,Daniela;Ibish,Abdullah;Faigle,Roland;Gottesman,Rebecca;Towfighi,Amytis
• 通讯作者: Towfighi,Amytis

Cardiovascular Disease's Lonely Hearts Club.

心血管疾病的孤独之心俱乐部。

• DOI: 10.1016/j.amjcard.2023.11.015
• 发表时间: 2024
• 期刊: The American journal of cardiology
• 作者: Agarwal,ManyooA;Ziaeian,Boback
• 通讯作者: Ziaeian,Boback