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Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders

有自闭症谱系障碍风险的儿童的自我调节和睡眠

基本信息

批准号：
8204719
负责人：
AMY J SCHWICHTENBERG
金额：
$ 8.79万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8204719
关键词：
Adopted Affect Age Age-Months Anger Area Attention Autistic Disorder Award Behavior Behavior Control Behavior assessment Behavioral California Child Clinical Clinical assessments Code Cognition Cross-Sectional Studies DSM-IV Data Data Analyses Development Developmental Disabilities Developmental Process Emotional Emotions Exhibits Eye Family Family Study Fright Frustration Future Gays Goals Guidelines Home environment Human Development Infant Informal Social Control Institutes Investigation Knowledge Laboratories Language Language Delays Leadership Learning Life Longitudinal Studies Measures Medical Methods Modeling Neurodevelopmental Disorder Outcome Parenting behavior Parents Participant Phase Phenotype Physiological Positioning Attribute Procedures Psychology Publishing Relative (related person)Reporting Research Research Personnel Risk Role Screening procedure Secure Siblings Sleep Sleep Disorders Structure Techniques Testing Time TimeLine Training Universities actigraphy autism spectrum disorder base career design experience high risk high risk infant improved longitudinal design prospective skills social social communication success ward

项目摘要

DESCRIPTION (provided by applicant): The overarching goals of this research are to better understand the development of self-regulation in young children at risk for Autism Spectrum Disorders (ASD) and to elucidate the longitudinal associations between self-regulation and sleep in these children. It is critically important to study the infant siblings of children with ASD because they are at risk not only for ASD, but also for numerous negative developmental outcomes including difficulties in language, social-emotional functioning, attention, behavior and cognition. Previous studies of infant siblings at risk for ASD have focused mainly on the three core deficit areas of communication, social, and restricted/repetitive behavior, but recent research and preliminary data suggest that difficulties of this group extend more broadly to difficulties with self-regulation. Specifically, problems with attention, behavior and negative emotion control appear elevated in infant siblings of children with ASD. Difficulties in these areas are robustly associated with sleep. Children with sleep problems have more difficulties with attention and behavior control and exhibit more negative affect and emotional reactivity. Additional research on siblings of children with ASD is needed to elucidate their adverse developmental outcomes and the proposed studies aim to do this within the domains of self-regulation and sleep. Two studies are proposed to examine self-regulation and sleep problems and the dynamic developmental progression between them in two groups of children: infant siblings of children with ASD (high risk) and infant siblings of typically developing children (low risk). The first is a cross-sectional study examining the rates of self-regulation and sleep problems in high risk infant siblings at 24 and 36 months of age. The second is a prospective longitudinal study that assesses children at 18, 24, and 30 months of age to examine the developmental progression and associations between self-regulation and sleep. Within each study self-regulation and sleep will be assessed with behavioral, physiological, and parent-report measures. The ultimate significance of this line of research is to improve the developmental trajectories and family life of children at risk for ASD by drawing attention to often unconsidered areas of development: self-regulation and sleep. Understanding the rates of sleep problems and the roles of sleep in self-regulation has the potential to inform assessment, treatment and parenting guidelines. Dr. Schwichtenberg is an ideal candidate for the proposed studies with her educational and research experience in self-regulation and sleep development. She has specialized training in the physiological assessment of sleep and two behavioral self-regulation paradigms. Her knowledge of sleep and self- regulation includes assessment procedures, coding, screening, and analyzing and she has published in both areas. Dr. Schwichtenberg also has experience on two prospective longitudinal studies of children developing at risk, making her keenly aware of the real life considerations needed to complete such a study. With the training proposed in this application she will secure the final clinical, methodological, statistical, and lab management skills needed to transition from a postdoctoral scholar to an independent researcher with a unique line of research in the developmental processes of self-regulation and sleep in children developing at risk. Dr. Schwichtenberg's career goals are to obtain a tenure-track position in a department of Psychology or Human Development at a university with an established developmental disabilities center and to launch a research lab that studies a variety of self-regulatory capacities in young children with and at risk for developmental disabilities. Dr. Schwichtenberg's training plan will be carried out at one of the foremost centers for excellence in developmental disabilities, the University of California - Davis, M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders). Her training includes advancing her skills in clinical assessment, learning a specialized non-invasive sleep assessment technique (videosomnography), securing advanced statistical training in longitudinal data analysis, learning eye-tracking assessment and coding methods, and completing structured training in laboratory management and leadership. Her sponsors Dr. Sally Ozonoff and Dr. Thomas Anders are two internationally recognized scholars in the areas of autism and sleep and are dedicated to her training and future success.

