Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders

有自闭症谱系障碍风险的儿童的自我调节和睡眠

• 批准号: 8820933
• 负责人: AMY J SCHWICHTENBERG
• 金额: $ 24万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-22 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8820933
• 关键词: Adopted; Affect; Age; Age-Months; Anger; Area; Attention; Autistic Disorder; Award; Behavior; Behavior Control; Behavior assessment; Behavioral; California; Child; Child Rearing; Clinical; Clinical assessments; Code; Cognition; Cross-Sectional Studies; DSM-IV; Data; Data Analyses; Development; Developmental Disabilities; Developmental Process; Emotional; Emotions; Exhibits; Eye; Family; Family Study; Fright; Frustration; Future; Gays; Goals; Guidelines; Home environment; Human Development; Infant; Informal Social Control; Institutes; Investigation; Knowledge; Laboratories; Language; Language Delays; Leadership; Learning; Life; Longitudinal Studies; Measures; Medical; Methods; Neurodevelopmental Disorder; Outcome; Parents; Participant; Phase; Phenotype; Physiological; Positioning Attribute; Procedures; Psychology; Publishing; Relative (related person); Reporting; Research; Research Personnel; Risk; Role; Secure; Siblings; Sleep; Sleep Disorders; Structure; Techniques; Testing; Time; TimeLine; Training; Universities; actigraphy; autism spectrum disorder; base; career; causal model; design; experience; high risk; high risk infant; improved; longitudinal design; prospective; screening; skills; social; social communication; success; sustained attention; ward

Project Summary The overarching goals of this research are to better understand the development of self-regulation in young children at risk for Autism Spectrum Disorders (ASD) and to elucidate the longitudinal associations between self-regulation and sleep in these children. It is critically important to study the infant siblings of children with ASD because they are at risk not only for ASD, but also for numerous negative developmental outcomes including difficulties in language, social-emotional functioning, attention, behavior and cognition. Previous studies of infant siblings at risk for ASD have focused mainly on the three core deficit areas of communication, social, and restricted/repetitive behavior, but recent research and preliminary data suggest that difficulties of this group extend more broadly to difficulties with self-regulation. Specifically, problems with attention, behavior and negative emotion control appear elevated in infant siblings of children with ASD. Difficulties in these areas are robustly associated with sleep. Children with sleep problems have more difficulties with attention and behavior control and exhibit more negative affect and emotional reactivity. Additional research on siblings of children with ASD is needed to elucidate their adverse developmental outcomes and the proposed studies aim to do this within the domains of self-regulation and sleep. Two studies are proposed to examine self-regulation and sleep problems and the dynamic developmental progression between them in two groups of children: infant siblings of children with ASD (high risk) and infant siblings of typically developing children (low risk). The first is a cross-sectional study examining the rates of self-regulation and sleep problems in high risk infant siblings at 24 and 36 months of age. The second is a prospective longitudinal study that assesses children at 18, 24, and 30 months of age to examine the developmental progression and associations between self-regulation and sleep. Within each study self-regulation and sleep will be assessed with behavioral, physiological, and parent-report measures. The ultimate significance of this line of research is to improve the developmental trajectories and family life of children at risk for ASD by drawing attention to often unconsidered areas of development: self-regulation and sleep. Understanding the rates of sleep problems and the roles of sleep in self-regulation has the potential to inform assessment, treatment and parenting guidelines. Dr. Schwichtenberg is an ideal candidate for the proposed studies with her educational and research experience in self-regulation and sleep development. She has specialized training in the physiological assessment of sleep and two behavioral self-regulation paradigms. Her knowledge of sleep and self- regulation includes assessment procedures, coding, screening, and analyzing and she has published in both areas. Dr. Schwichtenberg also has experience on two prospective longitudinal studies of children developing at risk, making her keenly aware of the real life considerations needed to complete such a study. With the training proposed in this application she will secure the final clinical, methodological, statistical, and lab management skills needed to transition from a postdoctoral scholar to an independent researcher with a unique line of research in the developmental processes of self-regulation and sleep in children developing at risk. Dr. Schwichtenberg's career goals are to obtain a tenure-track position in a department of Psychology or Human Development at a university with an established developmental disabilities center and to launch a research lab that studies a variety of self-regulatory capacities in young children with and at risk for developmental disabilities. Dr. Schwichtenberg's training plan will be carried out at one of the foremost centers for excellence in developmental disabilities, the University of California - Davis, M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders). Her training includes advancing her skills in clinical assessment, learning a specialized non-invasive sleep assessment technique (videosomnography), securing advanced statistical training in longitudinal data analysis, learning eye-tracking assessment and coding methods, and completing structured training in laboratory management and leadership. Her sponsors Dr. Sally Ozonoff and Dr. Thomas Anders are two internationally recognized scholars in the areas of autism and sleep and are dedicated to her training and future success.

