Ureteral Stent Coatings

描述（由申请人提供）：该I期SBIR项目旨在开发用于输尿管支架的新型可生物降解亲水涂层。输尿管支架被广泛用于维持上尿路的引流，并有助于结石疾病的管理，以及其他输尿管梗阻（如损伤、纤维化或恶性肿瘤）的情况。然而，与心血管支架不同，输尿管支架由于结壳和生物膜形成而建议使用3个月或更短时间。超过75%的输尿管支架在这3个月的时间段内结垢，使得移除困难并引起患者疼痛。最好的商业涂层减少结垢厚度的50%和结垢的程度仅为22%的未涂层输尿管支架。该项目的重点是新型可生物降解的涂料，旨在尽量减少结壳释放剂。将评价两种不同的药物;将在四周内监测释放和体外结壳。

DESCRIPTION (provided by applicant): This Phase I SBIR project is designed to develop new biodegradable hydrophilic coatings for ureteral stents. Ureteral stents are widely used to maintain drainage of the upper urinary tract and instrumental in management of stone disease, as well as in cases of other ureteral obstruction such as injury, fibrosis or malignancies. However, unlike cardiovascular stents, ureteral stents are recommended for use 3 months or less due to encrustation and biofilm formation. Over 75% of ureteral stents are encrusted at this 3 month time period, making removal difficult and causing patients pain. The best commercial coatings reduce encrustation thickness by 50% and extent of encrustion by only 22% over uncoated ureteral stents. This project focuses on novel biodegradable coatings which release agents designed to minimize encrustation. Two different agents will be evaluated; release and in vitro encrustation will be monitored over a four week period.