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Catechol-functionalized Coatings for Medical Devices

用于医疗器械的儿茶酚官能化涂料

基本信息

批准号：
8252882
负责人：
Kristin S Taton
金额：
$ 58.23万
依托单位：
INNOVATIVE SURFACE TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-15 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8252882
关键词：
Achievement Adherence Adsorption Arteries Biocompatible Blood Caliber Cardiovascular system Catechols Catheters Cell Adhesion Molecules Chemistry Coagulation Process Deposition Development Devices Docking Drug Formulations Ethylene Glycols Evaluation Fibrin Foreign Bodies Friction Future Glues Goals Government HDPE Hand Head Health Hydrogels Industry Infection Inflammation Injury Left Maleic Anhydride Manufacturer Name Medical Device Mussels Neurologic Oceans Operative Surgical Procedures Pain Patients Persons Pharmaceutical Preparations Phase Polyethylene Glycols Polymers Positioning Attribute Post-Translational Protein Processing Procedures Property Proteins Pyrrolidinones Radial Reproducibility Research Shipping Ships Shunt Device Silicone Elastomers Silicones Simulate Surface Testing Time Tissues Tyrosine Vertebral column Work adhesive protein (mussel)analog base biomaterial compatibility commercialization copolymer crosslink design ethylene glycol flexibility improved innovation interfacial monomer novel novel strategies oxidation response scale up

项目摘要

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity and biocompatibility. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX- 72 and HDPE, opening the way to enhanced device properties for these materials. In Phase I, catechols were incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols had previously been attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. In Phase II, the catechol-functionalized polymers will be optimized, applied to two commercial medical devices (cardiovascular radial introducer and a cerebrospinal shunt) that lack adherent coatings, and expanded to include hemocompatible, passivating, and non-oxidant reliant copolymers. PUBLIC HEALTH RELEVANCE: This proposal will develop coatings for medical devices to increase slipperiness and compatibility with the body. It targets specific materials used in the device fabrication which are difficult to coat with a novel approach inspired by mussels. These mussel- inspired coatings should allow easier insertion of medical devices with less tissue injury and pain. The proposal specifically targets a cardiovascular device (radial introducer) and a neurological device (cerebrospinal shunts). Improved medical devices will improve patient comfort and health.

描述（由申请人提供）：本项目旨在开发用于医疗器械涂层的新型儿茶酚官能化聚合物，具有更高的润滑性和生物相容性。儿茶酚已被证明是贻贝分泌附着在水下表面的粘附蛋白的关键成分。儿茶酚具有许多不同的非共价键相互作用，其用于增加儿茶酚官能化分子对有机和无机基底的粘附。这种能力将被用于创建涂层，粘附到以前难以涂覆的医疗器械材料，如硅胶，PEBAX- 72和HDPE，为增强这些材料的器械性能开辟了道路。在阶段I中，通过合成儿茶酚单体并与乙烯基吡咯烷酮共聚来引入儿茶酚，乙烯基吡咯烷酮是一种常用的水凝胶涂层，用于增加涂层的光滑度。虽然儿茶酚先前已连接到其他聚合物，但它们主要限于聚（乙二醇）。该提案的创新在于开发用于改善医疗器械润滑性涂层的儿茶酚官能化聚合物。在第二阶段，儿茶酚官能化聚合物将被优化，应用于两个商业医疗器械（心血管径向导引器和脑脊髓分流器），缺乏粘附涂层，并扩大到包括血液相容性，钝化和非氧化剂依赖性共聚物。公共卫生相关性：该提案将开发用于医疗器械的涂层，以增加光滑性和与人体的相容性。它针对的是设备制造中使用的特定材料，这些材料很难用贻贝启发的新方法涂覆。这些受贻贝启发的涂层应该允许更容易地插入医疗设备，减少组织损伤和疼痛。该提案专门针对心血管器械（桡动脉导引器）和神经系统器械（脑脊液分流器）。改进的医疗设备将改善患者的舒适度和健康。