2011 Cold Spring Harbor Conference on Neurobiology of Drosophila

描述（由申请人提供）：计划中的果蝇神经生物学会议将召集一组初级和高级科学家，讨论在非常成功的模型系统果蝇中正在进行的神经生物学研究的最新进展。该提案寻求对2011年会议的支持，这是该系列的第14次两年期国际会议。这次会议的重点是利用遗传学，分子生物学，生物化学，细胞生物学，电生理学，成像和行为分析的综合力量来解决神经生物学中的基本问题所取得的进展。所涵盖的主题将包括i）感觉系统; ii）行为，大脑功能及其演变; iii）神经疾病模型和细胞机制; iv）神经回路-发展，进化和功能; v）突触传递，发展和可塑性; vi）神经发展和进化;以及vii）技术创新和应用。经先前与会者投票决定，会议将保持中等规模（430名与会者），不举行平行会议，以便利讨论、交流想法和技术，并促进在这一迅速发展的领域开展新的合作。我们鼓励所有申请人提交摘要，大多数参与者将提交演讲或海报。发言人将由会议领导人和会议组织者从会议前几个月提交的最及时和最有趣的摘要中选出：这将确保所有会谈都涵盖最新的科学。如果会议报名过多，将选择参加者，其中至少包括每个参与实验室的一名代表。这次会议在突出年轻调查人员和妇女的工作方面有着良好的记录。为了鼓励初级研究人员的参与，一个特别的演讲是由一个写了最好的博士学位的研究生提出的。自上次会议以来。 公共卫生相关性：本次果蝇神经生物学会议的重点是利用遗传学，分子生物学，生物化学，细胞生物学，电生理学，成像和行为分析的综合力量，以解决神经生物学中的基本问题，使用模式生物果蝇的进展。整个领域的一个驱动原则是，虽然地位低下的果蝇似乎与人类没有什么共同之处，但与脊椎动物有许多相同的基因、分子和神经线路--尽管要简单得多。在果蝇遗传学一百年的研究基础上，果蝇神经生物学领域是一个新兴的领域，世界各地的许多实验室在该领域取得了重大进展。了解这些系统如何在果蝇中工作，对于我们阐明这些东西如何在高等动物中发挥作用的努力具有巨大的相关性，其后果包括我们如何看待神经疾病，大脑进化和人类研究的其他主要主题。许多研究技术，是开发用于在苍蝇有相当大的效用，在研究神经系统功能的脊椎动物和哺乳动物。会议的目的是提供一个论坛，汇集在苍蝇神经生物学领域不同领域工作的不同科学家。会议规模适中，不举行平行会议，以便利讨论、交流想法和技术，并促进在这一迅速发展的领域开展新的合作。科学组织者由先前的参与者投票选出，从而确保科学交流的新视角。我们鼓励所有申请人提交摘要，大多数参与者将提交演讲或海报。发言人将由会议领导人和会议组织者从会议前几个月提交的最及时和最有趣的摘要中选出，以确保所有会谈都涵盖最新的科学。

DESCRIPTION (provided by applicant): The planned conference on Neurobiology of Drosophila will convene a group of junior and senior scientists to discuss the latest advances in the neurobiology research that are being made in the highly successful model system the fruit fly Drosophila melanogaster. This proposal seeks support for the 2011 conference, which is the 14th biennial international meeting in this series. This meeting focuses on advances made using the combined power of genetics, molecular biology, biochemistry, cell biology, electrophysiology, imaging, and behavioral analysis to address fundamental issues in neurobiology. The topics covered will range from i) Sensory systems: ii) Behavior, brain function & its evolution; iii) Neurological disease models & cellular mechanisms; iv) Neural circuits - development, evolution and function; v) Synaptic transmission, development and plasticity; vi) Neural development & evolution; and vii) Technological innovations & applications. By vote of the previous participants, the meeting will remain of moderate size (430 participants) and will have no parallel sessions so as to facilitate discussion, exchange of ideas and techniques, and to promote new collaborations in this rapidly-evolving field. All applicants will be encouraged to submit an abstract and the majority of participants will present a talk or poster. Speakers will be chosen by session leaders and meeting organizers from the most timely and interesting abstracts submitted a few months in advance of the conference: this will ensure that late-breaking science is covered in all of the talks. In the event that the conference is oversubscribed, participants will be chosen to include at least one representative from each participating laboratory. This conference has an excellent track record for highlighting the work of younger investigators and women. To encourage participation by junior investigators, a special lecture is presented by a graduate student who has written the best Ph.D. thesis since the previous meeting. PUBLIC HEALTH RELEVANCE: This Neurobiology of Drosophila conference focuses on advances made using the combined power of genetics, molecular biology, biochemistry, cell biology, electrophysiology, imaging, and behavioral analysis to address fundamental issues in neurobiology using the model organism Drosophila melanogaster. A driving principle of the entire field is that the lowly fruit fly, while seeming to have little in common with humans, shares many of the same genes, molecules and neural wiring -albeit far simpler - with vertebrate animals. Building on one hundred years of research in fly genetics, the fly neurobiology field is a burgeoning field of endeavor with many laboratories around the world making significant advances in the field. Understanding how these systems work in Drosophila has enormous relevance to our efforts to elucidate how these things function in higher animals, with consequences including how we think about neurological disease, brain evolution and other major themes of research in humans. Many of the research techniques that are developed for use in the fly have considerable utility in research into nervous system function in vertebrates and mammals. The aim of the conference is to provide a forum to bring together a diverse group of scientists working in different areas of the field of fly neurobiology. The meeting will be of moderate size and will have no parallel sessions so as to facilitate discussion, exchange of ideas and techniques, and to promote new collaborations in this rapidly evolving field. The scientific organizers are elected by vote of the previous participants, thus ensuring a fresh perspective on the scientific exchange. All applicants are encouraged to submit an abstract and the majority of participants will present a talk or poster. Speakers will be chosen by session leaders and the meeting organizers from the most timely and interesting abstracts submitted a few months in advance of the conference, ensuring that late-breaking science is covered in all of the talks.