项目摘要 这项研究的主要目标是更好地了解自我调节的发展 儿童患自闭症谱系障碍(ASD)的风险及其纵向关联 在这些孩子的自我调节和睡眠之间。研究婴儿的兄弟姐妹是至关重要的。 儿童患有自闭症，因为他们不仅有患自闭症的风险，而且还有许多发育不良的风险 结果包括语言、社会情绪功能、注意力、行为和认知方面的困难。 以前对有ASD风险的婴儿兄弟姐妹的研究主要集中在以下三个核心缺陷领域 沟通、社交和限制/重复行为，但最近的研究和初步数据表明 这一群体的困难更广泛地延伸到自律方面的困难。具体地说，问题 在注意力集中的情况下，行为和消极情绪控制在儿童的婴儿兄弟姐妹中表现得更高 ASD.这些方面的困难与睡眠密切相关。有睡眠问题的儿童有更多 注意力和行为控制困难，表现出更多的负面情绪和情绪反应。 需要对自闭症儿童的兄弟姐妹进行更多的研究来阐明他们的不利发育 结果和拟议的研究的目的是在自我调节和睡眠领域做到这一点。二 研究的目的是考察自我调节和睡眠问题以及动态发展 在两组儿童中它们之间的进展：ASD儿童的婴儿兄弟姐妹(高危)和 典型发育中儿童的婴儿兄弟姐妹(低风险)。第一项是一项横断面研究，考察了 24个月和36个月大的高危婴儿兄弟姐妹的自我调节和睡眠问题的比率。这个 第二项是前瞻性的纵向研究，评估18、24和30个月大的儿童 研究发育过程以及自我调节和睡眠之间的关系。在每个 学习自我调节和睡眠将通过行为、生理和父母报告措施进行评估。 这条研究路线的最终意义是改善儿童的发展轨迹和家庭生活 通过提请人们注意往往未考虑到的发展领域：自我调节，从而降低儿童患自闭症的风险 然后睡觉。了解睡眠问题的发生率和睡眠在自我调节中的作用 有可能为评估、治疗和育儿指南提供信息。 施维滕贝格博士凭借她的教育和研究，是拟议研究的理想人选 有自我调节和睡眠发展的经验。她受过专门的生理学训练。 睡眠评估和两种行为自我调节范式。她对睡眠和自我的了解 法规包括评估程序、编码、筛选和分析，她已在 两个地区都有。施维滕贝格博士还拥有两项儿童前瞻性纵向研究的经验。 在风险中发展，使她敏锐地意识到完成这样一项研究所需的现实生活考虑。 通过本申请中建议的培训，她将确保最终的临床、方法学、统计学和 从博士后学者过渡到独立研究员需要的实验室管理技能 儿童发育中自我调节和睡眠发展过程的独特研究 处于危险之中。施维滕贝格博士的职业目标是在以下部门获得终身教职 心理学或人类发展在已建立发育障碍中心的大学 并建立一个研究实验室，研究幼儿的各种自我调节能力。 发育障碍的风险。 Schwichtenberg博士的培训计划将在全球最重要的卓越中心之一进行 发展性残疾，加州大学戴维斯分校，M.I.N.D.研究所(医学调查 神经发育障碍)。她的训练包括提高她的临床评估技能，学习 专门的非侵入性睡眠评估技术(视频睡眠图)，确保高级统计 接受纵向数据分析培训，学习眼球跟踪评估和编码方法，以及 完成实验室管理和领导力方面的系统培训。她的赞助商萨利·奥佐诺夫博士 托马斯·安德斯博士是自闭症和睡眠领域的两位国际公认的学者， 都致力于她的训练和未来的成功。