Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT

使用远距离 3D 内窥镜 FDOCT 评估阻塞性睡眠呼吸暂停

• 批准号: 8499397
• 负责人: Jun Zhang
• 金额: $ 12.32万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-06 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8499397
• 关键词: 3-Dimensional; Accidents; Address; Affect; Algorithms; American; Anatomy; Animals; Apnea; Area; Award; Biological; Biomedical Engineering; Biomedical Research; California; Cardiovascular Diseases; Caring; Cessation of life; Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Complement; Complex; Critical Care; Data; Data Analyses; Development; Diagnosis; Diagnostic; Diagnostic tests; Dimensions; Doctor of Philosophy; Engineering; Evaluation; Fatigue; Foundations; Future; Goals; Gold; Health; Healthcare Systems; Heart failure; Hypertension; Image; In Vitro; Institutes; Internal Medicine; Investigation; Ionizing radiation; Journals; Knowledge; Laboratories; Larynx; Lasers; Lead; Lung; Maps; Medical; Medical center; Medicine; Memory; Memory impairment; Mentors; Mentorship; Methods; Modality; Motor; Motor Vehicles; Obstruction; Obstructive Sleep Apnea; Operative Surgical Procedures; Optical Coherence Tomography; Optical Methods; Optics; Oropharyngeal; Patients; Physiological; Physiology; Polysomnography; Preparation; Productivity; Public Health; Pulmonology; Research; Research Personnel; Research Training; Resolution; Resources; Respiratory physiology; Risk; Safety; Scanning; Series; Shapes; Site; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Stages; Source; Specialist; Speed; Structure; Sudden Death; Supervision; System; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Tissues; Training; Training Programs; Translational Research; Translations; United States; Universities; Visual; Width; Work; awake; base; bioimaging; career; clinical application; cohort; cost; design; editorial; experience; human subject; image processing; imaging modality; in vivo; innovation; meetings; member; minimally invasive; multithreading; optical imaging; parallel computing; phantom model; professor; programs; research study; residence; respiratory; skills; statistics; success; time interval; vehicular accident

DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is a major medical problem that affects 18-20 million people in the United States. Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of motor vehicle accidents and the development of cardiovascular diseases with risk for sudden death. The current gold standard diagnostic modality, overnight polysomnography is inconvenient, unable to provide information on upper airway structure and anatomy, and cannot identify the obstruction sites of upper airway in OSA patients which is important in choosing the appropriate treatment, especially surgical intervention. The long-term research goal of this project is to develop a modality to provide additional anatomic information as a valuable complimentary study to conventional sleep studies for (1) real time volumetric airway anatomy imaging during sleep and while awake; (2) physiological investigation of OSA; and (3) identification of obstruction sites that aids in choosing the most appropriate treatment for potential surgical candidates. The project proposes development and testing of an innovative high speed long range endoscopic Fourier domain optical coherence tomography (FDOCT) system capable of non-invasive real time acquisition of quantitative anatomic information such as cross sectional area and shape of upper airway for the characterization of OSA. The developed system will be tested and optimized with phantom models and ex vivo animal imaging. Then, in pilot clinical studies, FDOCT scanning will be performed in subjects with obstructive apneas, compared and correlated with standard overnight polysomnography. The proposed research training program will provide excellent experience and mentoring in the methods and conduct of biomedical and clinical research that will complement the candidate's existing expertise in engineering and optics. A team of mentors who are recognized experts and leaders in airway physiology, sleep medicine and biomedical imaging have been assembled for this K25 program. Co-mentor Dr. Zhongping Chen, professor of Beckman Laser Institute and biomedical engineering at University of California Irvine has an established track record in the development of optical imaging methods and translational research. Co-mentor Dr. Matthew Brenner, Professor and Chief of Pulmonary Medicine at the Lung Center at the University of California Irvine has experienced similar success in the study of development of new laser diagnostic technologies for translation to clinical pulmonary and critical care medicine. Co-mentor Dr. Catherine Sassoon, Chief of Division of Pulmonary & Critical Care in VA Long Beach Healthcare System and Professor of Medicine in Residence, UC Irvine, is board certified in Sleep Medicine, Pulmonary, Internal Medicine and Critical Care with over 30 years of experience in respiratory physiology. She has serves as a member of Editorial Board of American Journal of Respiratory and Critical Care Medicine and Editorial Board of Respiratory Care. Co-mentor Michael Dickel, Ph.D., Staff of Sleep Disorders Laboratory in VA Long Beach Medical Center, is a board-certified sleep medicine specialist with extensive experience in Sleep Medicine, sleep physiology, sleep research, Statistics and training Pulmonary Fellows. The opportunities of this career award will provide the candidate valuable mentorship, training, and resources to further develop his research skills and expand his knowledge and experience in the conduct of experimentation both in the laboratory and in the clinic under the close supervision, leading to advancement to independent researcher level by completion of this proposed project.

