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Ureteral Stent Coatings

输尿管支架涂层

基本信息

批准号：
8454859
负责人：
Kristin S Taton
金额：
$ 17.29万
依托单位：
INNOVATIVE SURFACE TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-01 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8454859
关键词：
Achievement Address Adhesives Affect Animal Testing Bacteria Binding Biocompatible Coated Materials Bladder Calcium Calcium Carbonate Calcium Oxalate Calculi Cardiovascular system Cessation of life Citric Acid Crystal Formation Crystallization Disease Drainage procedure Effectiveness Evaluation Excision Fibrosis Film Flank Pain Government Hand Head Healed Hematuria Heparin In Vitro Injury Kidney Kidney Calculi Kidney Transplantation Laceration Left Longitudinal Studies Magnesium Malignant Neoplasms Microbial Biofilms Modeling Monitor Pain Patients Persons Phase Polyurethanes Positioning Attribute Procedures Process Quality of life Reconstructive Surgical Procedures Salts Sepsis Small Business Innovation Research Grant Solutions Stents Surface Thick Time Tissues Triclosan Twin Multiple Birth Ureter Ureteral obstruction Urinary tract Urine Work antimicrobial drug biomaterial compatibility calcium phosphate combat conditioning design experience forgetting healing in vivo inhibitor/antagonist innovation novel novel strategies osteopontin prevent public health relevance scaffold urinary urologic

项目摘要

DESCRIPTION (provided by applicant): This Phase I SBIR project is designed to develop new biodegradable hydrophilic coatings for ureteral stents. Ureteral stents are widely used to maintain drainage of the upper urinary tract and instrumental in management of stone disease, as well as in cases of other ureteral obstruction such as injury, fibrosis or malignancies. However, unlike cardiovascular stents, ureteral stents are recommended for use 3 months or less due to encrustation and biofilm formation. Over 75% of ureteral stents are encrusted at this 3 month time period, making removal difficult and causing patients pain. The best commercial coatings reduce encrustation thickness by 50% and extent of encrustion by only 22% over uncoated ureteral stents. This project focuses on novel biodegradable coatings which release agents designed to minimize encrustation. Two different agents will be evaluated; release and in vitro encrustation will be monitored over a four week period.

描述（由申请人提供）：第一阶段 SBIR 项目旨在开发用于输尿管支架的新型可生物降解亲水涂层。输尿管支架广泛用于维持上尿路引流，有助于治疗结石病以及其他输尿管梗阻，例如损伤、纤维化或恶性肿瘤。然而，与心血管支架不同的是，由于结壳和生物膜形成，输尿管支架建议使用 3 个月或更短时间。超过 75% 的输尿管支架在这 3 个月内结壳，导致移除困难并给患者带来痛苦。与未涂层的输尿管支架相比，最好的商业涂层可将结垢厚度减少 50%，结垢范围仅减少 22%。该项目的重点是新型可生物降解涂料，其脱模剂旨在最大限度地减少结壳。将评估两种不同的代理人；将在四个星期内监测释放和体外结壳情况。