Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders

有自闭症谱系障碍风险的儿童的自我调节和睡眠

• 批准号: 8028734
• 负责人: AMY J SCHWICHTENBERG
• 金额: $ 9万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8028734
• 关键词: Adopted; Affect; Age; Age-Months; Anger; Area; Attention; Autistic Disorder; Award; Behavior; Behavior Control; Behavior assessment; Behavioral; California; Child; Clinical; Clinical assessments; Code; Cognition; Cross-Sectional Studies; DSM-IV; Data; Data Analyses; Development; Developmental Disabilities; Developmental Process; Emotional; Emotions; Exhibits; Eye; Family; Family Study; Fright; Frustration; Future; Gays; Goals; Guidelines; Home environment; Human Development; Infant; Informal Social Control; Institutes; Investigation; Knowledge; Laboratories; Language; Language Delays; Leadership; Learning; Life; Longitudinal Studies; Measures; Medical; Methods; Modeling; Neurodevelopmental Disorder; Outcome; Parenting behavior; Parents; Participant; Phase; Phenotype; Physiological; Positioning Attribute; Procedures; Psychology; Publishing; Relative (related person); Reporting; Research; Research Personnel; Risk; Role; Screening procedure; Secure; Siblings; Sleep; Sleep Disorders; Structure; Techniques; Testing; Time; TimeLine; Training; Universities; actigraphy; autism spectrum disorder; base; career; design; experience; high risk; high risk infant; improved; longitudinal design; prospective; skills; social; social communication; success; ward

DESCRIPTION (provided by applicant): The overarching goals of this research are to better understand the development of self-regulation in young children at risk for Autism Spectrum Disorders (ASD) and to elucidate the longitudinal associations between self-regulation and sleep in these children. It is critically important to study the infant siblings of children with ASD because they are at risk not only for ASD, but also for numerous negative developmental outcomes including difficulties in language, social-emotional functioning, attention, behavior and cognition. Previous studies of infant siblings at risk for ASD have focused mainly on the three core deficit areas of communication, social, and restricted/repetitive behavior, but recent research and preliminary data suggest that difficulties of this group extend more broadly to difficulties with self-regulation. Specifically, problems with attention, behavior and negative emotion control appear elevated in infant siblings of children with ASD. Difficulties in these areas are robustly associated with sleep. Children with sleep problems have more difficulties with attention and behavior control and exhibit more negative affect and emotional reactivity. Additional research on siblings of children with ASD is needed to elucidate their adverse developmental outcomes and the proposed studies aim to do this within the domains of self-regulation and sleep. Two studies are proposed to examine self-regulation and sleep problems and the dynamic developmental progression between them in two groups of children: infant siblings of children with ASD (high risk) and infant siblings of typically developing children (low risk). The first is a cross-sectional study examining the rates of self-regulation and sleep problems in high risk infant siblings at 24 and 36 months of age. The second is a prospective longitudinal study that assesses children at 18, 24, and 30 months of age to examine the developmental progression and associations between self-regulation and sleep. Within each study self-regulation and sleep will be assessed with behavioral, physiological, and parent-report measures. The ultimate significance of this line of research is to improve the developmental trajectories and family life of children at risk for ASD by drawing attention to often unconsidered areas of development: self-regulation and sleep. Understanding the rates of sleep problems and the roles of sleep in self-regulation has the potential to inform assessment, treatment and parenting guidelines. Dr. Schwichtenberg is an ideal candidate for the proposed studies with her educational and research experience in self-regulation and sleep development. She has specialized training in the physiological assessment of sleep and two behavioral self-regulation paradigms. Her knowledge of sleep and self- regulation includes assessment procedures, coding, screening, and analyzing and she has published in both areas. Dr. Schwichtenberg also has experience on two prospective longitudinal studies of children developing at risk, making her keenly aware of the real life considerations needed to complete such a study. With the training proposed in this application she will secure the final clinical, methodological, statistical, and lab management skills needed to transition from a postdoctoral scholar to an independent researcher with a unique line of research in the developmental processes of self-regulation and sleep in children developing at risk. Dr. Schwichtenberg's career goals are to obtain a tenure-track position in a department of Psychology or Human Development at a university with an established developmental disabilities center and to launch a research lab that studies a variety of self-regulatory capacities in young children with and at risk for developmental disabilities. Dr. Schwichtenberg's training plan will be carried out at one of the foremost centers for excellence in developmental disabilities, the University of California - Davis, M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders). Her training includes advancing her skills in clinical assessment, learning a specialized non-invasive sleep assessment technique (videosomnography), securing advanced statistical training in longitudinal data analysis, learning eye-tracking assessment and coding methods, and completing structured training in laboratory management and leadership. Her sponsors Dr. Sally Ozonoff and Dr. Thomas Anders are two internationally recognized scholars in the areas of autism and sleep and are dedicated to her training and future success. PUBLIC HEALTH RELEVANCE: The goals of this research are to better understand the range of difficulties that younger siblings of children with autism experience. Previous research has documented that they are at increased risk for autism and language delays but recently emerging data suggest that they are at risk for several other difficulties, including self-regulatory problems (e.g., poor control of behavior, attention, and emotion) and sleep problems. This application aims to better understand the development of self-regulation and sleep in young children at risk for autism, thereby improving their development and family life and informing assessment, treatment and parenting guidelines.

