Self-Regulation and Sleep in Children At Risk for Autism Spectrum Disorders

有自闭症谱系障碍风险的儿童的自我调节和睡眠

• 批准号: 8624766
• 负责人: AMY J SCHWICHTENBERG
• 金额: $ 24.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-22 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8624766
• 关键词: Adopted; Affect; Age; Age-Months; Anger; Area; Attention; Autistic Disorder; Award; Behavior; Behavior Control; Behavior assessment; Behavioral; California; Child; Clinical; Clinical assessments; Code; Cognition; Cross-Sectional Studies; DSM-IV; Data; Data Analyses; Development; Developmental Disabilities; Developmental Process; Emotional; Emotions; Exhibits; Eye; Family; Family Study; Fright; Frustration; Future; Gays; Goals; Guidelines; Home environment; Human Development; Infant; Informal Social Control; Institutes; Investigation; Knowledge; Laboratories; Language; Language Delays; Leadership; Learning; Life; Longitudinal Studies; Measures; Medical; Methods; Modeling; Neurodevelopmental Disorder; Outcome; Parenting behavior; Parents; Participant; Phase; Phenotype; Physiological; Positioning Attribute; Procedures; Psychology; Publishing; Relative (related person); Reporting; Research; Research Personnel; Risk; Role; Secure; Siblings; Sleep; Sleep Disorders; Structure; Techniques; Testing; Time; TimeLine; Training; Universities; actigraphy; autism spectrum disorder; base; career; design; experience; high risk; high risk infant; improved; longitudinal design; prospective; screening; skills; social; social communication; success; ward

Project Summary The overarching goals of this research are to better understand the development of self-regulation in young children at risk for Autism Spectrum Disorders (ASD) and to elucidate the longitudinal associations between self-regulation and sleep in these children. It is critically important to study the infant siblings of children with ASD because they are at risk not only for ASD, but also for numerous negative developmental outcomes including difficulties in language, social-emotional functioning, attention, behavior and cognition. Previous studies of infant siblings at risk for ASD have focused mainly on the three core deficit areas of communication, social, and restricted/repetitive behavior, but recent research and preliminary data suggest that difficulties of this group extend more broadly to difficulties with self-regulation. Specifically, problems with attention, behavior and negative emotion control appear elevated in infant siblings of children with ASD. Difficulties in these areas are robustly associated with sleep. Children with sleep problems have more difficulties with attention and behavior control and exhibit more negative affect and emotional reactivity. Additional research on siblings of children with ASD is needed to elucidate their adverse developmental outcomes and the proposed studies aim to do this within the domains of self-regulation and sleep. Two studies are proposed to examine self-regulation and sleep problems and the dynamic developmental progression between them in two groups of children: infant siblings of children with ASD (high risk) and infant siblings of typically developing children (low risk). The first is a cross-sectional study examining the rates of self-regulation and sleep problems in high risk infant siblings at 24 and 36 months of age. The second is a prospective longitudinal study that assesses children at 18, 24, and 30 months of age to examine the developmental progression and associations between self-regulation and sleep. Within each study self-regulation and sleep will be assessed with behavioral, physiological, and parent-report measures. The ultimate significance of this line of research is to improve the developmental trajectories and family life of children at risk for ASD by drawing attention to often unconsidered areas of development: self-regulation and sleep. Understanding the rates of sleep problems and the roles of sleep in self-regulation has the potential to inform assessment, treatment and parenting guidelines. Dr. Schwichtenberg is an ideal candidate for the proposed studies with her educational and research experience in self-regulation and sleep development. She has specialized training in the physiological assessment of sleep and two behavioral self-regulation paradigms. Her knowledge of sleep and self- regulation includes assessment procedures, coding, screening, and analyzing and she has published in both areas. Dr. Schwichtenberg also has experience on two prospective longitudinal studies of children developing at risk, making her keenly aware of the real life considerations needed to complete such a study. With the training proposed in this application she will secure the final clinical, methodological, statistical, and lab management skills needed to transition from a postdoctoral scholar to an independent researcher with a unique line of research in the developmental processes of self-regulation and sleep in children developing at risk. Dr. Schwichtenberg's career goals are to obtain a tenure-track position in a department of Psychology or Human Development at a university with an established developmental disabilities center and to launch a research lab that studies a variety of self-regulatory capacities in young children with and at risk for developmental disabilities. Dr. Schwichtenberg's training plan will be carried out at one of the foremost centers for excellence in developmental disabilities, the University of California - Davis, M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders). Her training includes advancing her skills in clinical assessment, learning a specialized non-invasive sleep assessment technique (videosomnography), securing advanced statistical training in longitudinal data analysis, learning eye-tracking assessment and coding methods, and completing structured training in laboratory management and leadership. Her sponsors Dr. Sally Ozonoff and Dr. Thomas Anders are two internationally recognized scholars in the areas of autism and sleep and are dedicated to her training and future success.