描述（由申请人提供）：阻塞性睡眠呼吸暂停（OSA）是影响美国1,8-2000万人的主要医学问题。 OSA患者患有睡眠碎片，慢性疲劳，白天嗜睡，缺乏注意力和记忆问题以及后果，包括增加汽车事故的风险以及患有突然死亡风险的心血管疾病的发展。当前的黄金标准诊断方式，隔夜多渗透学是不方便的，无法提供有关上呼吸道结构和解剖结构的信息，并且无法识别OSA患者上呼吸道上呼吸道的阻塞位点，这对于选择适当的治疗很重要，尤其是手术干预。该项目的长期研究目标是开发一种方式，以提供其他解剖信息，作为一项有价值的免费研究，用于（1）在睡眠期间和清醒时实时体积气道解剖成像（1）实时体积气道解剖成像； （2）OSA的生理研究； （3）识别有助于为潜在手术候选者选择最合适治疗方法的阻塞部位。该项目提议开发和测试创新的高速远程内镜傅立叶域光学连贯断层扫描（FDOCT）系统，该系统能够非侵入性实时获取定量解剖信息，例如横截面区域和上呼吸道的形状，以进行OSA的特性。开发的系统将通过Phantom模型和离体动物成像进行测试和优化。然后，在试验临床研究中，将在阻塞性呼吸暂停的受试者中进行FDOCT扫描，并与标准的隔夜多摄影术相比并相关。拟议的研究培训计划将在生物医学和临床研究的方法和行为方面提供良好的经验和指导，以补充候选人在工程和光学方面的现有专业知识。这项K25计划已经组装了一组知名的导师和气道生理学，睡眠医学和生物医学成像的专家和领导者。加利福尼亚大学欧文分校贝克曼激光学院和生物医学工程教授郑陈博士在开发光学成像方法和转化研究方面拥有良好的记录。加利福尼亚大学欧文分校肺中心教授兼肺中心教授兼官员Matthew Brenner博士在开发新的激光诊断技术的研究方面经历了类似的成功，以转化为临床肺和重症监护医学。 VA Long Beach Healthcare System肺和重症监护司司兼肺和重症监护署主任兼居住医学教授Catherine Sassoon博士均获得睡眠医学，肺部，内科医学和重症监护的董事会认证，具有30多年的呼吸生理经验。她曾担任美国呼吸和重症监护医学杂志编辑委员会和呼吸护理编辑委员会成员。弗吉尼亚州长滩医疗中心的睡眠障碍实验室工作人员迈克尔·迪克尔（Michael Dickel）是一位经过董事会认证的睡眠医学专家，在睡眠医学，睡眠生理学，睡眠研究，统计和培训肺部研究员方面拥有丰富的经验。该职业奖的机会将为候选人提供宝贵的指导，培训和资源，以进一步发展他的研究技能，并在近距离监督下在实验室和诊所进行实验方面的知识和经验，从而通过完成该建议的项目的完成，从而促进独立研究人员的发展。