Translational Neuroscience Training Grant

在将基础科学发现转化为新的临床治疗方法的过程中，内科科学家占据着关键的位置。在神经学领域，医生科学家在开发人类疾病的新模型，开发帕金森病、癫痫和中风的新临床治疗方法，以及识别脑肿瘤、神经胶质祖细胞和神经干细胞的新遗传特征方面一直走在前列，这些都可能促进新的治疗方法。然而，在过去的25年里，尽管美国国立卫生研究院的研究预算在这一时期的一部分翻了一番，但内科科学家的相对数量和绝对数量一直在下降。这在很大程度上是由于对医生兼科学家的长期培训。美国国立卫生研究院在神经病学和神经外科教育项目RFA的发布中已经认识到这个问题。神经病学研究教育计划的目标是通过直接调查研究、口头/书面科学报告和密集指导的职业发展，培养神经病学住院医师进行基础或临床科学研究。培训计划的结构包括两层指导，重点是口头和书面陈述，并在实习的最后一年为每位学员提供职业发展补助金。该培训项目得到了加州大学洛杉矶分校神经学系神经科学研究和教育的良好环境的支持。自2002年以来，该系一直是美国国立卫生研究院资助的头号神经内科，拥有一支庞大的临床和基础研究团队，拥有多样化和资金充足的项目。住院医师项目规模相对较大（每年8人），可以灵活地将选定的住院医师安排在研究项目中，并且过去曾培训过许多学术神经科医生。拟议的教育项目利用61位导师现有的研究项目，以及该系过去的教育经验，开发新的基础和临床科学教程，以便在主要研究实验室之外提供技术培训，并在加州大学洛杉矶分校的神经科学社区内开发一个更大的转化神经科学项目。这个转化神经科学项目将通过教学研讨会、转化神经科学研讨会和神经病学住院医师的正式调查研究来发展。综上所述，本次资助的培训计划为神经内科住院医师培训生建立了一个指导和科学发展体系，并为住院医师、研究生和博士后研究人员围绕转化神经科学培训进行交流和合作提供了一个更大的环境。

Physician-scientists occupy a critical niche in the translation of basic science findings into new clinical treatments. Within the field of neurology, physician-scientists have been at the forefront, among many examples, in developing new models of human disease, developing new clinical treatments for Parkinson's disease, epilepsy and stroke and identifying novel genetic signatures of brain tumors, glial progenitors and neural stem cells that may facilitate new therapies. However, the relative and absolute numbers of physician scientists have been declining over the past 25 years, despite the doubling of the NIH research budget during a portion of this epoch. This is in large part due to the prolonged nature of the training for a physician-scientist. The NIH has recognized this problem in the release of this RFA for Neurology and Neurosurgery Education Programs. The goal of the neurology research education program in this grant proposal is to train neurology residents in either basic or clinical science research through direct investigative study, oral/written scientific presentation, and intensive mentored career development. The structure of the training program incorporates two tiers of mentoring and focused time on oral and written presentations, with a culmination in the production of career development grant in the final year of the residency for each trainee. This training program is supported by an excellent environment for neuroscience research and education in the UCLA Neurology Department. The department has been the number 1 NIH funded neurology department since 2002, and has a large clinical and basic research faculty with diverse and well-funded programs. The residency program is relatively large (8 per year) with flexibility to place selected residents in a research program, and has a track record of training many academic neurologists in the past. The proposed education program leverages the existing research programs of the 61 mentors on this grant, and the past educational experience of the department, to develop novel basic and clinical science tutorials so as to provide technical training outside of primary research labs and to develop a larger translational neuroscience program within the neuroscience community at UCLA. This translational neuroscience program will be developed through didactics seminars, a translational neuroscience symposium and the formal investigative studies of the neurology residents on this proposed research track grant. In summary, the proposed training program in this grant develops a system of mentoring and scientific development for neurology resident trainees as well as serving as a focus for a larger environment in which to bring residents, graduate students and post-doctoral fellows into communication and collaboration around translational neuroscience training.