2011 Nucleic Acids Gordon Research Conference

描述（由申请人提供）：本提案要求对将于2011年6月5日至10日在缅因州比德福德的新英格兰大学举行的戈登研究会议系列中的核酸会议提供部分支持。戈登核酸研究会议成立于50多年前，从那时起，核酸生物学的基本发现影响了我们对从核酸化学到核酸在生物学几乎每个方面介导反应中所起作用等领域的理解。本次会议的广泛和长期目标是通过促进互动，将世界领先的研究人员聚集在一起，促进跨学科的讨论和合作，从而建立一个讨论新思想的重要论坛，以提高我们对核酸在生物学，人类健康和疾病中的作用的理解。这次会议的具体目标是召集35名主要专家，涵盖这一领域的关键和不同领域，共有150名与会者，在一个相对孤立的环境中举行为期五天的会议，促进与会者之间的互动。2011年的Nucleic Acids GRC会议将突出核酸研究的八个广泛分类领域的最新进展，包括DNA和RNA生物学，生物化学和生物物理学，以突出这些领域的新兴概念和技术。具体专题包括：基因组完整性; DNA复制;转录和染色质动力学;共转录和转录后调控;非编码RNA; RNA稳定性和输出;核糖体生物发生、功能和调控;核酸结构和催化。这一应用的意义在于，本次戈登研究会议将提供一个论坛，汇集和协同作用的成员，国际研究界专门从事不同领域的核酸研究。特别是，在过去十年中的发现已经导致了关于非编码核酸在细胞中的作用及其对调节核酸生物合成和加工的影响的新的兴奋。RNAi参与染色质沉默和重塑是这次会议效用的另一个主要例子，因为它汇集了看似不同的生物学领域。我们将重点鼓励年轻科学家，特别是那些新从事核酸研究的科学家，参加并出席这次会议;时间表中专门分配了从提交的摘要中选出的简短演讲。本申请的健康相关性在于，演讲和随后的讨论将有助于定义与基础科学和开发利用核酸治疗人类疾病的新策略相关的重要问题。例如，基于在Nucleic Acids GRC上提出和讨论的发现的几种核酸疗法，特别是RNAi疗法，目前正在进行黄斑变性和丙型肝炎的临床试验。 公共卫生相关性：NIGMS的既定目标是支持“为疾病诊断、治疗和预防奠定基础”的研究。在过去的50年里，戈登核酸会议一直在开会，核酸领域已经爆发了关于核酸的生物学意义和治疗潜力的巨大发现。例如，基于在Nucleic Acids GRC上提出和讨论的发现的几种核酸疗法，特别是RNAi疗法，目前正在进行黄斑变性和丙型肝炎的临床试验。我们的目标是2011年核酸GRC将继续选择演讲者和主题，这将为新思想的讨论提供一个重要的论坛，以及专门从事核酸研究的所有不同领域的研究人员之间的互动，着眼于认识治疗人类疾病的新思想。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleic Acids as part of the Gordon Research Conference series to be held June 5-10, 2011 at the University of New England, Biddeford, Maine. The Gordon Research Conference on Nucleic Acids was established more than 50 years ago and since that time, fundamental discoveries in nucleic acids biology have impacted our understanding in areas ranging from nucleic acid chemistry to the role that nucleic acids play in mediating responses in nearly every facet of biology. The broad and long-term goal of this conference is to create a critical forum for discussion of new ideas by promoting interactions by bringing together the world's leading researchers in this rapidly expanding field to foster cross-disciplinary discussions and collaborations, so as to enhance our understanding of the role nucleic acids play in biology, human health and disease. The specific aims of this meeting will be to convene 35 leading experts that cover critical and diverse areas within this field, with a total of 150 participants, for a five-day conference in a relatively isolated setting which will promote interactions among the participants. The 2011 meeting of the Nucleic Acids GRC will highlight recent advances among eight broadly classified areas of nucleic acids research that encompass DNA and RNA biology, biochemistry and biophysics with a view toward highlighting emerging concepts and technologies in these fields. Specific topics include: Genome Integrity; DNA Replication; Transcription and Chromatin Dynamics; Co- and Post-transcriptional Regulation; Non-coding RNA; RNA Stability and Export; Ribosome Biogenesis, Function and Regulation; Nucleic Acid Structure and Catalysis. The significance of this application is that this Gordon Research Conference will provide a forum for bringing together and synergizing members of the international research community specializing in diverse areas of nucleic acids research. In particular, discoveries over the past decade have resulted in renewed excitement regarding the role of non-coding nucleic acids in cells and their impact on regulating nucleic acid biosynthesis and processing. The involvement of RNAi in chromatin silencing and remodeling is another prime example of the utility of this meeting because it brings together seemingly disparate areas of biology. We will place an emphasis on encouraging young scientists, especially those newly engaged in nucleic acids research, to attend and present at this meeting; with time specifically allotted in the schedule for short talks that will be selected from submitted abstracts. The health relatedness of this application is that the presentations and ensuing discussions will help define important questions related to basic science and the development of novel strategies for utilization of nucleic acids in the treatment of human disease. For example, several nucleic acid therapeutics based on discoveries which have been presented and discussed at the Nucleic Acids GRC, specifically RNAi therapeutics, are currently in clinical trials for macular degeneration and hepatitis C. PUBLIC HEALTH RELEVANCE: The stated goal of NIGMS is to support research that "is the foundation for disease diagnosis, treatment and prevention". Over the past 50 years that the Gordon Conference on Nucleic Acids has been meeting, the field of nucleic acids has exploded with tremendous discoveries regarding the biologic significance and therapeutic potential of nucleic acids. For example, several nucleic acid therapeutics based on discoveries which have been presented and discussed at the Nucleic Acids GRC, specifically RNAi therapeutics, are currently in clinical trials for macular degeneration and hepatitis C. Our goal for the 2011 Nucleic Acids GRC is to continue to select speakers and topics that will provide a critical forum for discussion of new ideas, and interaction between investigators specializing in all the diverse areas of nucleic acids research, with an eye toward recognizing new ideas for the treatment of human disease.