Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT

使用远距离 3D 内窥镜 FDOCT 评估阻塞性睡眠呼吸暂停

• 批准号: 8274654
• 负责人: Jun Zhang
• 金额: $ 12.43万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-06 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8274654
• 关键词: 3-Dimensional; Accidents; Address; Affect; Algorithms; American; Anatomy; Animals; Apnea; Area; Award; Biological; Biomedical Engineering; Biomedical Research; California; Cardiovascular Diseases; Caring; Cessation of life; Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Complement; Complex; Critical Care; Data; Data Analyses; Development; Diagnosis; Diagnostic; Diagnostic tests; Dimensions; Doctor of Philosophy; Engineering; Evaluation; Fatigue; Foundations; Future; Goals; Gold; Health; Healthcare Systems; Heart failure; Hypertension; Image; In Vitro; Institutes; Internal Medicine; Investigation; Ionizing radiation; Journals; Knowledge; Laboratories; Larynx; Lasers; Lead; Lung; Maps; Medical; Medical center; Medicine; Memory; Memory impairment; Mentors; Mentorship; Methods; Modality; Motor; Motor Vehicles; Obstruction; Obstructive Sleep Apnea; Operative Surgical Procedures; Optical Coherence Tomography; Optical Methods; Optics; Oropharyngeal; Patients; Physiological; Physiology; Polysomnography; Preparation; Productivity; Public Health; Pulmonology; Research; Research Personnel; Research Training; Resolution; Resources; Respiratory physiology; Risk; Safety; Scanning; Series; Shapes; Site; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Stages; Source; Specialist; Speed; Structure; Sudden Death; Supervision; System; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Tissues; Training; Training Programs; Translational Research; Translations; United States; Universities; Visual; Width; Work; awake; base; bioimaging; career; clinical application; cohort; cost; design; editorial; experience; human subject; image processing; imaging modality; in vivo; innovation; meetings; member; minimally invasive; multithreading; optical imaging; parallel computing; phantom model; professor; programs; research study; residence; respiratory; skills; statistics; success; time interval; vehicular accident

DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States. Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for sudden death. The current gold standard diagnostic modality, overnight polysomnography is inconvenient, unable to provide information on upper airway structure and anatomy, and cannot identify the obstruction sites of upper airway in OSA patients which is important in choosing the appropriate treatment, especially surgical intervention. The long-term research goal of this project is to develop a modality to provide additional anatomic information as a valuable complimentary study to conventional sleep studies for (1) real time volumetric airway anatomy imaging during sleep and while awake; (2) physiological investigation of OSA; and (3) identification of obstruction sites that aids in choosing the most appropriate treatment for potential surgical candidates. The project proposes development and testing of an innovative high speed long range endoscopic Fourier domain optical coherence tomography (FDOCT) system capable of non-invasive real time acquisition of quantitative anatomic information such as cross sectional area and shape of upper airway for the characterization of OSA. The developed system will be tested and optimized with phantom models and ex vivo animal imaging. Then, in pilot clinical studies, FDOCT scanning will be performed in subjects with obstructive apneas, compared and correlated with standard overnight polysomnography. The proposed research training program will provide excellent experience and mentoring in the methods and conduct of biomedical and clinical research that will complement the candidate's existing expertise in engineering and optics. A team of mentors who are recognized experts and leaders in airway physiology, sleep medicine and biomedical imaging have been assembled for this K25 program. Co-mentor Dr. Zhongping Chen, professor of Beckman Laser Institute and biomedical engineering at University of California Irvine has an established track record in the development of optical imaging methods and translational research. Co-mentor Dr. Matthew Brenner, Professor and Chief of Pulmonary Medicine at the Lung Center at the University of California Irvine has experienced similar success in the study of development of new laser diagnostic technologies for translation to clinical pulmonary and critical care medicine. Co-mentor Dr. Catherine Sassoon, Chief of Division of Pulmonary & Critical Care in VA Long Beach Healthcare System and Professor of Medicine in Residence, UC Irvine, is board certified in Sleep Medicine, Pulmonary, Internal Medicine and Critical Care with over 30 years of experience in respiratory physiology. She has serves as a member of Editorial Board of American Journal of Respiratory and Critical Care Medicine and Editorial Board of Respiratory Care. Co-mentor Michael Dickel, Ph.D., Staff of Sleep Disorders Laboratory in VA Long Beach Medical Center, is a board-certified sleep medicine specialist with extensive experience in Sleep Medicine, sleep physiology, sleep research, Statistics and training Pulmonary Fellows. The opportunities of this career award will provide the candidate valuable mentorship, training, and resources to further develop his research skills and expand his knowledge and experience in the conduct of experimentation both in the laboratory and in the clinic under the close supervision, leading to advancement to independent researcher level by completion of this proposed project.

