Catechol-functionalized Coatings for Medical Devices

描述(申请人提供)：该项目旨在开发新型邻苯二酚官能化聚合物，用于提高润滑性和生物相容性的医疗器械涂层。儿茶酚已被证明是贻贝分泌的附着在水下表面的黏附蛋白的关键成分。邻苯二酚具有许多不同的非共价键相互作用，这有助于增加邻苯二酚官能化分子在有机和无机底物上的粘附性。这种能力将被用来创造与以前难以涂布的医疗器械材料(如硅胶、Pebax-72和HDPE)粘合的涂层，从而为增强这些材料的设备性能开辟道路。在第一阶段中，通过合成儿茶酚单体并与乙烯基吡咯烷酮共聚来引入儿茶酚，乙烯基吡咯烷酮是一种常用的水凝胶涂层，用于增加涂层的光滑性。虽然儿茶酚以前是附着在其他聚合物上的，但它们主要局限于聚乙二醇。该方案的创新之处在于开发了邻苯二酚功能化聚合物，用于改善医疗器械的润滑性涂层。在第二阶段，儿茶酚功能化聚合物将得到优化，应用于两种缺乏粘附性涂层的商业医疗设备(心血管放射状导入器和脑脊液分流器)，并扩大到包括血液相容、钝化和非氧化剂依赖型共聚物。 与公共健康相关：这项提案将开发用于医疗器械的涂层，以增加滑爽性和与人体的兼容性。它针对的是设备制造中使用的特定材料，这些材料很难用一种受到贻贝启发的新方法来覆盖。这些以贻贝为灵感的涂层应该可以更容易地插入医疗设备，减少组织损伤和疼痛。该提案特别针对心血管设备(放射状导入器)和神经设备(脑脊液分流术)。改进的医疗设备将改善患者的舒适度和健康。

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity and biocompatibility. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX- 72 and HDPE, opening the way to enhanced device properties for these materials. In Phase I, catechols were incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols had previously been attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. In Phase II, the catechol-functionalized polymers will be optimized, applied to two commercial medical devices (cardiovascular radial introducer and a cerebrospinal shunt) that lack adherent coatings, and expanded to include hemocompatible, passivating, and non-oxidant reliant copolymers. PUBLIC HEALTH RELEVANCE: This proposal will develop coatings for medical devices to increase slipperiness and compatibility with the body. It targets specific materials used in the device fabrication which are difficult to coat with a novel approach inspired by mussels. These mussel- inspired coatings should allow easier insertion of medical devices with less tissue injury and pain. The proposal specifically targets a cardiovascular device (radial introducer) and a neurological device (cerebrospinal shunts). Improved medical devices will improve patient comfort and health.