描述（由申请人提供）：这项研究的总体目标是更好地了解患有自闭症谱系障碍风险的幼儿的自我调节（ASD），并阐明这些孩子的自我调节与睡眠之间的纵向关联。研究ASD儿童的婴儿兄弟姐妹至关重要，因为他们不仅面临ASD的危险，而且要面临许多负面发展结果，包括语言困难，社会情感功能，注意力，行为和认知。先前对有ASD风险的婴儿兄弟姐妹的研究主要集中在沟通，社会和有限/重复性行为的三个核心赤字领域，但是最近的研究和初步数据表明，该组的困难更广泛地扩展到自我调节方面的困难。具体而言，注意力ASD儿童的婴儿兄弟姐妹的注意力，行为和负面情绪控制的问题似乎升高。这些领域的困难与睡眠有牢固的联系。患有睡眠问题的儿童在注意力和行为控制方面有更多困难，并且表现出更多的负面影响和情绪反应性。需要对患有ASD儿童的兄弟姐妹的进一步研究来阐明他们的不良发育结果，而拟议的研究旨在在自我调节和睡眠领域内进行此操作。提出了两项​​研究，以检查两组儿童的自我调节和睡眠问题以及他们之间的动态发展进展：ASD儿童的婴儿兄弟姐妹（高风险）（高风险）和典型患儿童的婴儿兄弟姐妹（低风险）。首先是一项横断面研究，研究了24个月和36个月大的高风险婴儿兄弟姐妹的自我调节和睡眠问题的率。第二个是一项前瞻性纵向研究，该研究评估了18、24和30个月大的儿童，以检查自我调节与睡眠之间的发育进展和关联。在每个研究中，将通过行为，生理和父母报告措施评估自我调节和睡眠。这一研究线的最终意义是通过引起人们对经常未经考虑的发展领域的注意：自我调节和睡眠，改善有ASD风险的儿童的发展轨迹和家庭生活。了解睡眠问题的速度和睡眠在自我调节中的作用有可能为评估，治疗和育儿指南提供信息。 Schwichtenberg博士是她在自我调节和睡眠发展方面的教育和研究经验的理想候选人。她在睡眠生理评估和两个行为自我调节范例方面进行了专门的培训。她对睡眠和自我调节的了解包括评估程序，编码，筛查和分析，她在这两个领域都发表了。 Schwichtenberg博士还拥有两项前瞻性纵向研究的经验。通过在本申请中提出的培训，她将确保从博士后学者过渡到独立的研究人员所需的最终临床，方法论，统计和实验室管理技能，并具有独特的研究方面的自我调节和睡眠过程中的独特研究。 Schwichtenberg博士的职业目标是在具有既定的发育障碍中心的大学的心理学或人类发展系中获得终身任职地位，并启动研究实验室，研究具有发育障碍风险和有发育障碍风险的幼儿的各种自我调节能力。 Schwichtenberg博士的培训计划将在加利福尼亚大学 - 戴维斯大学，M.I.N.D.的最重要的发育障碍中心之一。研究所（神经发育障碍的医学调查）。她的培训包括在临床评估方面提高她的技能，学习一种专业的非侵入性睡眠评估技术（视频记录），在纵向数据分析中确保高级统计培训，学习眼神跟踪评估和编码方法，并在实验室管理和领导力中完成结构化培训。她的赞助商Sally Ozonoff博士和Thomas Anders博士是自闭症和睡眠领域的两名国际认可的学者，并致力于她的培训和未来的成功。 公共卫生相关性：这项研究的目标是更好地了解具有自闭症经验的儿童年轻兄弟姐妹的困难范围。先前的研究表明，它们对自闭症和语言延迟的风险增加，但最近新兴的数据表明，它们面临其他一些困难的风险，包括自我调节问题（例如，对行为，注意力和情绪的控制不佳）和睡眠问题。该应用程序旨在更好地了解有自闭症风险的幼儿的自我调节和睡眠的发展，从而改善了他们的发展和家庭生活，并为评估，治疗和育儿指南提供了信息。