Translational Neuroscience Training Grant

转化神经科学培训补助金

• 批准号: 8225365
• 负责人: Stanley Thomas Carmichael
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-04 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8225365
• 关键词: Applications Grants; Basic Science; Brain Neoplasms; Budgets; Clinical Research; Clinical Sciences; Clinical Treatment; Collaborations; Communication; Communities; Development; Disease; Education; Environment; Epilepsy; Exposure to; Faculty; Funding; Genetic; Goals; Grant; Laboratories; Mentors; Modeling; Nature; Neurologist; Neurology; Neurosciences; Neurosciences Research; Oral; Parkinson Disease; Physicians; Postdoctoral Fellow; Production; Public Health; Relative (related person); Research; Residencies; Role; Scientist; Stroke; Structure; System; Time; Training; Training Programs; Translations; United States National Institutes of Health; Writing; career development; experience; flexibility; graduate student; human disease; innovation; nerve stem cell; neurosurgery; novel; progenitor; programs; symposium; technique development; translational neuroscience

Physician-scientists occupy a critical niche in the translation of basic science findings into new clinical treatments. Within the field of neurology, physician-scientists have been at the forefront, among many examples, in developing new models of human disease, developing new clinical treatments for Parkinson's disease, epilepsy and stroke and identifying novel genetic signatures of brain tumors, glial progenitors and neural stem cells that may facilitate new therapies. However, the relative and absolute numbers of physician scientists have been declining over the past 25 years, despite the doubling of the NIH research budget during a portion of this epoch. This is in large part due to the prolonged nature of the training for a physician-scientist. The NIH has recognized this problem in the release of this RFA for Neurology and Neurosurgery Education Programs. The goal of the neurology research education program in this grant proposal is to train neurology residents in either basic or clinical science research through direct investigative study, oral/written scientific presentation, and intensive mentored career development. The structure of the training program incorporates two tiers of mentoring and focused time on oral and written presentations, with a culmination in the production of career development grant in the final year of the residency for each trainee. This training program is supported by an excellent environment for neuroscience research and education in the UCLA Neurology Department. The department has been the number 1 NIH funded neurology department since 2002, and has a large clinical and basic research faculty with diverse and well-funded programs. The residency program is relatively large (8 per year) with flexibility to place selected residents in a research program, and has a track record of training many academic neurologists in the past. The proposed education program leverages the existing research programs of the 61 mentors on this grant, and the past educational experience of the department, to develop novel basic and clinical science tutorials so as to provide technical training outside of primary research labs and to develop a larger translational neuroscience program within the neuroscience community at UCLA. This translational neuroscience program will be developed through didactics seminars, a translational neuroscience symposium and the formal investigative studies of the neurology residents on this proposed research track grant. In summary, the proposed training program in this grant develops a system of mentoring and scientific development for neurology resident trainees as well as serving as a focus for a larger environment in which to bring residents, graduate students and post-doctoral fellows into communication and collaboration around translational neuroscience training.

在将基础科学发现转化为新的临床治疗方法方面，医生科学家占据了关键的利基。在神经学领域，医生科学家一直处于最前沿，例如开发人类疾病的新模型，开发帕金森病，癫痫和中风的新临床治疗方法，并确定可能促进新疗法的脑肿瘤，神经胶质祖细胞和神经干细胞的新遗传特征。然而，在过去的25年里，医生科学家的相对和绝对数量一直在下降，尽管在这个时代的一部分时间里，NIH的研究预算翻了一番。这在很大程度上是由于长期性质的培训，为一个医生，科学家。美国国立卫生研究院在神经病学和神经外科教育计划的RFA发布中已经认识到了这个问题。本拨款提案中的神经病学研究教育计划的目标是通过直接调查研究，口头/书面科学演示和密集的指导职业发展来培训神经病学居民的基础或临床科学研究。培训方案的结构包括两个层次的指导和集中时间的口头和书面陈述，在生产的职业发展补助金在最后一年的居民为每个受训者的高潮。该培训计划得到了加州大学洛杉矶分校神经病学系神经科学研究和教育的良好环境的支持。自2002年以来，该部门一直是美国国立卫生研究院资助的神经病学部门，并拥有大型临床和基础研究学院，拥有多样化和资金充足的项目。住院医师计划相对较大（每年8名），可以灵活地将选定的住院医师安排在研究计划中，并且过去有培训许多学术神经学家的记录。拟议的教育计划利用61名导师的现有研究计划，以及该部门过去的教育经验，开发新的基础和临床科学教程，以便在主要研究实验室之外提供技术培训，并在加州大学洛杉矶分校的神经科学社区内开发更大的翻译神经科学计划。这个转化神经科学计划将通过教学研讨会，转化神经科学研讨会和神经病学居民对这个拟议的研究轨道赠款的正式调查研究来开发。总而言之，本补助金中的拟议培训计划为神经病学住院实习生开发了一个指导和科学发展系统，并作为一个更大环境的重点，使住院医生，研究生和博士后研究员围绕翻译神经科学培训进行交流和合作。