2011 Molecular and Cellular Biology of Lipids Gordon Research Conference

描述（由申请人提供）：本申请是对2011年戈登研究会议（GRC）脂质分子和细胞生物学的部分支持，该会议将汇集该领域的领先科学家，介绍和讨论他们的研究，并促进脂质研究的进展。该会议每隔一年举行一次，已有近50年的历史，是国内和国际公认的介绍脂质生物化学和分子生物学突破性研究的著名论坛。2011年，会议将重点关注脂质在理解健康维护和慢性疾病发展机制方面的持续出现。会议将于7月17日至22日在新罕布什尔州沃特维尔山谷的沃特维尔山谷度假村举行，将包括9个讲座和4个下午的海报会议。讲座将涵盖广泛的主题，包括脂质代谢的遗传调控，细胞脂质运输，固醇代谢的调节，磷脂代谢的功能和调节，中性脂质的细胞内储存，脂质和细胞信号，新方法和脂质前沿，以及代谢疾病的分子机制。这些会议中的32位演讲者将描述在一系列生物系统中进行的研究，从人类到酵母到模型膜，并使用多种实验方法。在脂质GRC的分子和细胞生物学的会谈，以及大型和生动的海报会议，是众所周知的，以刺激与会者谁在这种情况下将包括生物化学家，细胞生物学家，遗传学家，分子生物学家，结构生物学家和生理学家之间的动态讨论。参加这次会议的科学家从与高质量演讲者的密切互动以及演讲者和参与者的不同实验背景中获得协同效益，所有这些都是由会议的亲密气氛所促进的，会议仅限于约150名参与者。这些好处反过来又推动了该领域的未来进步和多学科合作。参与者和演讲者已经并将被选择，以反映这一医学相关科学领域的国际卓越，在年轻和经验之间取得理想的平衡。该计划包括杰出的女性和男性，以及许多不同种族的科学家。一流的设施可供残疾人使用。 公共卫生相关性：脂肪和胆固醇等脂质是生命所必需的，但过量存在时会导致心脏病发作和中风。现在还知道，脂质在其他代谢综合征疾病（包括糖尿病、肥胖症和某些类型的癌症）的发展中起重要作用。2011年戈登研究会议的分子和细胞生物学的脂质将解决当前的问题，在脂质代谢，以及如何脂质合成，分解和储存的基本过程中出错，心血管和其他疾病。

DESCRIPTION (provided by applicant): This application is for partial support of the 2011 Gordon Research Conference (GRC) on Molecular and Cellular Biology of Lipids, a meeting that will bring together leading scientists in the field to present and discuss their research and to facilitate advances in lipid research. This conference has been held every other year for almost 50 years and is nationally and internationally recognized as a prestigious forum for the presentation of ground breaking research in lipid biochemistry and molecular biology. In 2011, the conference will focus heavily on the continuing emergence of lipids in understanding the mechanisms of health maintenance and chronic disease development. The meeting will be held July 17 - 22 at the Waterville Valley Resort in Waterville Valley, New Hampshire, and will include nine lecture sessions and four afternoon poster sessions. Lecture sessions will cover a broad range of topics, including the genetic regulation of lipid metabolism, cellular lipid trafficking, regulation of sterol metabolism, function and regulation of phospholipid metabolism, intracellular storage of neutral lipids, lipids and cell signaling, novel methodologies and lipid frontiers, and the molecular mechanisms of metabolic diseases. The >32 speakers in these sessions will describe research done in an array of biological systems, from humans to yeast to model membranes, and using multiple experimental approaches. The talks at the Molecular and Cellular Biology of Lipids GRC, as well as the large and lively poster sessions, are well known to stimulate dynamic discussions among attendees who in this case will include biochemists, cell biologists, geneticists, molecular biologists, structural biologists, and physiologists. Scientists who attend this conference derive synergistic benefit from close interactions with the high quality speakers and the diverse experimental backgrounds of both the speakers and the participants, all fostered by the intimate atmosphere of the meeting, which is limited to about 150 participants. These benefits in turn drive future advances and multidisciplinary collaborations in the field. Participants and speakers have been and will be chosen to reflect international excellence in this medically-relevant area of science, with an ideal balance between youth and experience. The program includes outstanding women and men, and scientists of many different ethnicities. Superb facilities are available to accommodate handicapped individuals. PUBLIC HEALTH RELEVANCE: Lipids such as fats and cholesterol are required for life, but cause heart attacks and strokes when present in excess. It is also now known that lipids play an important role in the development of other metabolic syndrome disorders including diabetes, obesity, and some types of cancer. The 2011 Gordon Research Conference on the Molecular and Cellular Biology of Lipids will address current issues in lipid metabolism, and how the fundamental processes of lipid synthesis, breakdown, and storage go awry in cardiovascular and other diseases.