项目摘要 这项研究的总体目标是更好地了解自我调节的发展 有自闭症谱系障碍风险的幼儿（ASD）并阐明纵向关联 在这些孩子的自我调节和睡眠之间。研究婴儿兄弟姐妹至关重要 患有ASD的孩子，因为他们不仅面临ASD的风险，而且对许多负面发展也有危险 结果包括语言困难，社会情感功能，注意力，行为和认知。 先前对有ASD风险的婴儿兄弟姐妹的研究主要集中在 沟通，社交和限制/重复的行为，但是最近的研究和初步数据表明 该小组的困难更广泛地扩展到自我调节的困难。具体来说，问题 受到关注，行为和负面情绪控制似乎在婴儿的婴儿兄弟姐妹中升高 ASD。这些领域的困难与睡眠有牢固的联系。睡眠问题的孩子有更多 注意力和行为控制方面的困难表现出更大的负面影响和情绪反应性。 需要关于ASD儿童兄弟姐妹的其他研究，以阐明其不良发展 结果和拟议的研究旨在在自我调节和睡眠领域内做到这一点。二 提出了研究以检查自我调节和睡眠问题以及动态发展 两组儿童之间的进展：ASD儿童的婴儿兄弟姐妹（高风险）和 通常患儿童的婴儿兄弟姐妹（低风险）。第一个是一项横断面研究 24岁和36个月大的高风险婴儿兄弟姐妹的自我调节和睡眠问题。这 第二是一项前瞻性纵向研究，评估18、24和30个月大的儿童 检查自我调节与睡眠之间的发育进展和关联。在每个内部 研究自我调节和睡眠将通过行为，生理和父母报告措施进行评估。 这一研究的最终意义是改善发展轨迹和家庭生活 通过注意通常未经考虑的发展领域的儿童，有ASD的风险：自我调节 和睡觉。了解睡眠问题的发生率和睡眠在自我调节中的作用 潜力为评估，治疗和育儿指南提供信息。 Schwichtenberg博士是拟议研究的理想候选人，她的教育和研究 在自我调节和睡眠发展方面的经验。她接受了生理学的专门培训 睡眠评估和两个行为自我调节范例。她对睡眠和自我的了解 法规包括评估程序，编码，筛选和分析，她已发表在 这两个领域。 Schwichtenberg博士还具有两项对儿童的前瞻性纵向研究的经验 发展危险，使她敏锐地意识到完成此类研究所需的现实生活考虑。 在本应用程序中提出的培训时，她将确保最终的临床，方法论，统计和 实验室管理技能需要从博士后学者过渡到拥有的独立研究人员 在发展的儿童自我调节和睡眠的发展过程中的独特研究线 有风险。 Schwichtenberg博士的职业目标是在 具有既定发展障碍中心的大学的心理学或人类发展 并启动一个研究实验室，该实验实验室研究各种各样的自我调节能力 发育障碍的风险。 Schwichtenberg博士的培训计划将在最重要的卓越中心之一。 加利福尼亚大学发展障碍 - 戴维斯，M.I.N.D.研究所（医学调查 神经发育障碍）。她的培训包括提高她在临床评估方面的技能，学习 专门的非侵入性睡眠评估技术（视频仪），确保高级统计 纵向数据分析，学习眼睛跟踪评估和编码方法的培训以及 完成实验室管理和领导力的结构化培训。她的赞助商Sally Ozonoff博士 托马斯·安德斯（Thomas Anders）博士是自闭症和睡眠领域的两名国际公认的学者 致力于她的培训和未来的成功。