描述（由申请人提供）：本研究的总体目标是更好地了解自闭症谱系障碍（ASD）风险幼儿自我调节的发展，并阐明这些儿童自我调节和睡眠之间的纵向关联。研究ASD儿童的婴儿兄弟姐妹至关重要，因为他们不仅有ASD的风险，而且还有许多负面的发展结果，包括语言，社会情感功能，注意力，行为和认知方面的困难。以前的研究主要集中在沟通，社会和限制/重复行为的三个核心缺陷领域，但最近的研究和初步数据表明，这个群体的困难更广泛地扩展到自我调节的困难。具体来说，注意力、行为和负面情绪控制的问题在ASD儿童的婴儿兄弟姐妹中出现升高。这些领域的困难与睡眠密切相关。有睡眠问题的儿童在注意力和行为控制方面有更多的困难，表现出更多的负面影响和情绪反应。需要对ASD儿童的兄弟姐妹进行额外的研究，以阐明他们的不良发展结果，拟议的研究旨在自我调节和睡眠领域内进行研究。提出了两项研究，以检查自我调节和睡眠问题，以及它们之间的动态发展进展，在两组儿童：婴儿兄弟姐妹的儿童ASD（高风险）和婴儿兄弟姐妹的典型发展的儿童（低风险）。第一个是一个横断面研究，检查24个月和36个月大的高风险婴儿兄弟姐妹的自我调节和睡眠问题的比率。第二项是前瞻性纵向研究，评估18个月、24个月和30个月大的儿童，以检查自我调节和睡眠之间的发展进展和关联。在每项研究中，自我调节和睡眠将通过行为，生理和父母报告的措施进行评估。这项研究的最终意义是通过关注经常被忽视的发展领域来改善ASD风险儿童的发展轨迹和家庭生活：自我调节和睡眠。了解睡眠问题的发生率以及睡眠在自我调节中的作用，有可能为评估、治疗和育儿指南提供信息。Schwichtenberg博士是拟议研究的理想候选人，她在自我调节和睡眠发展方面的教育和研究经验。她在睡眠的生理评估和两种行为自我调节范式方面接受过专门培训。她的睡眠和自我调节的知识包括评估程序，编码，筛选和分析，她已经在这两个领域发表。Schwichtenberg博士还拥有两项关于处于风险中的儿童的前瞻性纵向研究的经验，使她敏锐地意识到完成这样一项研究所需的真实的生活考虑。通过本申请中提出的培训，她将获得从博士后学者过渡到独立研究人员所需的最终临床，方法，统计和实验室管理技能，该研究人员在自我调节和睡眠的发展过程中具有独特的研究路线儿童发展风险。Schwichtenberg博士的职业目标是在一所拥有发育障碍中心的大学的心理学或人类发展系获得终身职位，并建立一个研究实验室，研究患有发育障碍和有发育障碍风险的幼儿的各种自我调节能力。Schwichtenberg博士的培训计划将在加州大学戴维斯分校（University of California - Davis，M.I.N.D.）进行，该中心是发育障碍领域最重要的卓越中心之一。神经发育障碍医学研究所（Medical Investigation of Neurodevelopmental Disorders）她的培训包括提高她在临床评估方面的技能，学习专门的非侵入性睡眠评估技术（视频睡眠图），确保纵向数据分析的高级统计培训，学习眼动跟踪评估和编码方法，并完成实验室管理和领导力的结构化培训。她的赞助商Sally Ozonoff博士和托马斯安德斯博士是自闭症和睡眠领域的两位国际知名学者，致力于她的培训和未来的成功。