描述（由申请人提供）：阻塞性睡眠呼吸暂停 (OSA) 是影响美国 18-2000 万人的主要医疗问题。 OSA 患者患有睡眠不规律、慢性疲劳、白天嗜睡、注意力不集中和记忆力问题，其后果包括机动车事故风险增加以及心血管疾病的发生和猝死风险。目前的金标准诊断方式，夜间多导睡眠图不方便，无法提供有关上气道结构和解剖学的信息，并且无法识别 OSA 患者上气道的阻塞部位，这对于选择适当的治疗尤其是手术干预非常重要。该项目的长期研究目标是开发一种提供额外解剖信息的方式，作为传统睡眠研究的有价值的补充研究，用于（1）睡眠和清醒时的实时体积气道解剖成像； (2) OSA的生理学调查； (3) 识别阻塞部位，有助于为潜在的手术候选者选择最合适的治疗方法。该项目提议开发和测试一种创新的高速长距离内窥镜傅里叶域光学相干断层扫描（FDOCT）系统，该系统能够非侵入性地实时采集定量解剖信息，例如上气道的横截面积和形状，以表征 OSA。开发的系统将通过体模模型和离体动物成像进行测试和优化。然后，在试点临床研究中，将对患有阻塞性呼吸暂停的受试者进行 FDOCT 扫描，并与标准夜间多导睡眠图进行比较和关联。拟议的研究培训计划将在生物医学和临床研究的方法和实施方面提供出色的经验和指导，这将补充候选人在工程和光学方面的现有专业知识。该 K25 项目已组建了一支由气道生理学、睡眠医学和生物医学成像领域公认的专家和领导者组成的导师团队。共同导师陈中平博士是加州大学欧文分校贝克曼激光研究所和生物医学工程教授，在光学成像方法和转化研究的发展方面拥有良好的记录。共同导师马修·布伦纳 (Matthew Brenner) 博士是加州大学欧文分校肺科中心肺科教授兼主任，他在研究开发新型激光诊断技术以转化为临床肺科和重症监护医学方面也取得了类似的成功。联合导师 Catherine Sassoon 博士是退伍军人管理局长滩医疗保健系统肺科和重症监护科主任，也是加州大学欧文分校驻院医学教授，拥有睡眠医学、肺科、内科和重症监护领域的委员会认证，在呼吸生理学方面拥有 30 多年的经验。她担任《American Journal of Respiratory and Critical Care Medicine》和《Respiratory Care》编辑委员会成员。共同导师 Michael Dickel 博士是退伍军人管理局长滩医疗中心睡眠障碍实验室的工作人员，是一位经过委员会认证的睡眠医学专家，在睡眠医学、睡眠生理学、睡眠研究、统计学和肺研究员培训方面拥有丰富的经验。该职业奖的机会将为候选人提供宝贵的指导、培训和资源，以进一步发展他的研究技能，并扩大他在实验室和临床密切监督下进行实验的知识和经验，从而通过完成该拟议项目晋升为独立研究员水平。